Histone H2A
Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
... of H2A deposition in early embryos likely has strong roles in regulating pluripotency and dif- ferentiation ...canonical H2A is consistent with the observation in mouse embryos and stem ...the ...
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PHF7 is a novel histone H2A E3 ligase prior to histone to protamine exchange during spermiogenesis
... ubiquitylate histone H2A in vitro . (A) Western blot of ub-H2A, ub-H2B and H4K16Ac in spermatids from 8-week-old mice, with H3K27me3 serving as a loading ...ubiquitylate H2A and ...
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Saccharomyces cerevisiae Histone H2A Ser122 Facilitates DNA Repair
... Figure 1.—Histone H2A S122 is important for sur- vival in the presence of MMS. (A) Schematic showing the amino acid sequence of the S. cerevisiae histone H2A C-terminal tail. Residues that ...
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Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1
... Anti-Ubiquityl-Histone H2A (Lys119) (D27C4) XP rabbit mAb (Cell Signaling Technology, 8240), ChIPAb + EZH2 (clone AC22, MilliporeSigma, 17-662), ChIPAb + Trimethyl-Histone ...
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Multiple Roles for Saccharomyces cerevisiae Histone H2A in Telomere Position Effect, Spt Phenotypes and Double-Strand-Break Repair
... In this study, we demonstrate a role for the amino and carboxyl tails of histone H2A in telomeric silencing, a property not shared by histone H2B (Thompson et al. 1994). This represents the first ...
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Changes in the nuclear deposition of histone H2A variants during pre implantation development in mice
... total H2A content (Mannironi et ...most H2A occurs in the form of ...canonical histone H2A is replaced by ...major H2A proteins are more similar to the mammalian ...canonical H2A ...
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Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer
... tone H2A- and H2B-containing module was associated with epirubicin resistance and that small-molecule inhibi- tors targeting histone pathways induced cytotoxicity in all epirubicin-resistant cell ...the ...
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Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression
... transcription complexes regulate histone modifica- tion to influence stem cell fate. Polycomb group com- plexes (PRC) play critical regulatory roles that change the expression of numerous genes during neuronal ...
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The many faces of ubiquitinated histone H2A: insights from the DUBs
... for H2A/H2AX ubiquitination in the response to DSBs ...which H2A and H2AX ubiquitination (Figure ...Besides histone ubiquitination, ubiquitin signaling at IRIF likely com- prises a complex variety of ...
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Histone H2A Significantly Enhances In Vitro DNA Transfection
... Histones were diluted in sterile endotoxin-free water to a final concentration of 1 mg/ml.. The polycations poly- L-Lys and poly-L-Arg were diluted in sterile en- dotoxin-free water to a[r] ...
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Bönisch, Clemens (2012): Structure/function analyses of mammalian histone H2A and H3 variants. Dissertation, LMU München: Fakultät für Biologie
... other histone variant showed a similar effect on the expression of cell cycle–related genes after RNAi depletion: knockdown of the linker histone variant ...
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Multicomponent Chimeric Antigen for Serodiagnosis of Canine Visceral Leishmaniasis
... In this work, we describe the assembly of a synthetic gene coding for several antigenic determinants found in different Leishmania infantum antigens. Selected epitopes were derived from the ribosomal proteins LiP2a, ...
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The SONBNUP98 Nucleoporin Interacts With the NIMA Kinase in Aspergillus nidulans
... Figure 4.—sonB1 HU sensitivity is not due to a defect in the slowed S-phase checkpoint pre- venting mitosis before completion of DNA repli- cation. (A) Colony-growth phenotypes of a wild- type (R153), sonB1 (CDS40), and ...
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Two Hybridization Events Define the Population Structure of Trypanosoma cruzi
... tone H2A, multiple alleles were captured showing af- finity with DTUs IIb or IIc or a third class of sequences that were mosaic for SNPs of DTU IIb and IIc (see ...H3, H2A, and H2B from the Tula strain; ...
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Effects of orally applied butyrate bolus on histone acetylation and cytochrome P450 enzyme activity in the liver of chicken – a randomized controlled trial
... The present study indicated that (1) orally applied butyr- ate in bolus had an impact on chromatin structure of hepatocytes in chicken in the early post-hatch period: in- dependently of the dose, butyrate caused ...
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Hondele, Maria (2013): An integrated view of the essential eukaryotic chaperone FACT in complex with histones H2A-H2B. Dissertation, LMU München: Medizinische Fakultät
... abundant histone H2A–H2B ‘evicting’ [29] chaperone that can reorganize nucleosomes during transcription, replication and in addition has quite specialized ...the histone H3–H4 globular domains fold ...
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Construction of Comprehensive Dosage-Matching Core Histone Mutant Libraries for Saccharomyces cerevisiae
... hand, H2A D91E was lethal, indicating that charge is not the sole determinant of lethality at this particular posi- ...among histone–histone interaction surfaces (Figure 3F and Figure S6 in File ...
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Residues in the Nucleosome Acidic Patch Regulate Histone Occupancy and Are Important for FACT Binding in Saccharomyces cerevisiae
... While histone proteins have an overall positive charge to facilitate efficient binding to DNA, there is a region on the surface of the nucleosome deemed the “acidic patch” that is formed by multiple aspartic and ...
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Distinctive patterns of epigenetic marks are associated with promoter regions of mouse LINE-1 and LTR retrotransposons
... histones H2A, H2B, H3 and H4 wrapped around genomic DNA. Changes in histone composition and nucleosomal structure are critical in facilitating DNA replication and transcription ...core histone ...
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Genetic Analysis of Saccharomyces cerevisiae H2A Serine 129 Mutant Suggests a Functional Relationship Between H2A and the Sister-Chromatid Cohesion Partners Csm3–Tof1 for the Repair of Topoisomerase I-Induced DNA Damage
... Csm3, Mrc1, and Tof1 were originally identified as checkpoint proteins involved in transmitting the DNA replication arrest to downstream effectors (A lcasabas et al. 2001; F oss 2001; T anaka and R ussell 2001; T ong et ...
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