HIV-1 envelope protein
Efficient trapping of HIV 1 envelope protein by hetero oligomerization with an N helix chimera
... biotin-labeled HIV-1 Env protein, avidin beads were directly added to the labeled cell ...of HIV-1 strain IIIB), or with anti- integrin α 5 (BD Transduction Lab, San Diego, CA) as a ...
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HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission
... The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by ...N-glycans. HIV-1 Env N-glycans shield the ...
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A novel small-molecule inhibitor of HIV-1 entry
... transformed HIV-1 infection into a managed condition with near-normal life ...to HIV-1 resistance, side effects, or drug ...of HIV-1 entry. Compound 5660386 inhibits ...
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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by the gp41 Core: Role of a Conserved Hydrophobic Cavity in Membrane Fusion
... engineered HIV-1 envelope protein ...expressing envelope proteins bearing mutations at Ile 573 (18, ...mutant envelope proteins that are completely defective in mediating ...
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Inhibition of human immunodeficiency virus type 1-induced cell fusion by recombinant human interferons.
... In order to evaluate the effect of IFNs on the cell fusion induced by the HIV-1 envelope protein with another assay system, HeLa T4 cells were cocultivated with HeLa cells infected with [r] ...
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Expression and Immunogenicity of Human Immunodeficiency Virus Type 1 Gag Expressed by a Replication-Competent Rhabdovirus-Based Vaccine Vector
... type 1 (HIV-1) Gag protein was characterized on human cell lines and analyzed for the induction of a cellular immune response in ...expressing HIV-1 ...the HIV-1 ...
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Inhibition of Murine Leukemia Virus Envelope Protein (Env) Processing by Intracellular Expression of the Env N-Terminal Heptad Repeat Region
... that envelope protein was immunoprecipitated by the anti-SU antiserum in all cases, we blotted with anti-HA after immunoprecipitation with ...that envelope protein was immunoprecipitated but ...
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Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120
... recombinant envelope proteins derived from HIV-1 92UG037 (subtype A), IIIB (subtype B), and 92BR025 (subtype C) in the ...Recombinant envelope proteins were captured by immobilized antibody ...
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The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.
... as HIV-2, visna virus, and Moloney murine leukemia virus (5, ...Vpu 1 and Vpu 2 SHIV constructs, designated MD-1 and MD-1 D U, re- spectively ...the HIV-1 DH125 isolate (40) ...
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Generation of Mucosal Anti-Human Immunodeficiency Virus Type 1 T-Cell Responses by Recombinant Mycobacterium smegmatis▿
... insert HIV-1 envelope (env) CON6-gp120 or CON6-gp140CF gene ...the HIV-1 CON6 env gene in the pMV261 and pMV361 vectors is regulated by the Mycobacterium tuberculosis heat shock ...
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Endocytosis Is a Critical Step in Entry of Subgroup B Avian Leukosis Viruses
... type 1 (HIV-1) pseudotyped with the envelope protein of subgroup B ALV (ALV-B) in the presence of three different lysosomotropic ...than HIV-1, which is pH ...
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Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
... neutralized HIV-1 could bind to Env trimers, in contrast to non-neutralizing antibodies, which could bind gp120 monomers, but not trimer ...a HIV-1 gp120 monomer found that residues targeted ...
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Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV 1
... This protein demonstrated the same rate of cytokine release when tested in vitro to the entire wt gp41 (Additional file ...from HIV-1 infected individuals Interestingly, the analysis of the isu ...
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The human immunodeficiency virus (HIV) gag gene product p18 is responsible for enhanced fusogenicity and host range tropism of the highly cytopathic HIV-1-NDK strain.
... Phenotypic analysis of recombinant viruses indicated that 75 aa from the N-terminal part of the HIV-1-NDK p189a9 protein together with the HIV-1NDK envelope glycoprotein are responsible [r] ...
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Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1
... elicit HIV-1-neutralizing antibodies more efficiently than mono- meric gp120 glycoproteins ...gp140(-/FT) protein in rabbits exhibited less outer domain ...OD1 protein adsorbed little of the ...
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Comparison of Western blot (immunoblot) based on recombinant derived p41 with conventional tests for serodiagnosis of human immunodeficiency virus infections
... To evaluate the performance of a serological test for human immunodeficiency virus type 1 HIV-1 infections based on the use of a recombinant envelope gene-derived protein as the antigen,[r] ...
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Recruitment of the Adaptor Protein 2 Complex by the Human Immunodeficiency Virus Type 2 Envelope Protein Is Necessary for High Levels of Virus Release
... the HIV-2 Env defined two func- tional domains in the protein that are required for EVR ac- tivity, a conserved GYxx motif in the membrane-proximal part of the cytoplasmic tail (GYPRV) and an unidentified ...
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HIV 1 envelope, integrins and co receptor use in mucosal transmission of HIV
... that HIV-1 infection typically involves an interaction between the viral envelope protein gp120/41 and the CD4 molecule followed by a second interaction with a chemokine receptor, usually CCR5 ...
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Functional Analysis of the Disulfide-Bonded Loop/Chain Reversal Region of Human Immunodeficiency Virus Type 1 gp41 Reveals a Critical Role in gp120-gp41 Association
... type 1 (HIV-1) entry into cells is mediated by the surface-exposed envelope protein (SU) gp120, which binds to cellular CD4 and chemokine receptors, triggering the membrane fusion ...
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Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope
... that HIV-1 infection can lead to a remod- eling of cellular N-linked glycans, somehow reversing any down- regulation of ...upon HIV-1 infection ...the HIV-1 bnAbs identified thus ...
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