histidine-rich protein
Value of Plasmodium falciparum histidine-rich protein 2 level and malaria retinopathy in distinguishing cerebral malaria from other acute encephalopathies in Kenyan children.
... Histidine-rich protein 2 (HRP2) is secreted by Plasmodium falciparum throughout its 48-hour cycle and remains intraery- throcytic until mature schizonts release it into blood ...
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Combining Parasite Lactate Dehydrogenase Based and Histidine Rich Protein 2 Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia
... Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmod[r] ...
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Plasmodium falciparum Histidine Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis
... (11). Histidine-rich protein II (HRPII) is a unique protein produced exclusively by ...is histidine, and repeats of histidine plus alanine cover 85% of ...
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Plasmodium falciparum histidine rich protein 2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana
... Keywords: Malaria diagnosis, Plasmodium falciparum, Rapid diagnostic test RDT, Plasmodium falciparum histidine rich protein-2 PfHRP-2, Plasmodium falciparum histidine rich protein-3 gen[r] ...
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Evidence for histidine rich protein 2 immune complex formation in symptomatic patients in Southern Zambia
... falciparum histidine-rich protein 2 (HRP2), which was the first antigen targeted in com- mercial tests ...water-soluble protein found in the parasite and host erythrocyte cytoplasm and on the ...
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Effect of Sequence Variation in Plasmodium falciparum Histidine Rich Protein 2 on Binding of Specific Monoclonal Antibodies: Implications for Rapid Diagnostic Tests for Malaria
... arum, termed histidine-rich protein 2 (HRP2). While these tests do not detect infection with other malaria species, RDTs targeting P. falciparum HRP2 (PfHRP2) have been reported to display high ...
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Malaria surveys using rapid diagnostic tests and validation of results using post hoc quantification of Plasmodium falciparum histidine rich protein 2
... an estimated 314 million tests procured in 2015, the vast majority of these tests designed to detect the Plasmo- dium falciparum histidine-rich protein 2 (HRP2) [1]. This practical tool has allowed ...
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In vivo compartmental kinetics of Plasmodium falciparum histidine rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine rich protein II
... curve and linear regression analysis. Protein half-life was determined using a first-order decay equation. For the comparison between splenic and asplenic mice, data were normalized to percent of total remaining. ...
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Cerebrospinal fluid Plasmodium falciparum histidine rich protein 2 in pediatric cerebral malaria
... malaria, is a water-soluble parasite-specific protein released from parasite-infected erythrocytes. PfHRP-2 is produced throughout the parasite’s 48-h life cycle, with approximately 90% released at the moment of ...
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Identification of Plasmodium falciparum histidine rich protein 2 in the plasma of humans with malaria
... Thus, by dot blot analysis, PfHRP-2 could be detected routinely in the plasma of patients with malaria, but not in the control samples.. Results of Western blotting studies.[r] ...
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Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante Akim, Ghana
... antigens, histidine-rich protein-2 (HRP2), lactate dehydrogenase (LDH) and aldolase, which distinguish the differences in the sensitivity and specificity seen in RDT test kits ...produces ...
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A cross sectional study of asymptomatic Plasmodium falciparum infection burden and risk factors in general population children in 12 villages in northern Uganda
... malaria histidine-rich protein 2 (Pf-HRP2) and the pan-lactate dehydrogenase (pLDH) antigen and have a reported sensitivity and spec- ificity of 92–100% in Uganda ...
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A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial
... knob-associated histidine-rich protein; MCB: master cell bank; FDA: Food and Drug Administration; CHMI: controlled human malaria infection; dhfr: human dihydrofolate reductase; 5-FC: ...
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False negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission
... Keywords: Malaria, Plasmodium falciparum, Rapid diagnostic test RDT, Histidine rich protein 2 HRP2, Plasmodium lactate dehydrogenase pLDH, Sensitivity, Polymerase chain reaction PCR, Rwa[r] ...
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Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, Honduras
... the histidine-rich protein 2 (PfHRP2) gene ( pfhrp2 ) in field isolates of Plasmodium falciparum , which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) ...
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Accuracy of Pf HRP2 versus Pf pLDH antigen detection by malaria rapid diagnostic tests in hospitalized children in a seasonal hyperendemic malaria transmission area in Burkina Faso
... arum histidine-rich protein-2 (PfHRP2)-detecting RDTs [4,5], which is most probably due to PfHRP2 persistence after clearance of infection ...
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Placental Plasmodium falciparum malaria infection: Operational accuracy of HRP2 rapid diagnostic tests in a malaria endemic setting
... However, malaria rapid diagnostic tests (RDTs) may provide a solution as emerging evidence suggests that RDTs are capable of detecting placental malaria better than microscopy and may detect sub-microscopic infec- tions ...
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Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
... Background: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The ...
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Performance comparison of CareStart™ HRP2/pLDH combo rapid malaria test with light microscopy in north western Tigray, Ethiopia: a cross sectional study
... of histidine-rich protein 2 (HRP-2), plasmodium specific lactate dehydrogenase (pLDH) and aldolase antigens [12, ...-specific protein and pan- Plasmodium ...
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Usefulness of Plasmodium falciparum specific rapid diagnostic tests for assessment of parasite clearance and detection of recurrent infections after artemisinin based combination therapy
... on histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens were studied and compared with two microscopy techniques (Giemsa and acridine orange-stained blood smears) and real-time ...
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