HER2 positive
HER2 Specific Vaccines for HER2 Positive Breast Cancer Immunotherapy
... promoted HER2-specific cellular and humoral immune responses, conferring long-lasting CTL memory which resulted in effective protection against challenge of HER2-positive D2F2/E2 breast tumor ...of ...
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New developments in the treatment of HER2-positive breast cancer
... Two HER2-specific therapies are currently approved for clinical treatment of patients with HER2-overexpressing metastatic breast ...against HER2 and is approved for first-line treatment of ...
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Original Article Correlation of HER2 codon 655 polymorphism with cardiotoxicity risk in Chinese HER2-positive breast cancer patients undergoing epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab adjuvant chemotherapy
... addition, HER2 codon 655 A>G also increas- es the dependency of cardiomyocytes on HER2 signaling as well as their sensitivity to cytotoxic drugs ...whether HER2 codon 655 A>G influences car- ...
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Molecular portraits and trastuzumab responsiveness of estrogen receptor-positive, progesterone receptor-positive, and HER2-positive breast cancer
... number, RNA-seq and reverse-phase protein array (rppa) protein expression data, we unraveled the genomic landscape and examined the HER2 expression level of HER2-positive breast cancers according to ...
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Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis
... Objective: The aim of this study was to compare the molecular profiling, including somatic mutation and somatic copy number variation (SCNV), between human epidermal growth fac- tor receptor 2 ...
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Appendicitis caused by the metastasis of HER2-positive breast cancer
... an HER2-positive primary tumor and HER2-negative meta- static tumor account for ...an HER2- negative primary tumor and HER2-positive metastatic tumor account for ...
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Role of pertuzumab in the treatment of HER2-positive breast cancer
... the HER2 receptor, represents a promising new anti-HER2 agent with a novel mechanism of action targeting the inhibition of HER2 ...broader HER2 blockade through the inhibition of HER2 ...
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A Novel Immunohistochemical Signature with the Quantification of HER2 Predicts the Complete Response in HER2-Positive Breast Cancer
... a positive or negative association exists between HER2 quantity and response grade in HER2-positive tumors (Giuliano et ...with HER2 score ...between HER2 and other known and ...
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Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer
... the HER2-positive subgroup [24, 25, ...The positive correlation of IL6 and pSTAT3 with stromal reactivation signatures in our study supports the notion that this phenomenon oc- curs in ...
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Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2 positive Breast Cancer Cells in Vitro
... the HER2 peptide and the HER2 ECD pro- tein, it is still unknown whether the aptamer would bind to the HER2-positive breast cancer ...the HER2-positive (SK-BR-3), or the ...
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Current neoadjuvant treatment options for HER2 positive breast cancer
... Abstract: Approximately one quarter of patients with breast cancer demonstrate amplification of the human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a relatively poor ...
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Role of trastuzumab in the management of HER2-positive metastatic breast cancer
... randomized; HER2+, HER2 positive; BC, breast cancer; chemo, chemotherapy; mTTP, median time to progression; OS, overall survival; q3wTrastuzumab, trastuzumab loading dose of 8 mg/kg followed by 6 ...
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Metformin increases survival in hormone receptor positive, HER2 positive breast cancer patients with diabetes
... receptor-positive, HER2-positive breast cancer by suppressing the AKT/mTOR signaling ...pathway. HER2, insulin receptor, and IGF-I receptor all act through the same downstream signaling ...
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Research Paper The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer
... from HER2-positive ...allele. HER2-I655V has also been implicated in being causative of HER2- positive BC but the evidence is inconclusive [7, 10, ...of HER2-I655V in trastuzumab ...
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Potential of afatinib in the treatment of patients with HER2-positive breast cancer
... beyond HER2 gene mutation and/or amplification. As shown for other HER2 inhibitors, primary and acquired resistance involves alterations in HER2 itself, coexpression or acquisition of bypass ...
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Role of trastuzumab emtansine in the treatment of HER2-positive breast cancer
... with trastuzumab plus docetaxel and T-DM1, respectively. In addition to an improved efficacy of T-DM1 over trastu- zumab plus chemotherapy in the first-line setting for patients with advanced HER2-positive ...
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The expanding role of pertuzumab in the treatment of HER2-positive breast cancer
... with HER2-positive breast cancer has developed with the arrival of anti-HER2 targeted therapies that have been proven to increase survival in both the metastatic and early-stage settings of the ...
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64Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients
... In 5 patients, 20 metastatic brain lesions including 7 lesions larger than 1 cm diameter and 13 lesions smaller than 1 cm diameter were previously identified by CT or magnetic res- onance imaging (MRI). In this study, ...
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Progress and challenges in HER2-positive gastroesophageal adenocarcinoma
... IV HER2-positive metastatic gastroesophageal ...untreated HER2 IHC3+ or FISH+ tumors irrespective of PD-L1 status were treated with pembrolizumab 200 mg, trastuzu- mab 6 mg/kg (after 8 mg/kg load), ...
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Targeted therapy for HER2 positive breast cancer
... Pazopanib is a selective multi-targeted receptor tyrosine kinase inhibitor of VEGF receptors 1, 2, 3, PDGF recep- tor a/β, and cytokine receptor c-kit that blocks tumor growth and inhibits angiogenesis. At ASCO 2012, a ...
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