Hepatitis C core protein
Hepatitis C Virus and Vaccine Development
... HCV core protein consists of the first structural protein at the amino end of the polyprotein, and performs several activities ...maturation, core protein undergoes two sequential ...
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Effect of Hepatitis C Virus Core Protein on the Molecular Profiling of Human B Lymphocytes
... HCV core also downregulates HLA class II protein expression (unpub- lished ...HCV core inhibits MHC class II mole- cules, thereby impairing antigen-pro- cessing and ...HCV core protein ...
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Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.
... HCV core protein could potentially interfere with LT b R-TRAF3 signaling pathway(s), resulting in disruption of host immune defenses, such as germinal center ...HCV core protein to LT b R may ...
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E6AP Ubiquitin Ligase Mediates Ubiquitylation and Degradation of Hepatitis C Virus Core Protein
... and C-terminal His tag, GST-C173HT fragment was amplified by PCR using pGEX GST-C173HT as a template, digested with BglII-XbaI, and subcloned into the BglII-XbaI site of ...HCV core protein in the ...
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Mitochondrial injury oxidative stress and antioxidant gene.pdf
... chronic hepatitis C virus (HCV) infection are poorly ...HCV core protein itself alters mitochondrial function and contributes to oxida- tive ...HCV core protein was expressed in ...
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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
... the core protein and virus production up to levels similar to the wild ...the core protein is rather ...the core protein and the HCV genome ...anti-core protein ...
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Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1
... core protein. On the basis of studies of the association of 14-3-3 protein with a large number of proteins, it has been suggested that 14-3-3 protein may play an organi- zational role in ...
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Characterization of Hepatitis C Virus Core Protein Multimerization and Membrane Envelopment: Revelation of a Cascade of Core-Membrane Interactions
... HCVcc core proteins are indeed envel- oped by a ...of core envelopment by differential membrane ...of core envelopment is defined as [(T ⫺ S)]/T ⫻ ...and C) JFH1 RNA-transfected Huh7 cells ...
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The effects of hepatitis C virus core protein on the expression of miR 122 in vitro
... The human hepatoma cell line Huh7.5.1 was kindly pro- vided by Scott Forrest (Scripps Research Institute, La Jolla, CA, USA) and Jin Zhong (Institute Pasteur of Shanghai, China). Huh7.5.1 cells were maintained in ...
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Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein
... HCV core derived from both ge- notype 1b and genotype ...the protein array data, we per- formed an in vitro binding assay using His-tagged core protein purified from ...with core ...
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Oligomerization of Hepatitis C Virus Core Protein Is Crucial for Interaction with the Cytoplasmic Domain of E1 Envelope Protein
... E1 protein in the mem- ...the C- terminal transmembrane domain (residues 360 to 383) are important for ER retention ...the C-terminal hydro- phobic region, the amino acid sequence of the central ...
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Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells.
... To elucidate the molecular status of superinfection with these two hepatitis viruses, we cotransfected the full-length or truncated version of HCV structural genes core and envelope 1 to[r] ...
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Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors
... proteins: core, E1, E2, p7, NS2, NS3, NS4A, NS4B, NS5A, and ...putative core protein have already been noted by a number of ...HCV core protein have been observed and im- plicated in ...
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Interaction of Hepatitis C Virus Core Protein with Viral Sense RNA and Suppression of Its Translation
... of hepatitis C virus (HCV) core protein and its viral RNA for the encapsidation, morphogenesis, and replication of HCV, the specific interaction of HCV core protein with its ...
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Assessment of total hepatitis C virus (HCV) core protein in HCV related mixed cryoglobulinemia
... Enhanced core antigenemia and a parallel increase in viremia in the presence of RTX treatment are likely the result of infectious HCV particles released from lysed B cells, as demonstrated elsewhere ...
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Hepatitis C virus core protein induces apoptosis like caspase independent cell death
... the core protein or the full length HCV polyprotein, induction of apoptosis was observed [17- ...the core protein did not exert any apoptotic effect ...expressed core protein was ...
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Self-Assembly of Nucleocapsid-Like Particles from Recombinant Hepatitis C Virus Core Protein
... the core protein and limit its conformational and/or orientational flex- ibility in the assembled NCL particle, thereby reducing size heterogeneity of the in vitro-assembled ...the core ...
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Involvement of the PA28γ-Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core Protein
... HCV core protein was amplified from HCV strain J1 (genotype 1b) and cloned into pCAG-GS (1, ...HCV core protein, which was taken to be ...
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Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis
... important protein for tumor growth, sur- vival, and cancer cell ...that hepatitis C virus (HCV) infection induces epithelial-mesenchymal transition (EMT) state and can- cer stem-like cell (CSC) ...
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Hepatitis C Virus Core Protein Blocks Interferon Signaling by Interaction with the STAT1 SH2 Domain
... mumps protein V (40). Rabies virus P protein has been re- ported to interact with STAT1 and blocks the IFN signaling pathway ...P protein has been demonstrated to inhibit the IFN signal trans- ...
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