HIV-1/SIV
Mechanistic differences between HIV 1 and SIV nucleocapsid proteins and cross species HIV 1 genomic RNA recognition
... the SIV NC ...either SIV NC were the same within uncertainty (data not ...The HIV-1 Gag protein lacking the p6 domain (HIV-1 Gag∆p6, also referred to simply as “Gag”) was ...
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Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV 1, HIV 2 and SIV reveals an efficient SIV/HIV 2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage
... For HIV-1, sequences between the major splice donor and the start codon of Gag have been shown to be important for efficient packaging ...[8]. HIV-1 may be the exception amongst lentiviruses ...
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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV 1 and SIV infections
... nisms related to immune activation have been suggested to cause the depletion of T cells. We have now iden- tified a mechanism by which immune activation-induced fibrosis of lymphoid tissues leads to depletion of naive T ...
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Alterations in intracellular potassium concentration by HIV 1 and SIV Nef
... Cells of the RH9 subclone of the CD4+ human T-lym- phoblastoid cell line RH9 were the kind gift of Dr. Suraiya Rasheed (University of Southern California), and were maintained in RPMI 1640 supplemented with 10% fetal ...
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Low level alternative tRNA priming of reverse transcription of HIV 1 and SIV in vivo
... the HIV and SIV sequence ...the HIV and SIV database of the Los Alamos National Laboratory ...4 SIV sequences corresponding to PBS-Lys5 were found in the database, compared to 216 ...
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HERV K–specific T cells eliminate diverse HIV 1/2 and SIV primary isolates
... isolates, HIV-1, HIV-2, and SIV viruses, tested, with statistically significant reductions in cells infected with each isolate, except for 99UG_A0848M1 over these 24-hour cocultures (Figure ...
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Conserved Molecular Signatures in gp120 Are Associated with the Genetic Bottleneck during Simian Immunodeficiency Virus (SIV), SIV-Human Immunodeficiency Virus (SHIV), and HIV Type 1 (HIV-1) Transmission
... FIG 2 Alignment of sequence variants in the present study showing the signature sites. For concise illustration, the figure uses a single consensus sequence to represent either the stock or T/F variants in the given ...
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Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.
... type 1 (HIV-1) requires both CD4 and a coreceptor to infect ...(M-tropic) HIV-1 strains utilize the chemokine receptor CCR5 in conjunction with CD4 to infect cells, while T-cell-tropic ...
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Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins
... of HIV-1 reverse transcriptase (RT) while leaving the RNA-dependent DNA polymerase activity intact ...inactivate HIV-1 and SIV ...intact HIV-1 and SIV virions ...
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Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein
... sion vectors. The proper amount of pEF-Flag-HA empty vector (Invitro- gen) was used in the transfection as a control DNA. At 48 h posttransfec- tion, the culture supernatants were harvested and the cells were lysed in ...
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Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins
... of HIV-1 LAI Env (amino acid residues 707 to 856), SIVmac239 Env (residues 716 to 879), and HTLV-1 Env (residues 465 to 488) or the membrane-proximal Tyr-based motifs of the TM-CDs of ...
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Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine
... type 1 (HIV-1) gp120, NefTat fusion protein, and simian immunodeficiency virus (SIV) Nef formulated in the clinically tested adjuvant ...heterologous SIV/HIV strain SHIV ...
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Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... by SIV mac239 Nef and HIV-1 Nef to downregulate class I MHC and found that the ability of SIV Nef to downregulate class I MHC requires a unique C-terminal region of the SIV mac239 Nef ...
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Identification of gp120 Binding Sites on CXCR4 by Using CD4-Independent Human Immunodeficiency Virus Type 2 Env Proteins
... laboratory-adapted HIV-1 isolates as well as many primary HIV-2 and SIV strains do not require CD4 for fusion (32, 36, 38, 47, 52, 56, 68, ...X4-tropic HIV-1 gp120, 8x, have been ...
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Impact of Viral Factors on Very Early In Vivo Replication Profiles in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys
... of HIV are apparently also able to spread more efficiently than their parents (44, 50, ...In HIV-1 and SIVmac infec- tions, mutations in the nef gene are responsible for significant differences in ...
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Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity
... and SIV, respec- tively), have unusually long cytoplasmic domains compared to those of other ...in HIV-1- and SIV-infected cells ...optimal HIV-1 infectivity (10) and for ...
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Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Nef Proteins Show Distinct Patterns and Mechanisms of Src Kinase Activation
... of HIV-1 Nef and SIV Nef on Lck. Although recombinant SIV Nef and HIV-1 Nef did not bind the SH2 domain of Lck unless cell extracts were added, both proteins profoundly altered ...
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Simian Immunodeficiency Virus Engrafted with Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Epitopes: Replication, Neutralization, and Survey of HIV-1-Positive Plasma
... from HIV-positive cohorts or, if such specific- ities do arise, to more accurately determine prevalence among HIV-positive ...that HIV-positive patients generate MPER-specific antibodies directed at ...
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Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
... neutralized HIV-1 could bind to Env trimers, in contrast to non-neutralizing antibodies, which could bind gp120 monomers, but not trimer ...a HIV-1 gp120 monomer found that residues targeted ...
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Isolation and characterization of simian immunodeficiency virus from mandrills in Africa and its relationship to other human and simian immunodeficiency viruses.
... By clone-on-clone hybridization with known retroviruses of the HIV and SIV groups, SIVMND showed similar cross-hybridization with HIV-1, HIV-2, SIVAGM African green monkey-derived SIV, a[r] ...
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