Hiv envelope
Antigenic Properties of the HIV Envelope on Virions in Solution
... (HIV) envelope glycoproteins creates a complex relationship between antigenicity and sensitivity to antiviral ...functional envelope structures, neutralized viruses expressing CCR5-tropic envelopes ...
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Effect of HIV Envelope Vaccination on the Subsequent Antibody Response to HIV Infection
... prevent HIV acquisition have been as- sessed in human efficacy ...gp120 envelope (Env) proteins, aimed at inducing antibody responses, were first tested in the VAX003 and VAX004 trials but elicited ...
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Molecular Evolution: The HIV Envelope Protein
... The HIV envelope protein (Env) is essential for binding to a human lymphocyte or T ...but HIV takes advantage of this receptor and uses it to bind to the T ...for HIV infection. This ...
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The frantic play of the concealed HIV envelope cytoplasmic tail
... Rab proteins are early and late-endosome associated GTPases that regulate specific steps in intracellular mem- brane trafficking. They recruit tethering, docking and fu- sion factors, as well as the actin- and ...
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Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
... of HIV env glycoproteins in participants with and without ...against HIV that include targeted diversity within these common sites may thus be critical in the maturation of V1V2- and C3V4-directed ...
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The membrane spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein
... of HIV-1 envelope proteins (Figure 5E and 5F), we did not detect a discernable differ- ence in the distribution between the wild type gp41 MSD (Figure 8 Tac-gp41WT) and 695+2A gp41 MSD ...
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Apoptosis of uninfected cells induced by HIV envelope glycoproteins
... In HIV-infected persons, both infected and uninfected cells undergo accelerated apoptosis, in vitro and in ...of HIV-specific proteins, (ii) activa- tion-induced cell death (AICD), (iii) direct infection of ...
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Effect of nonprotective vaccination on antibody response to subsequent human immunodeficiency virus infection
... with HIV, and at multiple time points in the 9 mo after ...the HIV envelope can alter both the timing and epitope specificity of the subsequent anti- HIV antibody ...
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Excretion of Human Immunodeficiency Virus Type 1 through Polarized Epithelium by Immunoglobulin A
... antigens. HIV-antibody mixtures were added to the basolateral chamber below polarized epithelial cells, with 200 l of medium in the apical ...the HIV envelope protein gene (59), and the 320-bp ...
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Nonneutralizing Functional Antibodies: a New “Old” Paradigm for HIV Vaccines
... of HIV infection, a response that declined rapidly compared to overall IgG responses ...of HIV-1 infection after IgA adjustment ...the HIV envelope V2 loop, al- though with low coverage of ...
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Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
... Inhibition of human immunodeficiency virus HIV infection in vitro by anti-carbohydrate monoclonal antibodies: peripheral glycosylation of HIV envelope glycoprotein gpl20 may be a target [r] ...
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Strategies for an HIV vaccine
... to HIV vaccine design was evaluated in nonhuman primate models, using recombinant HIV envelope glycoprotein as an ...nizing envelope glycoprotein were identical in sequence ...of HIV ...
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Determining Human Immunodeficiency Virus Coreceptor Use in a Clinical Setting: Degree of Correlation between Two Phenotypic Assays and a Bioinformatic Model
... the HIV envelope, in particular, the V3 loop (8, ...of HIV-infected patients faster and more cost- ...for HIV coreceptor usage becomes necessary for treatment with coreceptor inhib- itors, it ...
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Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections
... in HIV-1 envelope-specific serum antibody were evident during the first several months postinfection in both groups of SHIV- infected ...the HIV-1 envelope were detectable in all monkeys by 1 ...
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Expression and Immunogenicity of Human Immunodeficiency Virus Type 1 Gag Expressed by a Replication-Competent Rhabdovirus-Based Vaccine Vector
... expressing HIV-1 ...the HIV-1 envelope protein in mice ...the HIV-1 Gag protein is another important target for cell-mediated host immune ...that HIV-1 Gag can efficiently be expressed ...
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Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
... Most HIV and SIV gp120 subunits have an average of 24 N-linked glycosylation sites (NLGS) and an average of 3 NLGS in the ectodomain of ...from HIV-1 infected patients and SIV-infected rhesus macaques often ...
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HIV 1 envelope, integrins and co receptor use in mucosal transmission of HIV
... that HIV-1 infection typically involves an interaction between the viral envelope protein gp120/41 and the CD4 molecule followed by a second interaction with a chemokine receptor, usually CCR5 or ...an ...
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The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.
... enhance HIV-2 par- ticle release. Such a putative Vpu-like activity of the HIV-2 Env was observed either in the context of the ROD10 mo- lecular clone or when provided in trans to HIV-1/HIV-2 ...
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Release of gp120 Restraints Leads to an Entry Competent Intermediate State of the HIV 1 Envelope Glycoproteins
... Our report provides new insights into the relationship between the Env conformational landscape, virus entry requirements, and HIV-1 susceptibility to inhibitors and antibodies. Changes in spe- cific gp120 V1/V2 ...
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Hypothesis of snake and insect venoms against Human Immunodeficiency Virus: a review
... enzymes. HIV infects a CD4 cell of a person's body and then it copies its own genetic code into the cell's ...new HIV genetic material and proteins. These proteins are degraded by HIV protease enzyme ...
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