HIGH-CHOLESTEROL DIET INDUCED RAT MODEL
Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model
... HFHC diet at 4 weeks led to increased cardiac interstitial fibrosis with depleted myocardial striation, suggesting the loss of con- tractile activity of myocardium, which would eventually lead to cardiac ...
10
Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr
... hypertensive rat, SHRSP5/Dmcr, formerly called the arteriolipidosis-prone rat, is the 5th substrain of SHRSP registered at the National Bio Resource ...a model of quickly accumulating arterial fat ...
10
Antihyperlipidemic Activity of Rimonabant on High Cholesterol Diet Induced Hyperlipidemia in Rats
... standard rat chow diet. Rats on high cholesterol diet showed significant increase ...serum cholesterol, triglyceride LDL-C, VLDL-C, atherogenic index and decrease HDL-C ...tissue ...
9
Renoprotective Role of Tualang Honey against High Cholesterol Diet Induced Acute Kidney Diseases in an Animal Model
... 12% cholesterol diet induced histologically segmental mesangial hypercellularity with mesangial matrix expansion of the renal glomeruli indicating its ability to induce acute and subacute kidney ...
5
Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat
... A net retention of lipids within hepatocytes, mostly in the form of triglycerides, is a prerequisite for the devel- opment of NASH and NAFLD in patients [2]. Our results show that hepatic triglyceride contents in the ...
13
Green and black cardamom in a diet-induced rat model of metabolic syndrome
... a diet with increased simple sugars such as fructose and sucrose together with increased saturated and trans fats developed abdominal obesity, hypertension, endothelial dysfunction and cardiac fibrosis together ...
17
Effect of Berberine on promoting the excretion of cholesterol in high fat diet induced hyperlipidemic hamsters
... blood cholesterol level in hypercholesterolemic rats by inhibit- ing intestinal absorption, followed by decreasing entero- cyte cholesterol uptake and secretion ...liver, cholesterol homeostasis ...
9
Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
... Melatonin’s lipophilic properties allow it to act in cellular and subcellular compartments (Vural et al., 2001) and to maintain mitochondrial homeostasis by its effects on redox balance (Acuna Castroviejo et al., 2011). ...
178
Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
... cholesterol diet for 4 weeks caused significant changes in the blood pressure ...increase cholesterol intake are the predisposing factors of the ...poor diet control, modern life style, ...
10
Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat high fructose diet induced obesity in rat model
... More recently, the interest in the role of dietary anti- oxidants in human health has prompted research in the field of AD [19–21]. In this regard, pomegranate, consid- ered recently as functional food exhibited a ...
9
Effects of phenolic rich extracts of Clinacanthus nutans on high fat and high cholesterol diet induced insulin resistance
... Cumulative researches have reported that high caloric diets lead to an increase in adipose tissue [31]. Also, evi- dence indicates that adipocytes, as the major cellular component of white adipose tissue, ...
11
Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high cholesterol diet
... a high-speed homogeniser and ultrasonic vi- ...through high-pressure liquid chromatography (HPLC) by using the Shodex sugar KS series containing KS-G, KS-804, and KS- 805 columns and detected using a RI ...
11
Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease: SPONTANEOUS AND HIGH CHOLESTEROL DIET INDUCED ARTERIOSCLEROSIS
... In a subsequent study, 3-mo-old pigs (11 controls and 7 with homozygous vWd) were placed on a 2% cholesterol diet for up to 6 mo. All of the controls developed arteriosclerotic plaques in the aorta, and in ...
10
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
... intestinal cholesterol transporter expression Based on the finding that CREBH overexpression prevents LD-induced hypercholesterolemia and cholelithiasis, we performed real time-PCR to identify possible ...
12
Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet
... normal cholesterol metab- olism and contains numerous proteins and enzymes related to cholesterol ...in cholesterol synthesis; the low-density lipoprotein receptor (LDLR), which is responsible for ...
10
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation
... standard diet or HFD with or without ABA in the drinking water for 12 ...HFD induced insulin resistance peripherally and increased the levels of proinflammatory markers in in the ...control diet fed ...
11
Antioxidant Compounds of Gayam Seed (Inocarpus Fagiferus Fosb) to Prevent Atherosclerosis in Wistar Rat with High Cholesterol Diet
... total cholesterol, triglyceride, and LDL cholesterol, except the HDL cholesterol in blood plasm of Wistar rat so it are potential to prevent atherosclerosis disease (Sukadana et ...
7
Testosterone deficiency and dietary therapeutic interventions in the rat model of diet-induced metabolic syndrome
... <0.1 % of dry algae) and lowered total body fat mass by 24% which may be attributed to the inhibition of intestinal absorption of fatty acids. In addition higher magnesium content of UO (4.1% vs 1.3% of dry algae) ...
7
Testosterone deficiency and dietary therapeutic interventions in the rat model of diet-induced metabolic syndrome
... 182 Abstract Inulin and oligofructose, well known for their prebiotic effects to attenuate weight gain and promote weight loss via inhibiting energy intake, have been suggested for obesity management. The present study ...
238
BARIATRIC SURGERY AND ITS EFFECT ON THE METABOLIC ASPECT IN DIET INDUCED OBES RAT MODEL
... ABSTRACT Bariatric surgery is the only treatment for obesity after failure of medication that may confers the definitive weight loss at long-term duration. Furthermore to weight loss there is a strong evidence to cure ...
14