Histone demethylase
Original Article Upregulation of PSMD10 caused by the JMJD2A histone demethylase
... the histone demethylase JMJD2A/ KDM4A and its interaction partner, the ETV1 transcription factor, in LNCaP prostate cancer ...JMJD2A histone demethylase by small molecule drugs may be ...
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The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b
... To investigate the potential role of the histone demethylase PHF8 in human PCa, we first profiled the expression pat- tern of PHF8 in human normal prostate tissues and cancer tissues. We analyzed 19 normal ...
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Penterling, Corina (2019): The effect of depletion of histone demethylase Jarid1A on cell proliferation, histone modifications, radiation response and gene expression. Dissertation, LMU München: Fakultät für Biologie
... of histone demethylase Jarid1A in cell proliferation and radiation response by siRNA-mediated depletion of ...specific histone demethylase Jarid1A removes tri- and di-methylations at ...
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Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1
... Histone demethylase upregulation has been observed in human cancers, yet it is unknown whether this is a bystander event or a driver of ...lysine-specific demethylase 4A (KDM4A, also known as JMJD2A) ...
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Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis
... The histone demethylase PHF8 is physically associated with the deubiquitinase USP7. In order to further explore the biological function of PHF8 and to investigate its role in the development of cancer, we ...
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Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster
... that histone demethylase-inactive Lid flies are short lived [20], whereas another study showed that disruption of Dmel/Kdm4A, a homologue of the human JMJD2 family, reduces male-specific longevity ...
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Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo
... The increased expression of KDM2B in ovarian cancer was associated with histological type, tumor grade, FIGO stage, and lymph node metastasis, and it was positively correlated with EZH2. KDM2B depletion reduced the ...
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Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-Associated Herpesvirus Replication and Is Targeted by a Viral Transcriptional Factor
... of histone codes. Recently, comprehensive analysis of histone modifications of KSHV showed the deposition of H3K27me3 across the KSHV genome with two specific regions occupied by the heterochromatin marker ...
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Histone demethylase dUTX antagonizes JAK STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche
... specific histone demethylase encoded by Ubiquitously transcribed tetratricopeptide repeat gene on the X chromosome (dUTX) maintains active transcription of the Suppressor of cytokine signaling at 36E ...
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Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer
... histone demethylase JARID1C is frequently inactivated in patients with clear cell renal cell carcinoma (ccRCC); however, it is largely unknown how JARID1C dysfunction promotes ...a histone mark ...
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The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3
... the demethylase activity of dKDM5/LID in the observed genetic interac- ...of histone modification pat- terns in Drosophila species have revealed variations in the chromatin landscape between the sexes ...
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The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila
... are histone H3 lysine 4 demethylases that can function through both demethylase-dependent and -independent ...domain-encoded histone demethylase activity of KDM5, suggesting key functions for ...
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The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
... Although MAOIs are very effective in vitro, and they did significantly suppress the growth of neuroblastoma xenograft tumors in mice, their lack of specificity for KDM1A requires treatment with high doses, which cause ...
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Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development
... and histone modifications interact to modulate gene expression in biological ...The histone demethylase IBM1 suppresses DNA methylation and gene silencing, primarily by targeting genic regions in the ...
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Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis
... domain histone H3K36 di-demethylase (H3K36me2), following a genome-wide insertional mutagenesis screen in Moloney murine leukemia virus–induced (MoMuLV- induced) T cell lymphomas (19, ...identified ...
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Maternal expression of the histone demethylase Kdm4a is crucial for pre implantation development
... the histone demethylase Kdm4a is essential for female, but not male, ...in histone states at affected genes are diluted by more abundant uterine cell ...
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Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors
... Kdm3b is a histone H3 demethylase that specif- ically catalyzes the demethylation of H3K9me1/2 [12]. Several studies have associated the role of Kdm3b with cell growth and transformation. Specifi- cally, ...
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Assessing histone demethylase inhibitors in cells: lessons learned.
... FLAG-tagged demethylase (WT) into cells and assaying the cells overexpressing the demethylase for the respective substrate mark in a high-content immuno- fluorescence (IF) ...
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Fine-Tuning of Histone H3 Lys4 Methylation During Pseudohyphal Differentiation by the CDK Submodule of RNA Polymerase II
... are histone post-translational ...the histone demethylase JHD2 are required to inhibit pseudohyphal growth—a differentiation pathway induced during nutrient limitation—under rich ...
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
... DNMT3). Histone methylation, a mechanism to modify chromatin structure, dynamically regulates cellular processes including transcription and genomic ...ago, histone methylation was considered an immutable ...
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