Hippocampal Synaptic Plasticity
Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice
... Hippocampal synaptic structure and function are always linked to brain cognition [ 20 , 21 ...brain synaptic functions including electrical or chemical signal transmission and therefore may lead to ...
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The Regulation of Hippocampal Synaptic Plasticity by Upstream and Downstream Effectors of Histone Acetylation
... of Hippocampal Synaptic Plasticity by Upstream and Downstream Effectors of Histone Acetylation Abstract Long-lasting forms of hippocampal plasticity and hippocampus-dependent memory ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... This seems indeed to be the case in global IRS-2 KO mice, where activation of MAPK was not sustained 30 min after the induction of LTP [94]. The multifunctional enzyme GSK-3 has recently emerged as a regulator of ...
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Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a.
... on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly ...induces hippocampal insulin resistance leading to FoxO3a-mediated over- expression of the ...
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Original Article Sevoflurane exposure induces short-term impairment of hippocampal synaptic plasticity in aged rats
... of hippocampal LTD The LTD at hippocampal CA3-CA1 synapses in aged rats was also evaluated in the Sevo 24 group and Sevo 72 ...at hippocampal synaptic plasticity in aged ...
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Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats
... activity-dependent synaptic plasticity reported here could be explained by an insufficient dose or duration of the hormonal ...activity-dependent synaptic plasticity after thyroid hormone ...
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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
... elevated synaptic glutamate level that results from astrocytic glutamate upon PAR1 ac- ...in synaptic glutamate concentration, we compared the increased τ decay of AMPAR-EPSCs by PAR1 activation in Best1 KO ...
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Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1
... Mice expressing the ABCG1 BAC transgene were next eval- uated against wild-type littermates on the Morris Water Maze spatial reference memory task. The task consisted of a 5-day acquisition phase in which mice were given ...
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Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression
... of hippocampal LTP, synaptic plas- ticity, and ...that hippocampal CREB was downregu- lated in depressed ...downregulated hippocampal p-CREB levels without chang- ing CREB levels in depressed ...
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Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity.
... Animals and experimental groups. For all experiments, 8-week-old female C57Bl/6J mice were pur- chased from Elevage Janvier (Le-Genest Saint-Isle, France), and handled for a week before experiments started. Before ...
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Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity
... In the current study, we tried to understand the roles of the RAR/RXR signaling pathway in hippocampus- dependent learning and memory and in hippocampal synaptic plasticity. To do this, we generated ...
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The organization of proteins involved in synaptic plasticity
... Yudowski GA, Puthenveedu MA, Leonoudakis D, Panicker S, Thorn KS, Beattie EC, von Zastrow M. 2007. Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors. J Neurosci. 27:11112-21. ...
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Modulation of synaptic plasticity by hippocampal theta rhythm
... to synaptic excitability, we evoked population spikes by single-pulse stimulation of basal and apical dendritic synapses during different phases of theta ...
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Interactions between Hebbian and Homeostatic Synaptic Plasticity in Hippocampal Circuits.
... of synaptic plasticity can endure for months in vivo (Abraham et ...Hebbian plasticity would suppress or constrain the magnitude of local homeostatic plasticity that would oppose the Hebbian ...
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Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus
... use-dependent plasticity of mammillothalamic synapses, which is ...thalamocortical synaptic transmission undergoes potentiation mediated by TrkB receptors (Tsanov and Manahan-Vaughan, ...of ...
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Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin
... of synaptic transmission and long- term changes in synaptic morphology associated with memory ...acute hippocampal slices and primary hippocampal neuronal cultures showed that basal ...
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Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway
... normal synaptic function of Presenilins and the dysfunction of Presenilin mutations all focused on the hippocampal Schaffer collateral path- ...other hippocampal synapses, such as the mossy fiber ...
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Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Hippocampal Structural Synaptic Plasticity in Rats
... LI L, YIN Z, HUO X: The influence of low-frequency rTMS on EEG of rats. Neurosci Lett 412: 143-147, 2007. LI Y, HUO X, SONG T: The effects of chronic repetitive transcranial magnetic stimulation on glutamate and gamma- ...
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Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice
... the hippocampal synaptic proteins (SYN and PSD-95), neuroglial cell markers (CD11b and GFAP), the pro- inflammatory transcription factor, NF-κB p65, and cy- tokines (IL-1β, TNF-α and IL-6) were also ...
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Caspases in synaptic plasticity
... in synaptic plasticity, inde- pendent of neuronal cell ...lasting synaptic plasticity in hip- pocampal ...of synaptic strength, but the mechanism of how caspase-3 controls AMPA receptor ...
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