High-Risk Neuroblastoma
Nano targeted induction of dual ferroptotic mechanisms eradicates high risk neuroblastoma
... various high-risk neuroblastoma cell lines after exposure to WA, etoposide (Eto), and cisplatin ...a high dose (10 μM) and a medium dose (1 μM) of ...a high dose (10 μM) and a medium ...
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Distinct signatures of the immune responses in low risk versus high risk neuroblastoma
... filtered data set was used to compare the LR-patients with HR-patients. The analysis identified 408 genes dif- ferentially expressed between the two groups (global permutation p value = 0.01). Among them, 91 were up ...
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Incorporation of high-dose 131I-metaiodobenzylguanidine treatment into tandem high-dose chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma: results of the SMC NB-2009 study
... of high-risk neuroblastoma has im- proved after the introduction of high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto- SCT), the outcome was still unsatisfactory ...of ...
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Accumulation of potential driver genes with genomic alterations predicts survival of high-risk neuroblastoma patients
... 145 neuroblastoma patients to detect potential driver ...defined high-risk patients, we identify 193 recurrent regions of copy number alterations (CNAs), resulting in 274 altered genes whose ...
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Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
... Neuroblastoma is a tumor derived from primitive cells of the sympathetic nervous system that, despite advances in its treatment still has a poor survival for high-risk patients [1]. Risk ...
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Combined Treatment Strategy and Outcome of High Risk Neuroblastoma: Experience of the Children’s Cancer Hospital Egypt
... Background: Neuroblastoma (NB) is remarkable for its wide spectrum of clinical behavior and biological characteris- tics in relation to ...diagnosed high risk NB patients were prospectively enrolled ...
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Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma
... The amplified cDNA, as purified by column chromatography, was converted into aminomodified oligonucleotides purified by column chromatography and alcohol precipitation and then labelled with fluorescent tracers Cy3 or ...
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Spotlight on dinutuximab in the treatment of high-risk neuroblastoma: development and place in therapy
... Abstract: Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system which accounts for 8% of childhood ...express high levels of the disialoganglioside ...treating high-risk ...
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The Impact of Pretransplant Disease Characteristics on the Outcome of Autologous Stem Cell Transplantation for Neuroblastoma with High Risk Features: A Retrospective Model from a Limited Resources Country
... DOI: 10.4236/jct.2019.106035 424 Journal of Cancer Therapy 2015. Three hundred thirty-one patients (61.2%) were labeled as high-risk neuroblastoma. Autologous stem cell transplantation was performed ...
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Neuroblastoma in Saudi Children: A Single Center Experience (2006 2014)
... for high-risk Neuroblastoma remains rather disappointing, with less than 50% of children with stage 4 NBL being alive after 5 years, despite intensive multimodality ...for high-risk NBL ...
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RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes
... for high-risk neuroblastoma patients remains poor, with only 40–50% 5-Year overall survival (OS) and <10% long-term ...aggressive neuroblastoma, and identified its influence in better ...
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The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy
... with neuroblastoma is highly variable, ranging from spontaneous regression to wide- spread metastatic ...aggressive neuroblastoma remains dismal. The clinical heterogeneity of neuroblastoma mirrors ...
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Infection of peripheral blood mononuclear cells and cell lines by cell free human T cell lymphoma/leukemia virus type I
... The two glioma cell lines bound high levels of the virus and were susceptible to infection by HTLV-I, while the neuroblastoma cell line, SK-N-MC, although binding high levels of the viru[r] ...
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
... understanding neuroblastoma genetics at a genomic ...identified high copy somatic ALK amplifications in a subset of neuroblastoma tumors, and subsequent resequencing demonstrated that point mutations ...
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Polymorphisms in <em>MYCN</em> gene and neuroblastoma risk in Chinese children: a 3-center case–control study
... with neuroblastoma risk (GA vs GG: adjusted odds ratio ...develop neuroblastoma in the following subgroups: children older than 18 months, tumor derived from the adrenal gland, and clinical stages ...
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Levels of anxiety in high risk pregnant women
... Objective: To identify the levels of anxiety in high-risk pregnant women. Methods: Cross- sectional study of quantitative-descriptive approach conducted with 112 pregnant women admitted to Agamenon ...
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Expression of Chemokine Receptor CXCR4 in Primary and Metastatic Neuroblastoma Expression of CXCR4 in Neuroblastoma
... of neuroblastoma. A total of 31 archived tissue specimens of neuroblastoma were subjected to immunohistochemical staining using a monoclonal antibody specific for ...metastatic neuroblastoma. There ...
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Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma
... Flow cytometry. To analyze the frequency of human leukocytes and their subsets as well as the frequency of human neuroblastoma cells in the BM of NoD/SCID mice (see In vivo experiments), we used 4 sets of ...
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NEUROBLASTOMA SYMPATHETICUM
... In tllose cases wherein there are no de- monstrable metastases, the treatment of choice consists of total excision, followed. l)y local x-ray irradiation; this has resulted[r] ...
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NEUROBLASTOMA IN CHILDHOOD
... The patient was a well-developed, well- imourished child in no acute distress. A large, hard mass extended 4 fingerbreadths below the left costal margin and the liver edge was palpa- bie[r] ...
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