high mobility protein 1
Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... literature. Protein NMR spectroscopy is a powerful biophysical technique that can be used to obtain physical, chemical and electronic information about proteins in ...interaction. Protein NMR has been ...
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Potential Role for a β-Catenin Coactivator (High-Mobility Group AT–Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1
... FIG 7 ORF2 stimulates coactivator enhancement of  -catenin-dependent transcription. (A) Neuro-2A cells were cotransfected with 0.1 g of the Top-Flash luciferase reporter and 0.25 g of  -catenin (S33Y). Where ...
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High Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater
... of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be ...
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Inflammasomes: Pandora’s box for sepsis
... of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to endothelial cells and stimulating the induction of higher expression of ...
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The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear deoxyribonucleic acid (DNA)-bind- ing protein, was recently rediscovered as a new potent pro-inflammatory cytokine when ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... HMGB1 can be released from the cell into the extracellular space, where it acts as a damage-associated molecular pat- tern (DAMP) or alarmin. Translocation from the nucleus to the cytoplasm oc- curs through acetylation ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... found with non-PARylated HMGB1. To determine if the increased binding of PARylated HMGB1 to apoptotic thymo- cytes is due to interaction with PS, PARylated HMGB1 was added to viable thymocytes, which do not have PS ex- ...
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High mobility group box protein 1 in complex with lipopolysaccharide or IL 1 promotes an increased inflammatory phenotype in synovial fibroblasts
... extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and ...
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High Mobility Group Box Protein-1 Correlates with Renal Function in Chronic Kidney Disease (CKD)
... All CKD patients in our study had ele- vated circulating HMGB-1 levels as com- pared with controls. The relationship be- tween immunodetectable levels of the cytokine in serum and bioactivity in tis- sue is not ...
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Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
... all cases. The emergencies are sometimes misdiagnosed or missed. Although the surgery appendectomy itself is a relatively safe surgical procedure, rates of negative ap- pendectomy and perforated appendicitis remain ...
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A comparison of high mobility group box 1 protein, lipopolysaccharide binding protein and procalcitonin in severe community acquired infections and bacteraemia: a prospective study
... HMGB1 has been known for many years as a chromosomal protein. In recent years there has been interest in HMGB1's role as a proinflammatory cytokine [4,5]. Animal models have shown that HMGB1 has an important role ...
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Roth, Stefan (2018): Alarmin-induced atherosclerosis progression after stroke. Dissertation, LMU München: Medizinische Fakultät
... Acute brain lesions induce multiphasic alterations of the peripheral immune response comprising early activation and subsequent immunosuppression. In this project, we focused on soluble pro- inflammatory ...
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Emerging roles for HMGB1 protein in immunity, inflammation, and cancer
... Abstract: High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein ...with high acidic and basic amino acid content, it was ...
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HMGB1: Endogenous Danger Signaling
... nuclear protein, High mobility group box-1 (HMGB1), has received par- ticular attention as fulfilling the functions of an alarmin by being involved in both infectious and non-infectious ...
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
... High mobility group box protein 1 (HMGB1) is a DNA- binding non-histone protein that acts as a transcriptional regulator and nucleosomal stabilizer ...
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Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear DNA-binding protein, proved recently to be a potent proinflammatory cytokine implicated as an important mediator of ...
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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... and neuronal cells (26). With regards to neuronal activity, it has been shown that HMGB1 increases the excitability of pri- mary afferent neurons (37,38), potenti- ates NMDA-induced hippocampal neu- ronal activity ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... HMGB1 has been known from many years as chromo- somal protein, but in recent years it has been very intensively investigated as a proinflammatory cytokine [9,23]. In 1999, Wang et al [24] found increased levels of ...
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High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis
... Our study showed that the serum levels of HMGB1 in patients with mild and severe acute cholecystitis is significantly higher than in normal group. This data suggests HMGB1 may play a critical role in the pathogenesis of ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... ASD. In 2010, Emanuele et al. (58) firstly suggested that HMGB1 can play a role in ASD. They observed higher HMGB1 blood concentrations in a sample of young adults with ASD than in healthy age- and gender- matched ...
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