HIF-2
Endothelial HIF 2 mediates protection and recovery from ischemic kidney injury
... to HIF activation; e.g., chronic HIF activation in tubular epithelial cells has been shown to promote fibrosis via the induction of ECM- modifying and lysyl oxidase genes ...cologic HIF ...
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Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... of HIF-2 in the regulation of EPO expression does not appear to be restricted to ...germline-transmitted Hif-2α knockout or hypomorph alleles have suggested that renal Epo as well as retinal Epo ...
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Knockdown of a HIF-2α promoter upstream long noncoding RNA impairs colorectal cancer stem cell properties in vitro through HIF-2α downregulation
... regulating HIF-2 α ...and HIF-2 α in 23 CRC ...with HIF-2 α ...decreased HIF-2 α expression as well as impaired CSC properties, including proliferation, self- ...
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The Diagnostic Value of HIF-2 Alpha to Determine The Development and Efficacy of Treatment for Contrast Induced Nephropathy: An Experimental Study
... study, for the model group, we detected significantly increased HIF-2 α levels after. 374[r] ...
23
HIF 1 and HIF 2: working alone or together in hypoxia?
... by HIF-2α. Based on this, the authors specu- late that HIF-2α might be responsible for hypoxic induction of other genes whose functions may be involved in the promo- tion of ...of HIF-2α. Inhibition ...
5
The role of hypoxia in intestinal inflammation
... and HIF-2 α are essential in maintaining intestinal ...mucosa, HIF-1 α increases barrier protective genes, elicits protective innate immune responses, and activates an antimicrobial response through ...
5
The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Binds to HIF-1α and Causes Its Degradation via the Proteasome Pathway
... and HIF-␣ proteins is regulated by the hydroxylation of specific proline residues in the oxygen-dependent degradation domain (ODD) of HIF-␣ ...as HIF prolyl hydroxylases (HPHs), have been shown to ...
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TNFSF14/LIGHT, a Non-Canonical NF-kB Stimulus, Induces the HIF Pathway
... and HIF crosstalk, we next determined if LIGHT could induce a HIF transcriptional response in HeLa cells in normoxia (Figure ...generic HIF-dependent gene reporter assay in HeLa cells, treated with ...
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HIF pathway and c-Myc as biomarkers for response to sunitinib in metastatic clear-cell renal cell carcinoma
... was a lower proportion of tissue tumor samples in which positive expression of the biomarkers analyzed was identi- fied. These studies used different antibodies against HIF-1 α and HIF-2 α from our ...
9
Vol 71, No 2 (2019)
... by HIF-1 and/or HIF-2 transcription fac- tors, we created HIF-1α and HIF-2α gene knockdown hBM MStroC cell populations, obtained from 2 adult healthy bone-marrow donors, using ...
8
Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer
... both HIF-2 α and WISP-2 (Figure ...both HIF-2 α and WISP-2 (Figure ...of HIF-2 in WISP-2-mediated sup- pression of MCF-7 anchorage-independent growth and ...
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Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression
... One of the most extensive meta-analysis investigating 1863 patients from 10 studies reported that the PD-L1 ex- pression is correlated with poor overall survival in ccRCC and non-ccRCC. In addition, the PD-L1 expression ...
9
HIF 2α, but not HIF 1α, promotes iron absorption in mice
... and HIF-2) are central mediators of cellular adaptation to ...between HIF and the iron-regulatory hormone hepcidin, we hypothesized that HIFs, stabilized in the hypoxic intestinal epithelium, may ...
9
ZMYND8 acetylation mediates HIF dependent breast cancer progression and metastasis
... increased HIF transcriptional activ- ity in HeLa cells, as compared with EV (Supplemental Figure ...analyze HIF transcriptome profiling con- trolled by ZMYND8 in breast cancer ...parental, ...
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Expression of HIF 1α and HIF 2α correlates to biological and clinical significance in papillary thyroid carcinoma
... To our knowledge, this is the first study that demon- strates the positive correlation between HIF-1 α and HIF-2 α in PTCs. High expression of HIF-1 α and HIF-2 α was associated ...
7
Regulation of obesity and insulin resistance by hypoxia-inducible factors
... O 2 ) or hypoxia mimetic CoCl 2 treatment significantly reduced phosphorylation of insulin receptor (IR) and protein kinase B in 3T3-L1 and differentiated human ...of HIF-1 α or HIF-2 α ...
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Endogenous Erythropoietin as Part of the Cytokine Network in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
... Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its adminis- tration is protective in experimental autoimmune encephalomyelitis (EAE), an animal model of ...
7
LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118
... of HIF-1` and HIF-2` induced by hypoxia, it inhibited DMOG- and TNF`-induced HIF-1` and HIF-2` expression in ...of HIF-1β, a constitutively stable HIF subunit, an ...
12
Original Article Anti-angiogenic and anti-proliferative effects of inhibition of HIF-1α by p-HIF-1α RNAi in colorectal cancer
... of HIF- 1α and VEGF is correlated with a more advanced tumour stage and a poorer prognosis in patients with ...that HIF-1α regulates tumour angiogenesis through VEGF induction in primary and meta- static ...
8
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
... or HiF-1α ODD domain fused to luciferase and mCherry (ODD-luc) on left and right flanks, ...repeated 2 hours post ...xenografts 2 hours post De-3-oxo (100 mg/ml) or VeH ...
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