Hippo Signaling
Hippo signaling: growth control and beyond
... cell-to-cell signaling is required to regulate cell proliferation as a function of organ ...the Hippo pathway as a key regulator of organ growth in Drosophila has generated much excitement, as it provides ...
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Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β catenin signaling
... of Hippo signaling in the developing lung, it remains unclear how the Hippo signaling cascade is turned on and off or how its signaling strength is ...the Hippo signaling ...
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RNF181 modulates Hippo signaling and triple negative breast cancer progression
... The Hippo signaling was shown to play impor- tant role in organ size control ...of Hippo signaling includes MST1/2, LATS1/2, YAP, TAZ and ...When Hippo signaling is activated ...
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Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
... The Hippo signaling pathway appears to be conserved in ...multiple Hippo pathway-component counterparts, and some of them rescued fly mutants and/or showed similar activities in flies (Lai et ...and ...
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Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway
... Taken together, we found that in vitro hAD-MSC-differentiated adipocytes could secrete exosomes which are actively taken up by breast can- cer cell line MCF7 and subsequently promote breast cancer cell MCF7 proliferation ...
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The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma
... upstream signaling that regulates WWTR1 may play a key role in promoting WWTR1-mediated meta- static effect ...the Hippo kinase cascade or the non-Hippo signaling path- way regulates the WWTR1 ...
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Regulation of Drosophila glial cell proliferation by Merlin Hippo signaling
... the Hippo pathway and its transcriptional co-activator Yorkie in controlling Drosophila glial ...Merlin-Hippo signaling pathway, whereas the upstream Hippo pathway regulators Fat, Expanded, ...
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Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling
... the Hippo pathway have been identified (Grusche et ...for Hippo pathway activity (McCartney et ...important signaling mediators at the membrane-cytoskeleton interface (McClatchey and Fehon, ...
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Hippo signaling is required for Notch dependent smooth muscle differentiation of neural crest
... Notch signaling has well-defined roles in the assembly of arterial walls and in the development of the endothelium and smooth muscle of the ...vasculature. Hippo signaling regulates cellular growth ...
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Original Article Knockdown of miR-572 suppresses cell proliferation and promotes apoptosis in renal cell carcinoma cells by targeting the NF2/Hippo signaling pathway
... of Hippo signaling in multi- ple biological processes ...NF2/Hippo signaling pathway, by analyzing the phosphorylation of mammalian Ste20-like Kinase 1 ...anti-miR-572-triggered Hippo ...
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WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer
... important Hippo regulator, and its target protein CTGF in WWC3-overexpressed and -depleted cells was ...of Hippo signaling leads to YAP upregulation, which induces binding of TEAD to target gene ...
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Hippo signaling components, Mst1 and Mst2, act as a switch between self renewal and differentiation in Xenopus hematopoietic and endothelial progenitors
... ABSTRACT Hippo signaling is a conserved pathway that regulates cell proliferation and organ size ...of hippo and as core kinases of the Hippo pathway in ...
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Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway
... mammalian Hippo pathway, there are four core kinase cassette components: kinases MST1/2 and LATS1/2, as well as the adaptor proteins SAV1 and MOB1 ...the Hippo kinase cassette tightly balances YAP and TAZ ...
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LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling
... found that the Hippo signaling pathway played import- ant roles in HCC invasion and metastasis. Interestingly, knockdown of LMO3 in MHCC-97H or SMMC-7721 cells significantly increased the phosphorylation of ...
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The hippo signaling pathway: implications for heart regeneration and disease
... of Hippo signaling compo- nents between Drosophila and ...mammalian Hippo signaling involves the activation of a conserved kinase cascade that ultimately phosphorylates the transcription ...
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Original Article miR-135b-5p regulates human mesenchymal stem cell osteogenic differentiation by facilitating the Hippo signaling pathway
... The Hippo signaling pathway, an evolutionarily conserved pathway that controls tissue growth by the regulation of cell proliferation, differenti- ation, and death, has been connected to integ- rin-dependent ...
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The dynamics of Hippo signaling during Drosophila wing development
... (AEL)]. Hippo signaling regulates Yki by controlling its localization, and the relative fraction of nuclear Yki is an indicator of Yki activity (Dong et ...
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Potential Role of Hippo Signaling Pathway in Gastric Cancer
... The Hippo signaling pathway has been demonstrated to play a central role in the development and regulation of tissues and organ ...of Hippo signaling leads to a concurrent combination of ...
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Hippo signaling impedes adult heart regeneration
... that Hippo signaling inhibits cardiomyocyte proliferation during development to control heart size (Heallen et ...major Hippo effector molecule during cardiomyocyte development (Xin et ...between ...
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Active epithelial Hippo signaling in idiopathic pulmonary fibrosis
... the Hippo signaling pathway play diverse roles in organogenesis and oncogen- ...the Hippo kinases, Yap/Taz translocate to the nucleus where they interact with transcriptional cofactors TEAD1–4 to ...
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