Hippo Pathway
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
... ated residue. Furthermore, our peptide array experiments not only identified multiple peptide sites on MST1 that can inter- act with MOB1B in a phosphorylation-dependent manner, they also revealed a hydrophobic stretch ...
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Fascin induces melanoma tumorigenesis and stemness through regulating the Hippo pathway
... It has previously been shown that the level of TAZ was much higher than YAP in melanoma [16], implying that TAZ is a primary effector of the Hippo pathway in melanoma. To examine if TAZ affects melanoma ...
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The role of the Hippo pathway in human disease and tumorigenesis
... Though Hippo signaling converges on a singular out- put of YAP/Yorkie translocation to the nucleus, a variety of upstream signals converge on the core MST1/2 kinase cassette to input into the Hippo ...core ...
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Hippo pathway regulation by cell morphology and stress fibers
... the Hippo pathway by cell morphology ...the Hippo pathway upstream of or at Lats, thereby reducing Yap phosphorylation and promoting nuclear Yap ...activates Hippo and ...
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New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
... of Hippo signaling pathway has been linked to a variety of critical biological processes and human diseases, including organ growth control, stem cell func- tion, tissue regeneration and tumor ...the ...
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The Hippo pathway in disease and therapy: cancer and beyond
... Although Hippo signalling activities are clearly al- tered in human cancers, only few germline and somatic mutations of Hippo signalling components have been described so far, with the exception of YAP/TAZ ...
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Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway
... the Hippo pathway and a consequential enhancement of nuclear translocation of YAP by sequestration of KIBRA from its canonical KIBRA/Merlin/FRMD6 complex, we at- tempt to investigate potential downstream ...
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The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish
... The Hippo signaling pathway is known for its role in modulating myocardial growth (Heallen et ...the Hippo pathway and its transcriptional effectors in cardiac trabeculation in mouse and in ...
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The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish
... Here, we investigate the role of the Hippo pathway effector Taz, encoded by the WW domain-containing transcription regulator protein 1 gene (wwtr1), in zebrafish oogenesis. We show that wwtr1/taz mutant ...
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Deregulation Of The Hippo Pathway Suppresses Differentiation And Promotes Sarcomagenesis
... the Hippo signaling pathway is silenced in UPS, which allows for uncontrolled activation of YAP1 (Eisinger-Mathason et ...to Hippo pathway kinase deletion and epigenetic silencing of its ...
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S100A7 induction is repressed by YAP via the Hippo pathway in A431 cells
... YAP is an oncogenic transcriptional co-activator and is inhibited by the Hippo pathway. Recent studies have revealed that YAP is also a sensor of cell morphology and cell density and can be phosphorylated ...
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Alveolar rhabdomyosarcoma–associated PAX3 FOXO1 promotes tumorigenesis via Hippo pathway suppression
... the Hippo pathway tumor suppressor ...downstream Hippo pathway target Yes-associated protein 1 (YAP), which is ordinarily restrained by Hippo signaling, was upregulated in RMS ...that ...
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The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
... The mechanical signals directed by TAZ/YAP are important biologically, as they influence cell fate decisions, the best-described example of which is the specification of mesenchymal stem cell (MSC) fate (Fig. 3) (Dupont ...
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The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena
... a Hippo/Mst ...the Hippo pathway maintains an equatorial position of the fi ssion zone, and, by this activity, speci fi es the relative dimensions of the anterior and posterior daughter ...
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FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools
... discovered Hippo signalling ...the Hippo pathway by dFat prevents the transcriptional activation of genes such as CyclinE and Diap1 that promote cell proliferation and prevent apoptosis (Wu et ...The ...
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Awakening the regenerative potential of the mammalian retina
... core Hippo pathway players, a variety of other pathways and molecules crosstalk with the Hippo pathway and may thus influence MG-mediated retinal regeneration (Ma et ...One pathway of ...
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Yorkie Facilitates Organ Growth and Metamorphosis in Bombyx
... The Hippo pathway, which was identified from genetic screens in the fruit fly, Drosophila melanogaster, has a major size-control function in ...the Hippo pathway, including the transcriptional ...
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Original Article Role of miR-129 in myocardial cells of hypertensive heart disease mouse
... nal pathway, p38 pathway, JNK pathway and Hippo pathway (data not ...signal pathway, p38 pathway, or JNK pathway was not activated either by overex- pression of ...
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Original Article Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia
... the hippo pathway, which mainly comprises mammalian STE20-like protein kinase 1/2 (MST1/2), Salvador family WW domain contain- ing 1 (SAV1), large tumor suppressor 1/2 (LATS1/2), Mps one binder (MOB1), ...
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Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling
... the Hippo pathway have been identified (Grusche et ...for Hippo pathway activity (McCartney et ...promotes Hippo activity (Baumgartner et ...the Hippo signaling pathway ...
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