Hepatocyte nuclear factor 4 alpha
Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation
... To evaluate whether downregulation of HNF4α by HBV would affect the tumorigenicity of hepatoma cells in vivo, we investigated the tumor formation and growth in nude mice bearing HepAD38 or HepG2-X xenograft. HepAD38 ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... transcription factor 1 (TCF1/MODY3; MIM# 142410) on chromosome 12q [5], insulin promoter fac- tor 1 (IPF1/MODY4; MIM#600733) on chromosome 13q [6], transcription factor 2 (TCF2/MODY5; MIM#189907) on ...
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Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
... Hepatocyte nuclear factors 4 alpha (HNF4a) and 3 beta (HNF3b) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of ...
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Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice
... key factor through which MSCs exert their anti-inflammatory effects ...inflammatory factor stimulation, nitrate was increased significantly in the con- ditioned ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... HNF- 4 a 2 was generated from the wild-type human HNF-4 a 2 isoform (18) cloned in the expression vector pSG5 using the Stratagene ExSite™ PCR-based site-directed mutagenesis kit according to the manufac- ...
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Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
... that affecting the uptake of nucleoside analogs. A study has reported that although the mRNA level of hENT1 in chronic lymphocytic leukemia cells is increased with the presence of interleukin 4 (IL-4), the ...
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
... Results: WGBS analyses in liver identified 969 hypermethylated and 871 hypomethylated differentially methyl‑ ated regions (DMRs) specifically identifying patients with WD, including 18 regions with genome‑wide ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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Novel variants in the hepatocyte nuclear factor 1 alpha gene in MODY and early onset NIDDM: Evidence for a mutational hotspot in exon 5
... HNF1- alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO- ...transcription factor genes with spe- cial reference to HNF1-alpha which are highly pe- ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... HNF6 inhibits HBV gene expression and replication in mice. Because HNF6 was shown to inhibit HBV replication in hepatoma cells, we further investigate the effects of HNF6 expression on HBV replication in a mouse model. ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... tumorigenesis and aging. Interestingly, hepatic deficiency of SIRT1 leads to decreased HNF-1α/FXR signaling ac- tivity, which reduces hepatic bile acid excretion and raises the chances of liver damage [28]. One of the ...
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Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
... culture, hepatocyte-like cells differentiated from iHepLPCs (iHepLPCs-Hep) at passage 30 showed a gradual increase in the expression of drug metabolism enzyme CYP3A4, albumin, α-antitrypsin (AAT), urea cycle key ...
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A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
... We would like to thank our patient and her family for participating in this study. Also, we would like to thank the following colleagues: Gérard Lambeau, Institut de Pharmacologie Moléculaire et Cellulaire, Université de ...
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Development of Simple Protocol for Generation of Functionally Active Hepatocyte-like Cells from Human Adipose Tissue-derived Stem Cells
... In this context, cell-based therapy has become the focus of intense investigation in recent years [3]. Therefore, various kinds of stem cells have been studied to examine their clinical applications in regenerative ...
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Effects of different dietary levels of AFB1 on survival rate and growth factors of Beluga (Huso huso)
... deposition, hepatocyte degeneration, nuclear pyknosis and mild necrosis.. Fat deposition, hepatocyte degeneration, focal necrosis, increase MMC.[r] ...
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The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... 5 nuclear orphan receptors with unknown ligands, apolipoprotein A1 regulatory protein (ARP-1), v-erbA-related proteins -2 and -3 (EAR-2 and EAR-3), hepatocyte nuclear factor-4 ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... FIG. 1. Structures and sequences of the HBV constructs supporting viral transcription and replication in mouse fibroblasts. (A) Structure of the HBV DNA (4.1-kbp) construct used in transient-transfection analysis. The ...
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Original Article miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2
... Hepatocellular carcinoma (HCC), which acc- ounts for about 95% of all primary liver can- cers, has become the third most frequent cause of cancer-related mortality worldwide [1, 2]. Each year, more than 700,000 patients ...
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A NOVEL MUTATION IN THE HEPATOCYTE NUCLEAR FACTOR-1 Α GENE AMONG MODY EGYPTIAN PATIENTS
... Regarding a family history, about 50% of all subjects indicated that mothers of both patients (2 and 3) with HNF1α mutations were more likely to inherit diabetes to their children than other first-degree relatives. ...
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