Hippo/Yap
<p>miR-520b Promotes Breast Cancer Stemness Through Hippo/YAP Signaling Pathway</p>
... In Hippo/YAP signaling, LATS2 is activated by MST1/2-induced phosphorylation and then phosphorylates and inhibits YAP-mediated gene tran- scription; most of YAP target genes positively ...
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WWC3 inhibits epithelial–mesenchymal transition of lung cancer by activating Hippo-YAP signaling
... and YAP, the mutant lacking a WW domain, which was unable to interact with LATS1 and abrogated this role (Figure ...silencing YAP could reverse the EMT molecular changes caused by the WWC3 knock- down ...
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MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma
... of YAP in Hippo pathway, LATS1 can reduce the level of phosphorylation of ...and YAP were de- tected by Western ...while YAP, the substrate of LATS1, was de- graded by LATS1 phosphorylation, ...
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PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway
... The Hippo pathway was initially defined by genetic studies in Drosophila, wherein mosaic mutations of Hippo pathway genes resulted in tissue overgrowth ...the Hippo pathway, a conserved kinase ...
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MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway
... Results: We found that miR-591 expression levels were significantly downregulated in breast cancer tissues com- pared to adjacent normal tumor tissues. Lower miR-591 expression notably related to lymph node metastasis ...
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Original Article Hippo-YAP signaling pathway is associated with the prognosis in children with osteosarcoma
... of YAP leads to its cytoplasmic retention and/or degradation, depending on the sites of phosphorylation [10, ...the Hippo signaling can lead to organ overgrowth and induce tumors in model organisms ...the ...
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Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression
... The Hippo-YAP pathway plays a critical role in stem cell[93] and cancer stem cells[94, ...and Hippo-YAP pathways, whereby it promotes the phosphorylation of AKT and ERK but inhibits the ...
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Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
... phosphorylating YAP at Ser127 or TAZ at Ser89. Phosphorylated YAP then binds to 14-3-3 protein and remains in the cytoplasm for degradation ...Dephosphorylated YAP translocates into the nucleus and ...
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Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer
... the Hippo/YAP signaling pathway, we hypothesize that miR-195-5p may function by targeting the YAP1 ...that YAP and its transcriptional coactivator with PDZ-binding motif (TAZ) function as a nexus on ...
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<p>Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis</p>
... of Hippo/YAP signaling in glioma cell proliferation and apoptosis under irradiation ...of YAP can signi fi - cantly enhance the radiosensitivity of glioma ...
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Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells
... regulates YAP stability is not clear. In the Hippo pathway, YAP is negatively regulated by a core cassette consisted of LATS1, LATS2, MST1, and MST2 kinases [17, 23, ...with YAP expression ...
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S100A7 induction is repressed by YAP via the Hippo pathway in A431 cells
... to YAP inactivity. We hypothesized that YAP may function as a repressor of S100A7 induction in A431 ...overexpressed YAP wild type (YAP-WT) and YAP Serine 127 to alanine mutant ...
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Prognostic value of the Hippo pathway transcriptional coactivators YAP/TAZ and β1-integrin in conventional osteosarcoma
... Recently, some studies have reported high expression of YAP1 in osteosarcoma specimens with subsequently a higher expression of target genes related to the Hippo pathway [13, 14, 25]. When YAP1 was knocked down by ...
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Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP
... binds YAP, a major effector of Hippo signaling, to regulate ...characterize YAP as a target of middle T antigen (MT) important for ...the YAP WW domains. Mutation of either R103 or D182 of MT ...
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The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma
... of Hippo signaling induces a kinase- signaling cascade leading to the phosphorylation of conserved serine residues in ...that YAP associated differentially with different NOS1AP isoforms, we next wanted to ...
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Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
... the Hippo pathway is extensively associated with the function of non-neoplastic cells involved in the so-called tumor-stroma interplay, we envisioned a role for the Hippo signal in this ...between ...
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Original Article MST1 inhibits cell proliferation and invasion of non-small-cell lung cancer by regulating YAP phosphorylation and Hippo pathway
... and Hippo pathways in different cells respec- tively [5, ...than YAP phos- phorylation [5]. Overexpression and nuclear location of YAP in non-small-cell lung cancer (NSCLC) has been well documented ...
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Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer
... between YAP and breast cancer cell aggressiveness ...of YAP has been shown to be a trigger of epithelial–mesenchymal transition [43] and actin dynamics ...the Hippo pathway, activation of YAP ...
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The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer
... or YAP, and CTGF may have inferior survival compared with their negative ...the Hippo pathway in ...and YAP/CTGF phenotypes were predictive of overall survival in: i) patients whose tumors displayed ...
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The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
... studying Hippo signaling in vivo. Expression of Yap, or of a constitutively nuclear mutant, from a kidney-specific inducible promoter was observed to increase liver mass following only 3 days (Camargo et ...
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