Hepatic stellate cell activation
Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.
... Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix ...during activation of primary mouse hepatic stellate cells in ...
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Mitochondrial uncouplers inhibit hepatic stellate cell activation
... ROS and consequent oxidative stress participate in HSC activation through several mechanisms such as glutathione depletion and activation of transcription fac- tors [23]. Indeed, the collagen type I ...
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Original Article Hepatitis B virus X protein maintains hepatic stellate cell activation by regulating peroxisome proliferator-activated receptor γ
... of hepatic fibrosis, and the activa- tion of hepatic stellate cells (HSCs) is the main mechanism of ...of hepatic fibrosis induced by HBV is not well ...the activation of HSCs and even ...
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Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... any cell contamination, we detected cell chaperone Calnexin in iPSC-EVs and in cell lysates, as reported previously ...in cell lysates but not in the EV sample, indicating that iPSC-EV samples ...
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Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster
... inhibits activation of HSCs and relieves hepatic fibrosis in vivo, triggering the endogenous regulatory mechanism to silence gremlin1 may be more in line with clinical ...HSC activation by directly ...
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Xia yu xue decoction (XYXD) reduces carbon tetrachloride (CCl4) induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF κB and TGF β1 signaling pathways
... NF-κB activation in HSC is associated with sustained liver inflammation ...NF-κB activation (P < ...MAPK activation was reduced by XYXD treatment (Fig ...
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Original Article Blockade of IGFBPrP1 attenuates canine hepatic fibrosis induced by thioacetamide via inhibition of hepatic stellate cell activation
... Rodent models with multiple advantages have revolutionized our ability to understand human diseases. However, the average rate of final translation from lab findings in rodent mo- dels to practice in clinical trials is ...
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Original Article Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion
... key cell types involved in liver repair, HSCs are hedgehog responsive [22, ...HSC activation and collagen secre- ...HSC activation; drive quiescent HSC towards the activated ...the activation ...
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miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation
... microRNAs (miRNAs), short (~22 nt) conceding RNA molecules, can directly regulate gene expression by binding to the 3 ’ UTR region of target mRNA to participate in lots of regulation of physiological process and diseases ...
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Original Article miR-144 regulates transforming growth factor-β1 iduced hepatic stellate cell activation in human fibrotic liver
... HSC activation and proliferation. Absence of TGF-β1 inhibits hepatic collagen α1 mRNA and α-smooth muscle actin (α-SMA) protein expres- sion and overexpression of TGF-β1 increases collagen α1 mRNA and α-SMA ...
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Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling
... We treated HSC-T6 cells with CsA [28], an inhibitor of CaN, and examined NFAT3 nuclear distribution levels. CsA treatment reversed NFAT3 nuclear distribution in RCAN1.4 over-expression and silencing groups separately ...
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Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
... signaling with liver fibrosis, the mechanisms by which ferulic acid attenuated TGF- β 1-induced LX-2 cell fibrosis were investigated. Our study showed that phosphorylation of Smad 2/3 was downregulated after ...
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Aster tataricus Linn., Suppresses Hepatic Stellate Cell Activation and Protects Against Thioacetamide-induced Liver Fibrosis in Rats
... It is well known that transforming growth factor- β (TGF-β)-1 is one of the main cytokines in the generation of ROS and ECM production, which can stimulate the activation and proliferation of HSC by activating its ...
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Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation
... activation is observed in vitro, as evidenced by the progressive loss of vitamin A stores, the increased prolifer- ation rate, and extracellular matrix production when cultured on plastic [2]. In the co-culture ...
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Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
... Stellate cell contractility is associated with portal hy- pertension and may lead to the collapse and shrunken state of cirrhotic livers [23]. The increased expression of contractile proteins, smooth muscle ...
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Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... TAA causes toxicity in hepatocytes and then induces acute and chronic liver injury through free radical and oxidative stress [24]. The first step of TAA metabolism is through flavin-adenin dimucleotide (FAD)-containing ...
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Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway
... Samples of liver tissue were made into buffered formalin (10%) and embedded in paraffin. The 4 uM sections were deparaffinized and hydrated by gradient ethanol, cooked in a pressure cooker for ten minutes in 25 mM citrate ...
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hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
... The cell viability was analyzed using the cell counting kit-8 (KeyGEN BioTECH, Nanjing, ...the cell viability assay, the medium was replaced with 100 μL of EV-free completed medium (DMEM medium ...
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Original Article Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation
... To further highlight the role of DMKG in the viability of HSC- T6 and BRL-3A cells, MTT assays were performed. Both cells responded significantly to DMKG tested in a dose dependent manner. Both cells exposed to lower ...
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The role of miR-29a in the regulation, function, and signaling of liver fibrosis
... 12. Bandyopadhyay, S.; Friedman, R. C.; Marquez, R. T.; Keck, K.; Kong, B.; Icardi, M. S.; Brown, K. E.; Burge, C. B.; Schmidt, W. N.; Wang, Y.; McCaffrey, A. P., Hepatitis C virus infection and hepatic ...
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