HIF-1α
Original Article Anti-angiogenic and anti-proliferative effects of inhibition of HIF-1α by p-HIF-1α RNAi in colorectal cancer
... human HIF-1α gene and assess its effects on HIF-1α expression and its anti-tumour functions in ...detect HIF-1α expression in HCT116 cells following transfection of ...
8
Catabolic stress induces expression of hypoxia inducible factor (HIF) 1α in articular chondrocytes: involvement of HIF 1α in the pathogenesis of osteoarthritis
... Since HIF-1 α expression is associated with low O 2 , this factor may play a role in chondrocyte survival and the maintenance of fundamental homeostasis in the normally hypoxic articular car- ...that ...
11
Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1
... In hormone-insensitive PC-3 and DU145 prostate cancer cells the mTOR inhibitor everolimus (RAD001) alone did not lead to significant cell death, however, it strongly sensitized cells to low levels (5 nM) of docetaxel. We ...
14
Original Article Hypoxia induced HIF-1α expression promotes angiogenesis, tumor budding cell survival and cell proliferation arrest in high-grade tumor budding colorectal carcinomas
... this study. The initial evaluation to classify the cases as high tumor budding versus no tumor budding was performed on H&E stained sec- tions. Single to clusters of up to 5 tumor cells were considered as a tumor ...
9
A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial- mesenchymal transition in cancer cells
... that HIF-1α expression is tightly regulated during hypoxia through a complex network of pathways governing its transcription, translation, and protein stability ...between HIF-1α and ILK that ...
15
Differential impact of various reactive oxygen species (ROS) on HIF-1α/p53 direct interaction in SK-N-MC neuroblastoma cells
... of HIF-1α and HIF-1β (also known as aryl hydrocarbon nuclear receptor transporter, ...Apparently, HIF-β is constitutively expressed independent of the level of molecular oxygen and thus, it is ...
10
Original Article In vivo and in vitro characteristic of HIF-1α and relative genes in ischemic femoral head necrosis
... of HIF-1α requires molecular oxy- gen, and the hydroxylation is inhibited by hypox- ia ...the HIF- 1α accumulates in the cytoplasm and then translocates to the nucleus, where it dimerizes with ...
7
Original Article Effect of HIF-1α, VEGF and MVD expression on angiogenesis in diabetic nephropathy
... DN HIF-1α, VEGF and MVD are significantly elevated and the HIF-1α shows positive correla- tion with VEGF and ...of HIF- 1α and VEGF, MVD to do experiment and take full advantage ...
7
Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma
... of HIF-1α was found to be significantly higher in HCC patients with increased tumor size (P < ...of HIF-1α (n = 64), low-expression of HIF-1α (n = 38), high-expression of ...
10
Original Article Expression of HIF-1α and Robo4 in the retinas of streptozotocin-induced diabetic mice
... both HIF-1α and Robo4 were on the NFL and GCL of the retinas, which was consistent with the retinal parts of the pathological changes on HE ...staining. HIF-1α and Robo4 may interact with each ...
9
HIF 2α, but not HIF 1α, promotes iron absorption in mice
... Intestine-specific deletion of Hif1a and Hif2a. (A) Immunostaining for the hypoxic marker Hypoxyprobe in WT mouse duodenum (original mag- nification, ×100) and lung (original magnification, ×200). The control cor- ...
9
Original Article Down-regulation of BAG3 inhibits proliferation and promotes apoptosis of glioblastoma multiforme through BAG3/HSP70/HIF-1α signaling pathway
... [15]. HIF-1α protects tumor cells from apoptosis by modulating Bcl2, Bax, p53, cleaved caspase 3, caspase-8, caspase-9, survivin and cytochro- me C ...and HIF-1α, and the conclusion showed a ...
14
Effects of HIF-1α on ERRα/γ protein expression in mouse skeletal muscle
... The present study protocol was approved by the Animal Care and Use Committee of Beijing Sport University. Non-transgenic mice (NT) (n=10), LT mice (n=10), and HT mice (n=10) were used to evaluate the effects of ...
7
Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF- B–HIF-1α pathway
... or HIF-1α promoter luciferase reporter with or without NF-kB ...the HIF-1α promoter ...on HIF-1α promoter ...and HIF-1α transcription ...
14
HIF 1α expression regulates the bactericidal capacity of phagocytes
... under HIF-1α control. Lysates from WT, HIF-1α–null, and vHL-null peritoneal neutrophils were analyzed by SDS-PAGE and immunoblotted with a rabbit anti-mouse CRAMP antibody against the CRAMP ...
11
Expression of hypoxia inducible factor 1α and cell cycle proteins in invasive breast cancer are estrogen receptor related
... Paraffin-embedded tumor tissue was derived from the archives of the Department of Pathology of the VU Univer- sity Medical Center. Anonymous use of redundant tumor material for research purposes is part of the standard ...
10
HIF-1 and TAZ serve as reciprocal co-activators in human breast cancer cells
... that HIF-1α physically interacts with TAZ and serves as a co-activator for TEAD/TAZ-dependent transcription, providing a novel molecular mechanism by HIF-1α stimulates transcription of the ...
11
Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression
... of HIF-1α or of β-arr1 completely inhibit angiogenic functions in endothelial cells induced by factors secreted by EOC ...β-arr1/HIF- 1α-transcriptional ...and HIF- 1α ...
15
RETRACTED ARTICLE: Long noncoding RNA ANRIL is activated by hypoxia-inducible factor-1α and promotes osteosarcoma cell invasion and suppresses cell apoptosis upon hypoxia
... 3 HIF-1α enhances ANRIL expression in osteosarcoma ...b HIF-1α mRNA levels were analyzed by real-time PCR after siRNA knockdown of ...c HIF-1α protein levels were analyzed by ...
9
Original Article LDHA is a feedback activator of hypoxia inducible factor 1-alpha in ovarian cancer
... of HIF- 1α or LDHA was conducted on an ABI Prism 7300 PCR Dete- ction System (Applied Biosys- tems, Foster City, CA, USA) wi- th SYBR Green Real-time PCR Master Mix (QPK-201, TOYO- BO, ...follows: ...
7