High molecular weight kininogen
Association of factor XI and high molecular weight kininogen in human plasma
... and high molecular weight kininogen were found associated in normal human plasma at mol wt 380,000 as assessed by gel filtration on Sephadex ...The molecular weight of Factor XI ...
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High molecular weight kininogen binds to unstimulated platelets
... Studies were performed to determine if the unstimulated platelet membrane has a site for high molecular weight kininogen (HMWK) binding. 125I-HMWK bound to unstimulated platelets. Zn++ was ...
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Prekallikrein deficiency in a kindred with kininogen deficiency and Fitzgerald trait clotting defect Evidence that high molecular weight kininogen and prekallikrein exist as a complex in normal human plasma
... of high molecular weight kininogen that may stabilize the prekallikrein in ...and high molecular weight kininogen apparently exist as a complex in normal plasma, ...
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High molecular weight kininogen is an inhibitor of platelet calpain
... a high concentration of platelet-derived calcium-activated cysteine protease (calpain) can cleave high molecular weight kininogen ...total kininogen. Reconstitution of total ...
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High molecular weight kininogen A secreted platelet protein
... contain high- molecular weight ...total kininogen antisera (antisera that recognizes both high- and low-molecular weight kininogen) extracts of platelets contained ...
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The Binding and Cleavage Characteristics of Human Hageman Factor during Contact Activation: A COMPARISON OF NORMAL PLASMA WITH PLASMAS DEFICIENT IN FACTOR XI, PREKALLIKREIN, OR HIGH MOLECULAR WEIGHT KININOGEN
... The ability of human Hageman factor (coagulation factor XII) to bind to a glass surface and its susceptibility to limited proteolytic cleavage during the contact activation of plasma have been studied using normal human ...
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Platelet Glycoprotein Ib: A Zinc-Dependent Binding Protein for the Heavy Chain of High-Molecular-Weight Kininogen
... (1996) Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and Factor. XII: Identity with the receptor that binds to the[r] ...
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The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin
... We are interested in how schistosomes modify their environment to promote their survival, and we are in- vestigating the molecular capabilities of selected proteins expressed at the worm surface [7–10]. Here, we ...
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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor
... respectively. High molecular weight kininogen (HK) also stimulates the expression of cell surface plasminogen activator activity through its ability to serve as an acquired receptor for ...
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Inactivation of Factor XIa by Plasma Protease Inhibitors: PREDOMINANT ROLE OF α1 PROTEASE INHIBITOR AND PROTECTIVE EFFECT OF HIGH MOLECULAR WEIGHT KININOGEN
... Since both Factor XI and prekallikrein are activated by the same enzyme Factor XIIa in the presence of the same cofactor HMW kininogen, it is clear that both the differential effect of p[r] ...
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Activation and function of human Hageman factor The role of high molecular weight kininogen and prekallikrein
... both high molecular weight (HMW) kininogen and ...HMW kininogen does not affect the binding of Hageman factor to surfaces, but it enhances the function of surface-bound Hageman factor ...
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Purification of High Molecular Weight Kininogen and the Role of This Agent in Blood Coagulation
... with high molecular weight (HMW) kininogen deficiency established the importance of this plasma protein for in vitro initiation of blood ...its weight as bradykinin upon incubation with ...
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Flaujeac factor deficiency Reconstitution with highly purified bovine high molecular weight kininogen and delineation of a new permeability enhancing peptide released by plasma kallikrein from bovine high molecular weight kininogen
... Flaujeac trait is the functional deficiency of a plasma protein of the intrinsic coagulation, kinin-forming, and plasma fibrinolytic pathways. The Flaujeac factor in man has been isolated and tentatively identified as a ...
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Potentiation of the function of Hageman factor fragments by high molecular weight kininogen
... HMW kininogen exerted its effect even in the absence of prekallikrein since the hydrolysis of acetylglycyl-lysine methyl ester by HFf was increased by HMW ...HMW kininogen is to augment the catalytic action ...
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Function and Immunochemistry of Prekallikrein High Molecular Weight Kininogen Complex in Plasma
... HMW kininogen-deficient plasma was increased in a dose- dependent manner by the addition of HMW kininogen, reaching 85% of normal level at a concentration of ...HMW kininogen-deficient plasma was ...
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Human neutrophils contain and bind high molecular weight kininogen
... neutrophils was dependent upon Zn2+. Binding of 125I-HMWK to neutrophils was specific and 90% reversible. 125I-HMWK binding to neutrophils was saturable with an apparent Kd of 9-18 nM and 40,000-70,000 sites per cell. ...
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Cleavage of human high molecular weight kininogen markedly enhances its coagulant activity Evidence that this molecule exists as a procofactor
... associated with the kaolin pellet. In normal plasma, the adsorption of HMW-kininogen to kaolin increased as the quantity of kaolin was increased in the incubation mixture. However, the HMW-kininogen in ...
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Influx of kininogens into nasal secretions after antigen challenge of allergic individuals
... secretions. Allergic individuals (n = 6) and nonallergic controls (n = 5) were challenged with antigen; and by using specific radioimmunoassays, nasal washes, obtained before and after challenge, were assayed for ...
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Surface mediated defense reactions The plasma contact activation system
... Four proteins, namely Factor XII XII,' Hageman factor, prekallikrein PK, Fletcher factor, high molecular weight kininogen HMWK, Williams, Fitzgerald, Flaujeac factor, and Factor XI, XI, [r] ...
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High molecular weight glutenin subunits and the classification used in Brazilian wheat industry.
... and high molar mass (HMM) glutenins (Comino et ...low molecular weight (LMW) and high molecular weight (HMW), respectively (Lukow et ...
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