High glucose (HG)
High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity
... the HG-induced phosphatase directly dephosphorylates p53Ser46 or rather it targets the up- stream kinases claimed to phosphorylate p53 at Ser46, such as homeodomain-interacting protein kinase 2 (HIPK2) [9], ATM ...
10
<p>Alpha-Mangostin Improves Cardiac Hypertrophy and Fibrosis and Associated Biochemical Parameters in High-Fat/High-Glucose Diet and Low-Dose Streptozotocin Injection-Induced Type 2 Diabetic Rats</p>
... The High-fat (HF) diet (TestDiet, 58V8 rat chow, Richmond, USA) containing ...20% high-glucose (HG) drinking water was orally fed to animals for 3 weeks to induce type 2 diabetes ...blood ...
12
Oxidative Stress Activated NHE1 Is Involved in High Glucose Induced Apoptosis in Renal Tubular Epithelial Cells
... 1. High glucose (HG) induced apoptosis and oxidative stress in HK-2 ...mM glucose (HG) at 48 ...in HG-stimulated cells was monitored by DCFH-DA and relative ROS was ...
8
Original Article The role of IQGAP1 in high glucose-induced apoptosis of podocytes and its possible mechanisms
... of high glucose ...with glucose with normal concentration as control, mannitol, HG, HG with benazepril and HG with u0126, ...vitro, HG suppressed the expression of IQGAP1, ...
8
High glucose induces human endothelial dysfunction through an Axl-dependent mechanism
... low glucose (LG) and increased cell migration in the presence of high glucose (HG) ...altered glucose tolerance, inflammation, and endothelial ...
13
Original Article Interleukin-33 prevents high glucose-induced apoptosis in H9c2 cardiac cells by inhibiting reaction oxygen species- activated JNK and p38 MAPK pathway
... against high glucose (HG)- induced apoptosis in H9c2 cardiac cells and explore the potential ...to HG with or without IL-33 ...to HG resulted in a loss in cell viability and an increase ...
8
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
... a high-glucose ...of high glucose-activated HSCs through the JNK signaling ...of high glucose-activated HSCs through blocking the ERK signaling ...
7
Zuogui Wan rescues the high glucose induced damaging effects on early embryo development
... the glucose metabolism ...in high-glucose medium by reducing ROS and modulating the metabolic profile, we included vehicle or ZGW with various concentration and measured develop- mental rates, ROS ...
7
Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1
... tent high glucose lead to increasing of double-membrane vacuoles, which was a typical of autophagosomes ...intermittent high glucose lead to a significant increase in conservation of LC3-II ...
8
MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1
... that high glucose meant higher MMP-2 and MMP-9 expressions in the supernatants of CFs than in those of normal glucose ...after high glucose treatment, while the miR-495 mimic blocked ...
13
Mesenchymal stem cells protect podocytes from apoptosis induced by high glucose via secretion of epithelial growth factor
... by HG, we found the process of apoptosis was inhibited by MSCs-CM, and the decrease and the disorder of po- docytic synaptopodin and nephrin were ameliorated by ...
11
<p>Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin-linked kinase</p>
... Olfactory mucosa lamina propria was used in 7-day-old rat ’ s pups for isolation high proliferation cells. A mixture of ketamine/xylazine (60/6 mg/kg) was used for anesthe- sia. Then, the lower jaw and hard palate ...
20
Original Article Inhibition of lncRNA Dlx6os1 decreases cell proliferation and fibrosis and increases cell apoptosis in diabetic nephropathy
... under high glucose (HG) ...mmol/L glucose (HG group), 5.6 mmol/L glucose (normal glucose group, NG group) and ...mmol/L glucose plus 24.4 mmol/L ...
8
Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte
... in high glucose-induced MPC5 cells and DN ...that HG induced the activation of mTOR/p62 signaling pathway and cleaved caspase3 expression; the inhibition of Beclin1 and LC3II/I were enlarged when ...
15
Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum
... in vitro research showed that acute exposure of isolated arteries to high glucose (HG) or MGO affects endothe- lium-dependent relaxations in different vascular beds [1, 3, 13–15]. Oxidative stress ...
12
induced fibronectin production in rat mesangial cells
... by high glucose or transforming growth factor-β 1 (TGF-β 1 ), and investigated the possible ...mechanisms. High glucose (HG) or TGF-β 1 significantly increased collagen-1 and ...
10
Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability
... of high and prolonged cellular oxidative stress (Ox-S) ...blood glucose as assessed by glycaemic variability (GV), a phenomenon that occurs daily in diabetic subjects, can induce func- tional and structural ...
14
Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model
... Obesity and diabetes are increasing at alarming rates throughout the world leading to an increase in co- morbidities [1]. Dyslipidemia and insulin resistance pre- dispose to type 2 diabetes and metabolic syndrome [2–4]. ...
14
Relating Fish Hg to Variations in Sediment Hg, Climate and Atmospheric Deposition
... in-lake Hg accumulations due to variations in weather, season, atmospheric Hg deposition, surrounding vegetation, and geological Hg exposure ...atmospheric Hg deposition, Sediment THg and Fish ...
18
<p>Polymer-Assisted In Situ Synthesis of Silver Nanoparticles with Epigallocatechin Gallate (EGCG) Impregnated Wound Patch Potentiate Controlled Inflammatory Responses for Brisk Wound Healing</p>
... Further, HG-EGCG showed only 6% lag in wound closure percentage on day 15 compared to the commercial fi lm dressing NeuSkin-F ® ...area, HG-Ag-EGCG presented complete wound closure and higher resemblance ...
18