High mobility group box protein 1
High Mobility Group Box Protein-1 Correlates with Renal Function in Chronic Kidney Disease (CKD)
... (CVD). High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nuclear and cytosolic protein known as a transcription and growth factor, recently identified as a ...
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High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
... High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and ...
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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks in- side and outside of ...
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<p>Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis</p>
... High mobility group box protein 1 (HMGB1) is a nonhistone nuclear protein that has a dual ...function. 1 Inside the cell, HMGB1 binds DNA, regulating transcription ...
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High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
... count is correlated with the increase of HMGB-1 in bac- terial pneumonia patients co-infected with influenza [33]. In our study, we have also determined a correlation between an increase in HMGB-1 levels ...
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
... and protein levels of HMGB1 as compared to healthy ...MS group, differences were driven by patients with relapse-onset MS, particularly by patients with ...and protein levels for HMGB1 were clearly ...
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High mobility group box protein 1 in complex with lipopolysaccharide or IL 1 promotes an increased inflammatory phenotype in synovial fibroblasts
... be mediated by simultaneous engagement of an HMGB1 receptor (RAGE or TLR4) and the partner ligand recep- tor. By blocking IL-1RI and TLR4 with the respective receptor antagonists (IL-1 receptor antagonist or ...
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High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis
... High mobility group box protein 1 (HMGB1) is a highly conserved protein, ubiquitously expressed in the nucleus of all vertebrate ...this protein have been well ...
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Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear DNA-binding protein, proved recently to be a potent proinflammatory cytokine implicated as an important ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... literature. Protein NMR spectroscopy is a powerful biophysical technique that can be used to obtain physical, chemical and electronic information about proteins in ...interaction. Protein NMR has been ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... served protein containing two DNA- binding domains (HMGB A and B) and a natively charged C tail (for transcription stimulation) domain (Figure ...B box has been identified as a function domain, which can be ...
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Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
... Several recently studies have tried to identify sensitive diagnostic markers reflecting the severity of AA, such as bilirubin and procalcitonin levels. In a prospective study, Procalcitonin, an established marker of ...
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Bench to bedside review: High mobility group box 1 and critical illness
... targeting high-mobility group box 1 As yet, of course, no anti-HMGB1 therapeutic is available for clinical administration to ...
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Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria
... Figure 1 HMGB1 is released with Plasmodium falciparum infection and predictive of malarial disease severity and clinical outcome in Ugandan children. Plasma HMGB1 levels at clinical presentation are significantly ...
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Inflammasomes: Pandora’s box for sepsis
... of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to endothelial cells and stimulating the induction of higher ...
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The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear deoxyribonucleic acid (DNA)-bind- ing protein, was recently rediscovered as a new potent pro-inflammatory ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... rocytosis (37). RAGE-deficient macro- phages were shown to have a dimin- ished capacity to phagocytose, and the inhibitory effect of HMGB1 on phagocy- tosis was contributed to the C-terminal tail of the protein. ...
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Molecular isoforms of high mobility group box 1 are mechanistic biomarkers for epilepsy
... μl protein G–Sepharose beads for 1 hour at ...for 1 hour, followed by alkylation of newly exposed thiol groups with 90 mM NEM at 4°C for 10 ...whole protein molecular weights, acetylated ...
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High mobility group box-1 and its clinical value in breast cancer
... HMGB1 protein in tissues, tumor samples and corresponding adjacent normal tissues were collected from the 56 cancer patients undergoing modified radical mastectomy or breast conservation surgery, and tissue ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... in protein loading buffer with 4% SDS, boiled for 5 min and resolved by 2–12% gradient SDS-PAGE and transferred to a nitrocellulose membrane for subsequent probing with monoclonal antibodies against HMGB1 and ...
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