herpes simplex viruses
Simultaneous Insertion of Two Ligands in gD for Cultivation of Oncolytic Herpes Simplex Viruses in Noncancer Cells and Retargeting to Cancer Receptors
... ABSTRACT Insertion of a single-chain variable-fragment antibody (scFv) to HER2 (human epidermal growth factor receptor 2) in gD, gH, or gB gives rise to herpes simplex viruses (HSVs) specifically ...
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Herpes simplex viruses: is a vaccine tenable?
... Based upon human epidemiologic data, the ration- ale for an HSV vaccine is fourfold. First, exogenous reinfection is exceedingly uncommon in the immune- competent host (6). Second, many more individuals are infected by ...
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Rapid serological technique for typing herpes simplex viruses
... Thirty-nine previously typed clinical isolates of HSV, as well as single isolates of VZV, CMV, adenovirus type 4, and coxsackievirus B6, were inoculated into duplicate tube cultures of 3[r] ...
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Selective assay for herpes simplex viruses expressing thymidine kinase.
... Introduction of herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA.. Transfer of thymidine kinase to thymidine kinaseless L cells by infe[r] ...
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Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir
... 48 viruses were plaque purified three times: 13 SC16 and 11 SB5 mutants were selected in the presence of increasing concen- trations of PCV, and 15 SC16 and 9 SB5 mutants were selected with increasing ...
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Genetic Relatedness of Type 1 and Type 2 Herpes Simplex Viruses
... 20015 The extent of homology between herpes simplex virus 1 and 2 HSV-1 and HSV-2 deoxyribonucleic acid DNA was measured in two ways: i by determination of the relative rate of hybridiza[r] ...
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Photodynamic Inactivation of Herpes Simplex Viruses
... HeLa cells; ii) Orthoquin was exposed to light in clear or dark tubes then used to treat a monolayer of. 334[r] ...
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Possible Role of a Cell Surface Carbohydrate in Evolution of Resistance to Viral Infections in Old World Primates
... Sindbis viruses (SINV) preferentially replicate in ␣ 1,3GT-positive cells, whereas herpes simplex viruses type 1 and type 2 (HSV-1 and HSV-2) preferentially grow in cells lacking ...different ...
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Herpes Simplex Encephalitis Occurring During Chemo-Radiotherapy in Nasopharyngeal Carcinoma – A Case Report from Saudi Arabia Khalid Riaz 1, Muhammad M Fareed 1* , Muhammad Shuja 1 Farhan Khalid 1, Mutahir Tunio1 , Rashad Akasha 1and Abdullah Al Amro1
... of herpes simplex virus has been addressed in some ...engineered herpes simplex viruses by ionizing radiation, it may provide a new strategy for destruction of therapeutically ...
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Identification of Functional Domains in Herpes Simplex Virus 2 Glycoprotein B
... Glycoprotein B (gB) is one of four membrane proteins that are essential for the entry of herpes simplex viruses (HSV) into cells, and coexpression of the same combination of proteins in transfected ...
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Incorporation of CD4 into virions by a recombinant herpes simplex virus.
... Herpes simplex viruses lacking glycoprotein D are unable to inhibit virus penetration: quantitative evidence for virus-specific cell surface receptors.. Monoclonal antibodies defining di[r] ...
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Herpes simplex virus envelopment and maturation studied by fracture label.
... The results document that herpes simplex viruses acquire at the inner nuclear membrane an envelope carrying the immature forms of the glycoproteins and that during the transit to the ext[r] ...
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Role of mannose-6-phosphate receptors in herpes simplex virus entry into cells and cell-to-cell transmission.
... (62). Herpes simplex viruses (HSVs) can infect a very broad range of cell types in vivo and in vitro, including fibroblasts, kerati- nocytes, epithelial cells, glial cells, and neurons of rodent, ...
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Enhancement of Infectivity of Murine Cytomegalovirus in Vitro by Centrifugal Inoculation
... Effect of centrifugation on titer of herpes simplex and pseudorabies viruses in cell culture fluids PFU/ml Adsorption Virus Standard Centrifugal Fold increase centrifugal/ standard Cells[r] ...
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Rapid Phenotypic Characterization Method for Herpes Simplex Virus and Varicella Zoster Virus Thymidine Kinases To Screen for Acyclovir Resistant Viral Infection
... coding herpes simplex virus-specified thymidine ...of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency ...
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Viral antibodies in cerebrospinal fluid of multiple sclerosis and control patients: comparison between radioimmunoassay and conventional techniques
... Cerebrospinal fluid antibodies to measles, rubella, vaccinia, herpes simplex, and varicella-zoster viruses in four patient study groups clinically definite multiple sclerosis [MS], early[r] ...
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Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms
... Several models for herpesvirus egress have been proposed, most suggesting that virions acquire an envelope at the inner nuclear envelope. One group of models suggest that enveloped HSV particles subsequently move from ...
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Isolation of cis-acting vaccinia virus DNA fragments promoting the expression of herpes simplex virus thymidine kinase by recombinant viruses.
... TK- cells were infected with one of these recombinant viruses and then transfected with pools of chimeric plasmids composed of a cloned herpes simplex virus thymidine kinase gene which c[r] ...
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Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS.
... Comparative neurovirulence of herpes simplex virus type 1 strains after peripheral or intracerebral inoculation of BALB/c mice.. The biology of animal viruses, 2nd ed., p.[r] ...
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Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature
... Herpes simplex encephalitis as a complication of neurosurgical procedures report of 3 cases and review of the literature CASE REPORT Open Access Herpes simplex encephalitis as a complication of neuros[.] ...
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