histone deacetylase 6
Histone deacetylase 6 in cancer
... transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only participates in histone acetylation and deacetylation but also targets several nonhistone ...
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Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma
... Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being increasingly used in cancer clinical trials due to the direct cytolytic effects of this treatment that appear to provoke a ...
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Tomato Yellow Leaf Curl Virus V2 Interacts with Host Histone Deacetylase 6 To Suppress Methylation-Mediated Transcriptional Gene Silencing in Plants
... benthamiana histone deacetylase 6 (NbHDA6), a homolog of Arabidopsis HDA6 (AtHDA6), known to be involved in gene silencing in cooperation with methyltrans- ferase 1 ...restored histone ...
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Histone deacetylase 6 activity is critical for the metastasis of Burkitt’s lymphoma cells
... Background: Burkitt ? s lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitt ? s lymphoma is poor. ...
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Histone deacetylase 6–mediated selective autophagy regulates COPD associated cilia dysfunction
... Ciliated cells of the respiratory tract have large numbers of motile cilia, each nucleated by a basal body, from which extends the ciliary axoneme (30). Motile cilia are dynamic organelles that depend on ATP-driven motor ...
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Histone deacetylase 6 modulates macrophage infiltration during inflammation
... Histone deacetylase 6 (HDAC6) has recently been identified as an important regulator of cytoskeletal dynamics. It modifies two key cytoskeletal substrates: α-tubulin and cortactin, a filamentous ...
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Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules
... protein, histone deacetylase 6 (HDAC6), inhibits IAV ...about 6-fold more IAV progeny. The deacetylase activity of HDAC6 played a role in its anti-IAV function as tubacin, a specific ...
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Comparative qsar analysis of histone deacetylase 6 (hdac6) inhibitors as anti cancer agents
... cancer drug targets with an ability to reverse abnormal epigenetic states associated with cancer. HDAC6, a subtype of HDAC, functions at the crossroads between atleast two cell signalling pathways involving ...
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The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells
... needed. Histone deacetylase 6 inhibition is considered as a potential therapeutic strategy for acute leukemia, since it is observed that HDAC6 is overexpressed in acute leukemia and regulates tumor ...
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Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant
... Background: We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized ...
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Genetic Control of Developmental Changes Induced by Disruption of Arabidopsis Histone Deacetylase 1 (AtHD1) Expression
... yeast histone deacetylase complexes that regulate silencing and induced by DNA hypomethylation mutation in Arabidopsis thali- ...of histone H4 by ...
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Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
... Glioblastoma multiforme (GBM), which is the most common primary central nervous system malignancy in adults, has long presented a formidable challenge to researchers and clinicians alike. Dismal 5-year survival rates of ...
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Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
... Total HAT activity was measured using a commercially available kit (Histone Acetyltransferase Activity Assay Kit, ab65352, Abcam) according to the detailed instructions pro- vided by the manufacturer. Briefly, 30 ...
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Epigenetic modulators as therapeutic targets in prostate cancer
... of histone 3 (H3K4me3, H3K36me, and H3K79me) are marks of active transcription, whereas methylation of lysines 9 and 27 of histone 3 (H3K9 and H3K27) results in silent chro- matin state [40, ...The ...
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Racial Disparity in Social Spatiality: Usage of National Parks and Opera Attendance
... A number of interacting partners of p68 have been uncovered by previous studies. Calmodulin is reported to interact with p68 at the N-terminus and the interaction affects ATPase activity of p68 (Buelt, Glidden et al. ...
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A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease
... [218]. Histone deacetylase protein Sirtuin 6 (SIRT6) has been implicated in DNA repair and neurodegeneration where the lack of SIRT6 correlates with increased phosphorylation of tau ...
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A Class 1 Histone Deacetylase with Potential as an Antifungal Target
... The high conservation of these two fungus-specific regions prompted us to investigate their relevance for the biological func- tion of the enzyme. To this end, RpdA with N18 or C18 deleted was expressed under the control ...
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Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer
... Figure 10: Dox combined with SAHA or VPA triggers induces histone hypo-acetylation. A. Histones were extracted by acid from the four cell lines (HCT 116 p53+/+, HCT116 p53-/- SW480 and HT-29) after exposure to ...
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A Histone Deacetylase Complex Mediates Biofilm Dispersal and Drug Resistance in Candida albicans
... that histone deacetylase- inhibitory drugs may be useful for inhibition of biofilm dispersal and consequently prevention of the spread of a biofilm infection to new niches within the ...these histone ...
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HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
... siRNA against HDAC1, 2 and 3 led to increased histone acetylation [13]. Using gene expression profiling after specific downregulation of HDAC1, 2 and 3 in HCC cell lines HLE and HLF, we observed an upregulation of ...
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