HFD/STZ
Zinc morin complex improves pancreatic β cell function in the HFD STZ induced experimental type 2 diabetes
... The HFD rat model with low dose of STZ has been known to induce insulin resistance and mild impairment of insulin secretion, which is similar to the clinical features of type 2 diabetes ...in HFD- ...
10
Antihyperlipidemic and Antioxidant Potential of Citrullus colocynthis fruits on HFD-Induced Hyperlipidemic and STZ-Induced Diabetic rats
... Citrullus colocynthis is claimed in traditional medical practice as cathartic and laxative and also used for diabetic conditions. A number of plant secondary metabolites including cucurbitacins, flavonoids, caffeic acid ...
6
Quercetin Attenuates Altered Colonic Contractility and Intestinal Transit In Hfd-Fed / Stz-Treated Type 2 Diabetic Rats.
... of HFD-fed / STZ-treated type 2 diabetic rats The model of type 2-like diabetes was established according to the method reported earlier (17) with ...
9
Nano scaling of Trigonelline Improves Antioxidative Status of hfd stz Induced Diabetic Mice
... In present study, healthy Swiss albino male mice (Mus Musculus) of 3-4 months age and weighing about 35-45 gm were used. Mice were kept in departmental animal house (1825/PO/EReBi/S/15/CPCSEA) under standard laboratory ...
8
Studies on the Antidyslipidemic and Anti-Inflammatory Properties of Swertiamarin, a Major Secoiridoid Glycoside of E. Littorale Leaves Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Diabetes in Rats
... study, HFD-STZ induced diabetic rats showed significantly elevated levels of FFA, cholesterol and triglycerides in plasma, liver and kidney as well as increased levels of plasma LDL-cholesterol, ...
11
TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus
... streptozotocin, HFD + STZ + sham) (DM), hypoperfused group (LFD + BCCAO) (CCH), and hypoperfused T2DM rats (HFD+STZ+BCCAO) (DM CCH) (each group n = ...while HFD consisted of 60% fat, ...
16
Characterization of Cognitive Impairment in Type 2 Diabetic Rats
... longer period. The diabetic animals did not remember the task and thus stepped down more readily from SFZ to shock zone recording a significantly lower SDL time over normal rats. The elevated plus maze served as the ...
9
Journal of Applied Pharmaceutical Science
... with HFD for 4 weeks followed by a single intraperitoneal injection of 35 mg/kg body weight ...weeks. HFD/STZ-induced diabetic rats showed a significant increase in serum glucose and fructoseamine, ...
10
PANCREATIC BETA CELL PROTECTIVE EFFECTS OF FLEMENGIA STROBILIFERA EXTRACTS IN COMBINATION MODEL OF HIGH FAT DIET AND STREPTOZOTOCIN INDUCED TYPE 2 DIABETES
... both HFD feeding and type 2 diabetes conditions produce dyslipidemia, we have evaluated the lipid profiles 31 ...in HFD+STZ control animals, due to such metabolic syndrome-like conditions, the body ...
10
ROLE OF THE INCRETINS IN HYPOGLYCEMIC EFFECT OF PHLOGACANTHUS THYRSIFLORUS NEES IN CHEMICALLY INDUCED DIABETIC MICE
... + STZ) induced diabetic ...both HFD fed obese mice and HFD + STZ induced diabetic ...in HFD fed obese mice and HFD + STZ induced diabetic mice ...in HFD fed obese ...
14
Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes
... fluorescence staining for LYVE-1 (green), CD31 (red), and DAPI (blue) of corneas demonstrated that LEC-iDKO mice displayed considerably increased lymphatic vessel growth as shown by elevated vessel density, branch ...
20
Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats
... nephropathy; STZ: Streptozotocin; HFD: High-fat diet; ADSCs: Adipose- derived mesenchymal stem cells; CKD: Chronic kidney disease; NASH: Nonalcoholic steatohepatitis; ESRD: End-stage renal disease; GvHD: ...
18
Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing
... continuous HFD feeding of C57BL/6 mice in combination with STZ ...in HFD mice than C57BL/6 (or Chow) mice after 11 weeks of HFD feeding, at which time STZ (40 mg/kg) was given to ...
13
Original Article Effects of preventative application of metformin on bile acid metabolism in high fat-fed/streptozotocin-diabetic rats
... before STZ injection, the TBA level in HFD group was significantly higher relative to that in SD group and there was a moderate reduction of the TBA level in EI group 6 week after metformin administration ...
7
Original Article Effects of oxymatrine on inhibiting hepatic endoplasmic reticulum stress signaling pathway and reducing insulin resistance in high-fat diet rats
... In HFD, there were lipid droplets in the cyto- plasm of hepatocytes, and most of the mito- chondrial cristae were fused with partial mem- brane, which was ambiguous or absent, with broken and irregularly arranged ...
11
Thesis
... Epididymal white adipose tissue (eWAT) was extracted from mice that gained weight at or above mean for the group (n = 7 in LFD FATP1 B+/+ , LFD FATP1 B-/- and HFD FATP1 B+/+ ; n = 9 in HFD FATP1 B-/- ). The ...
28
Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling
... SDM, STZ and SDZ dif- fractograms present a clear broadening and a loss of intensity of the Bragg ...milled STZ reveals that form III is mainly ...For STZ, SDM, SMZ and SDZ, this amount is X PVP ...
11
Histological study on the effect of aqueous extract of citron leaf on pancreas of hyperglycemic wistar rats
... The animals were acclimatised for four weeks and blood glucose level was monitored before induction of hyperglycaemia. Hyperglycaemia was induced in twenty overnight-fasted indiscriminately designated rats by a single ...
9
Original Article Alleviative effects of Yukmijihwang-tang on cholesterol related disease in a postmenopausal rat model and lipid accumulation in HepG2 cells
... Sham, sham-operated and not fed a high-fat HFD, high-cholesterol diet HCD; OVX-Con, OVX rats fed a high-fat HFD, high-cholesterol diet HCD; OVX-SV, OVX rats fed a high-fat HFD, high-chol[r] ...
16
IMMUNOHISTOCHEMCAL AND BIOCHEMICAL EFFECTS OF ANNONA MURICATA LINN. (ANNONACEAE) LEAF AQUEOUS EXTRACT ON PANCREATIC β-CELLS OF STREPTOZOTOCIN-TREATED DIABETIC RATS
... Healthy, male and female, Wistar rats (Rattus norvegicus) weighing 250–300 g (averaging 12 weeks old) and normal Mice (Mus domesticus) were used in this study. They were housed under standard laboratory conditions of ...
21