Hippo-YAP/TAZ pathway
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
... studying Hippo signaling in vivo. Expression of Yap, or of a constitutively nuclear mutant, from a kidney-specific inducible promoter was observed to increase liver mass following only 3 days (Camargo et ...
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Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer
... of TAZ, Vimentin, ZEB2, and SMAD3 protein were also negatively regulated by miR-195-5p, while E-cadherin was positively regulated by miR-195-5p, suggesting the negative regulations of miR- 195-5p on the ...
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The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer
... Deregulated Hippo pathway promotes oncogenic functions in female breast ...the Hippo transducers TAZ/YAP and their target CTGF in ...for TAZ, YAP and ...between ...
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Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
... for Hippo signaling in the epicardium in suppressing the post-infarct inflammatory response through recruitment of ...epicardial YAP and TAZ, two core Hippo pathway effectors, developed ...
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Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ
... the Hippo pathway also con- trols organ size, tissue homeostasis, and stem cell self- renewal [10, ...the Hippo signaling pathway is observed in many human cancers, which play a key role in ...
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MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway
... In the present study, we have ascertained novel molec- ular mechanisms miR-591 inhibited cell proliferation and invasion in breast cancer. We found that miR-519 expression was low in breast cancer tissues and cells. ...
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LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway
... MARK4, YAP and TAZ mRNA transcript levels caused by LINC00673 knockdown ...and YAP/TAZ and the increase phosphory- lated YAP protein expression was also abolished by miR- 515-5p ...
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Prognostic value of the Hippo pathway transcriptional coactivators YAP/TAZ and β1-integrin in conventional osteosarcoma
... of YAP: YAP expression induced epithelial- mesenchymal transition, abolished apoptosis and promoted proliferation ...[3]. YAP expression is also linked to oncogenic properties in several human ...
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Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
... phosphorylating YAP at Ser127 or TAZ at Ser89. Phosphorylated YAP then binds to 14-3-3 protein and remains in the cytoplasm for degradation ...Dephosphorylated YAP translocates into the ...
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RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
... co-activators YAP and TAZ 14,15 ...shape. YAP and TAZ are two transcriptional co-activators that are regulated by the Hippo signalling pathway 14,15 ...
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Original Article Hippo-YAP signaling pathway is associated with the prognosis in children with osteosarcoma
... ing YAP at Ser127 or TAZ at Ser89, then acti- vate expression of target genes regulating cell proliferation, differentiation, and apoptosis [16- ...cofactor YAP does not con- tain its own DNA-binding ...
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TAZ and YAP are frequently activated oncoproteins in sarcomas
... Hippo pathway. This is supported by other studies that demonstrate TAZ and YAP stimulate the development of certain connective tissues/organs and are oncogenic drivers of mesenchymal ...[22]. ...
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The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish
... of Taz, that make an FC differentiate into the very specialized MC? There are two major differences between these two related cell types: their size and their ...signaling pathway (reviewed by Lloyd, ...of ...
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PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway
... The Hippo pathway was initially defined by genetic studies in Drosophila, wherein mosaic mutations of Hippo pathway genes resulted in tissue overgrowth ...the Hippo pathway, a ...
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Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse
... the Hippo pathways, YAP and its paralog TAZ (transcriptional co-activator with PDZ-binding motif) are two critical oncogenic components acting through their interactions with transcriptional enhancer ...
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Original Article Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia
... mammals, YAP is the key functional effector of the hippo pathway, which mainly comprises mammalian STE20-like protein kinase 1/2 (MST1/2), Salvador family WW domain contain- ing 1 (SAV1), large tumor ...
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Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
... the Hippo pathway is extensively associated with the function of non-neoplastic cells involved in the so-called tumor-stroma interplay, we envisioned a role for the Hippo signal in this ...between ...
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Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first line chemotherapy
... between Hippo and the Wnt pathway ...between Hippo and Wnt prevalently takes place at the level of β-catenin regula- tion [22, ...of YAP/ TAZ in the β-catenin destruction complex ...Wnt ...
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YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
... The Hippo pathway is a key upstream regulator of YAP/TAZ, limiting its activity through phosphorylation-dependent cytoplasmic retention and destabili- zation (6, ...that YAP/ TAZ ...
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Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators
... promoted YAP protein level by activating YAP transcription ...or TAZ revealed that 74% of β-catenin target genes are also dependent on TAZ ...suggest TAZ as a fundamental effector of ...
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