Histone deacetylase (HDAC)
Histone deacetylase modulators provided by Mother Nature
... between histone acetyltransferase and histone deacetylase (HDAC) ...therapy. Histone deacetylase inhibitors (HDACi) are epigenetically active drugs that induce the hyperacetylation of ...
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Original Article Effect of histone deacetylase on prostate carcinoma
... Abstract: Commonly occurred in aged males, the incidence of prostate carcinoma is increasing by years. Histone deacetylase (HDACs) as one key enzyme in regulating gene transcription has been found to be ...
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Histone deacetylase 6 in cancer
... transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only participates in histone acetylation and deacetylation but also targets several nonhistone substrates, ...
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Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
... Glioblastoma multiforme (GBM), which is the most common primary central nervous system malignancy in adults, has long presented a formidable challenge to researchers and clinicians alike. Dismal 5-year survival rates of ...
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HDACiDB: a database for histone deacetylase inhibitors
... An histone deacetylase (HDAC) inhibitor database (HDACiDB) was constructed to enable rapid access to data relevant to the development of epigenetic modulators (HDAC inhibitors [HDACi]), helping bring ...
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Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer
... of histone deacetylase 2 (HDAC2) and the presence of TP53 mutations with the progression to advanced stage drug resistant colorectal cancer ...of histone acetylation on residues H3K9, H4K12 and H4K16 ...
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Interpreting clinical assays for histone deacetylase inhibitors
... HDAC, histone deacetylase; HDACi, HDAC inhibitor; HL, Hodgkin lymphoma; iL-6, interleukin-6; KTN, karenitecin; LMP, low malignant potential; MDS, myelodysplastic syndrome; MM, multiple myeloma; MTC, ...
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Histone deacetylase 1 interacts with HIV 1 Integrase and modulates viral replication
... that histone deacetylase I (HDAC1) could be such a partner, being incorporated in HIV-1 virions in an integrase-dependent manner as part of the Sin3a-HDAC1 complex ...I histone deacetylase ...
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Effects of the Histone Deacetylase Inhibitor ITF2357 in Autoinflammatory Syndromes
... We explored the effects of the oral histone deacetylase (HDAC) inhibitor ITF2357 in patients with autoinflammatory syndrome. In this prospective open-label pilot study, eight patients were enrolled; one ...
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Targeting Inflammation in Heart Failure with Histone Deacetylase Inhibitors
... molecule histone deacetylase (HDAC) inhibitors block adverse cardiac remodeling in animal models, suggesting unforeseen potential for this class of compounds for the treatment of heart ...
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Hyperphosphorylation of Histone Deacetylase 2 by Alphaherpesvirus US3 Kinases
... Recently, histone deacetylase inhibitor VII, 106 (HDACi VII), a specific HDAC inhibitor that inhibits only class I HDACs (specifically HDAC1, HDAC2, and HDAC3), became available ...
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Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
... by histone or histone- related proteins, such as histone acetylase (HAT) and histone deacetylase ...of histone proteins have been defined to be involved in chromatin remodeling, ...
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Histone Deacetylase 3 indirectly modulates tubulin acetylation
... nuclear histone proteins, hence the name ‘histone’ deacetylase [2], more recently HDACs have also been shown to act on non-histone proteins including cytoplasmic proteins in some cases ...
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Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
... Abstract: Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin-modifying agents) ...
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Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders
... mice. Histone deacetylase enzyme unwinds the DNA for effective gene ...as histone deacetylase inhibitor, prevents the removal of the acetyl group and maintains the structure of DNA but it ...
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A Histone Deacetylase Complex Mediates Biofilm Dispersal and Drug Resistance in Candida albicans
... conserved histone deacetylase complex in ...these histone deacetylase complex members are needed for proper biofilm formation, including dispersal of cells from biofilms and multifactorial ...
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Genetic Control of Developmental Changes Induced by Disruption of Arabidopsis Histone Deacetylase 1 (AtHD1) Expression
... jor histone deacetylase induces pleiotropic effects on plant growth and ...of histone acetylation and similar developmental abnormalities, which are heritable in the presence of antisense AtHD1 or in ...
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Histone Deacetylase Inhibitor Valproic Acid and Cancer [Retracted]
... p21WAF1, which probably combine to modulate the activity of the downstream pRb/E2F axis triggering cell cycle arrest [45]. In vivo study has demonstrated that VPA (20 mg/kg and 40 mg/kg) inhibit histone ...
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Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
... and histone post-translational modification through the use of DNA methylation and histone deacetylase inhibitors has been shown to exert antitumor effects in in vitro and in vivo models ...
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Histone deacetylase inhibitors: clinical implications for hematological malignancies
... This class of HDACis presents a different structure from the other classes because of the 2′-aminoanilide moiety, which can likely function as a weak zinc-chelating group into the tube-like active site of the ...
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