hepatic uptake
A dispersion model for the hepatic uptake and elimination of TCDD
... the uptake, distribution, and elimination of TCDD in animals have generally used the \well-stirred" or \venous-equilibrium" model to describe events occurring in the liver [6, ...of hepatic ...
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Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
... fractions is not due to contamination with albumin. These fractions are responsible for the cytoplasmic localization of bilirubin in Gunn rats, and the fractions bind bilirubin, BSP, or indocyanine green (ICG), whether ...
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Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake
... The algebraic input/output relationship approach (Ai/oRA) proves to be the most successful on the hepatic uptake mod- els derived. It can be shown that both models of the form (37) and of the form (40) are ...
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Hepatic uptake of a modified low molecular weight heparin in rats
... Because of their heterogeneous composition, it is difficult to study the pharmacokinetics of these drugs. We now report on a new method for labeling low molecular weight heparins with 131I by binding tyramine to the ...
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Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat
... in hepatic clearance was ...the hepatic clearance of both emulsions and chylomicrons revealed that the CIII (CIII-1) protein had a pronounced inhibitory effect on hepatic ...
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Hepatic organic anion uptake in the rat
... The hepatic uptake of bilirubin (BR), indocyanine green (ICG), and sulfobromophthalein (BSP) was studied in 350 anesthetized Sprague-Dawley rats by determining the initial plasma disappearance rate (V) of ...
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Hepatic oleate uptake Electrochemical driving forces in intact rat liver
... the hepatic uptake of oleate may be sodium ...acid uptake, we used microelectrodes to monitor continuously the electrical potential difference across the plasma membrane in the perfused rat liver ...
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Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent
... A lower log P value of (+)-[ 125 I]IV-OH (1.13 ± 0.01) by the introduction of the hydroxyl group compared with that of (+)-[ 125 I]pIV (2.08 ± 0.02 [23]) was expected to improve biodistribution of radioiodinated ...
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Selective uptake of intact parathyroid hormone by the liver: differences between hepatic and renal uptake
... revealed hepatic uptake of the intact hormone and addition of a smaller COOH-terminal fragment, eluting just after the intact hormone, to the hepatic venous ...
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Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene
... entero- hepatic cycle and this prolongs its biological half-life to 28 h ...cellular uptake of raloxifene and its metabolites remain to be ...in hepatic uptake of raloxifene species and to ...
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A case of multiple hepatic angiomyolipomas with high 18 F-fluorodeoxyglucose uptake
... Angiomyolipoma (AML) of the liver is a rare benign mesenchymal tumor with positive human melanoma black-45 (HMB-45) expression and a heterogeneous com- position of blood vessels, and smooth muscle cells, and adipose ...
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Amino acid metabolism during prolonged starvation
... In all subjects alanine was extracted by the splanchnic circulation to a greater extent than all other amino acids combined. Brief fasting resulted in an increased arterio-hepatic venous difference for alanine due ...
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Original Article Regulation of hepatobiliary transporters during cholestasis may mediate the phenomenon of adaptation to cholestasis induced by rifampicin in rats
... In our previous study, a mice model of the hepatic adaptation to the administration of rifampicin was developed. We observed the ini- tial elevation of cholestasis-related biochemi- cal changes and then the ...
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8-18-2014 12:00 AM In Vitro Functional Analysis Of Novel Single Nucleotide Polymorphisms In OATP1B1 And Potential Clinical Relevance
... Six non-synonymous SNPs in OATP1B1 were chosen to be analyzed in vitro. Due to lack of murine model of OATP1B1, in vitro functional studies are the best predictors of how SNPs can affect the transporter in vivo (3). ...
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Turnover and splanchnic metabolism of free fatty acids in hyperthyroid patients
... the hepatic venous catheter technique was ...splanchnic uptake of oleic acid was three times higher than in the control ...augmented uptake was a consequence of elevated arterial concentrations and ...
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Studies of peripheral thyroxine distribution in thyrotoxicosis and hypothyroidism
... the hepatic incorporation of thyroxine was augmented in subjects with Graves' disease when compared to non-Graves' disease control groups at all levels of thyroid ...of hepatic incorporation occurred in ...
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QUERCETIN IMPROVES POSTPRANDIAL HYPERGLYCEMIA IN RATS TREATED WITH HIGH-DOSE GLUCOCORTICOID
... increasing hepatic glucose production (gluconeogenesis) (3), decreasing glucose uptake into muscle and adipose tissue (4), inhibiting insulin secretion, inducing apoptotic death of pancreatic β-cells (5, ...
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Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo
... the hepatic glucose load in the regulation of liver glucose uptake has been clearly demonstrated in in vitro systems, the relationship between the hepatic glucose load and hepatic glucose ...
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A mathematical model of the human metabolic system and metabolic flexibility
... and uptake of TAG on this pathway as being both insulin-independent and insulin-dependent, however lipoprotein li- pase is not insulin stimulated in skeletal ...
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Differential Effects of Insulin on Splanchnic and Peripheral Glucose Disposal after an Intravenous Glucose Load in Man
... peripheral (extrasplanchnic) glucose uptake. Four different protocols were performed: (a) intravenous infusion of glucose alone (6.5 mg kg −1 min −1 ) for 90 min (control group); (b) glucose plus somatostatin (0.6 ...
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