HIV-1 transgenic rats
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats
... of HIV-1 Tg rats were previously associated with neuroAIDS in humans includ- ing IGF binding proteins [41], prostaglandin D2 (PGD2) synthase [42], and the pro-alpha2 chain of type I collagen, Col1A2 ...
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Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats
... alcoholic, HIV-1 transgenic ...control-fed, transgenic rat muscles signifying that chronic alcohol ingestion may be the significant insult that drives myostatin and activin IIB expressions, ...
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RETRACTED ARTICLE: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
... month-old HIV-1 Tg rats to characterize the brain pro- inflammatory microenvironment and synaptic integrity (determined by levels of drebrin and ...these HIV-1 ...
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Anti-inflammatory Function of Phyllostachys Edulis Extract in the Hippocampus of HIV-1 Transgenic Rats
... of HIV-1 transgenic (TG) ...TG rats and 5 Fisher 344 (F344) rats were fed a control diet, another 5 TG rats were fed the control diet supplemented with bamboo extract (BEX, 11 ...
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Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats
... in HIV-1 transgenic ...these transgenic rats (data not shown) suggesting that HIV-1-related protein expression induces systemic atrophy that is neither fiber-type nor ...
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Endotoxin-induced cytokine and chemokine expression in the HIV-1 transgenic rat
... control rats; HAART: Highly active anti-retroviral therapy; HIV-1: Human immunodeficiency virus-1; HIV-1Tg: HIV-1 Transgenic; IACUC: Institutional Animal Care and ...
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CD4-Specific Transgenic Expression of Human Cyclin T1 Markedly Increases Human Immunodeficiency Virus Type 1 (HIV-1) Production by CD4+ T Lymphocytes and Myeloid Cells in Mice Transgenic for a Provirus Encoding a Monocyte-Tropic HIV-1 Isolate
... After rats transgenic for the expression of human CD4/CCR5 were infected with HIV-1, they displayed infection of T lymphocytes that was extremely limited compared to infection of monocytes; ...
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Human cyclin T1 expression ameliorates a T cell specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV 1 strains ex vivo
... early HIV gene expression in primary rat T-cells ...Tat-dependent HIV-1 LTR transactivation may underlie this inefficient viral gene expression in rats as it does in mice ...as HIV ...
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Lack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
... The Tg (n = 3, 10 ± 1 months) and age-matched WT rats (n = 3, 10 ± 0.5 months) were anesthetized with 2–2.5 % isoflurane air/oxygen mixture and injected with 1–2 mCi (37–74 MBq) of [18F]DPA-714 (1.65 ...
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Expression of the Mu Opioid Receptor in the Human Immunodeficiency Virus Type 1 Transgenic Rat Model
... Immunocompromised HIV-positive patients often contract secondary bacterial infections ...Sprague-Dawley rats (30). In this study, we found that in F344 control rats, there were comparable increases ...
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Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo
... type 1 (HIV-1) RNA loads of infected patients that was unexpectedly more rapid than that with a potent reverse transcriptase inhibitor, and apparently dose ...unintegrated HIV-1 cDNAs ...
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Primary T cells from human CD4/CCR5 transgenic rats support all early steps of HIV 1 replication including integration, but display impaired viral gene expression
... the HIV-1 receptor/ coreceptor complex was thought to be very low ...R5 HIV-1 entry in T-cells from hCD4/hCCR5-trans- genic rats and human reference cultures, we employed a sensitive ...
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CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV 1 infection
... targeted HIV genes as well as the cellular molecules critical for HIV entry, namely CD4, CXCR4 and CCR5 ...targeting HIV genes alone will not be sufficient to ward off chronic infection due to the ...
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Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells
... during HIV infection – from interfering with the folding of the normally cytosolic, unglycosylated Nef pro- tein, we inactivated the glycosylation sites by mutagenesis (constructs sp-p27∆gly and sp-p25 ∆gly ...a ...
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First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
... file 1) for verification of loading of an equal amount of sarkosyl-insoluble proteins and efficiency of electroblot- ...for 1 hour at RT and then incu- bated for 1 hour with primary (tau-specific) ...
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Enhanced Replication of Human T-Cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner
... and rats, and their utility is ...nude rats in this model system, better animal models are still ...in rats, which may be one of the reasons why previously established models could not com- pletely ...
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Susceptibility loci for murine HIV associated nephropathy encode trans regulators of podocyte gene expression
... and HIV-1–induced perturbations in these ...chromosome 1 QTL associated with multiple metabolic- and obesity-related traits, where expression traits linking to this interval were decomposed into ...
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The analysis of the in vivo effects of the HIV-1 nef and tat regulatory genes using a transgenic mouse system
... table 1 is readily workable in the developed ...The HIV lab-based "AIDS test" cannot always be used, and the definitive diagnosis of the more complex major indicator diseases of AIDS is ...of ...
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Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1
... in transgenic rats may reflect the activation state adopted by microglia in the dorsal horn of the spinal ...and transgenic rats, with distinct consequences on the severity of pain ...G93A ...
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Transgenic dissection of HIV genes involved in lymphoid depletion
... implicating HIV in inducing T-cell depletion in mice. (A) Despite abundant HIV gene expression during the first 4 wk of life, both the thy- mus and the peripheral lymphoid organs appeared ...by HIV ...
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