HIV integrase
HIV integrase and the swan song of the CD4 T cells?
... these HIV-infected patients having CD4 cell counts up to 600 per mm 3 ...of HIV integrase, decreased the occurrence of cell death not only in T/B lymphoblastoid cell line CEMX174, but also in primary ...
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Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors
... 40-HIV integrase mutant chimera as a novel tool to classify the mechanism of action of potential integrase ...of integrase inhibitor ...
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HIV Integrase Inhibitors Block Replication of Alpha , Beta , and Gammaherpesviruses
... the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been devel- oped that bind to this site and inhibit its ...that HIV integrase inhibitors might also inhibit ...
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Noncovalent SUMO interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
... Interestingly, IN was shown to interact with SUMO1 and SUMO2 in a yeast two-hybrid system and a coim- munoprecipitation (co-IP) assay [13]. Thus, the intri- guing questions to ask are whether IN bears SIMs and how the IN ...
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Novel therapeutic strategies targeting HIV integrase
... for HIV, selectivity (such as for IN) that is distinct from effects on other targets (such as RT and protease) needs to be ...as integrase strand transfer inhibitors ...
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Analysis of Natural Sequence Variation and Covariation in Human Immunodeficiency Virus Type 1 Integrase
... the HIV integrase coding region showed signs of convergence due to the repeated observation of pairs of covarying amino acids within separate branches of each subtype ...
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Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication
... to HIV-1 PIC nuclear import and replication. However, how HIV interacts with different cellular machineries to ensure efficient nuclear import of its preintegration complex in dividing and nondividing cells ...
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Raltegravir in the management of HIV-infected patients
... of HIV-1 proviral DNA into the host cell ...the HIV-1 viral RNA genome is associated with a “preintegration complex”, containing both cellular and viral proteins, including ...DNA. HIV ...
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Histone deacetylase 1 interacts with HIV 1 Integrase and modulates viral replication
... the HIV integrase, we have developed a purification method based on the use of streptavidin magnetic beads coupled to the integrase and the viral DNA of ...that HIV-1 integrase binds ...
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CURRENT STATUS OF HIV-1 INTEGRASE INHIBITORS
... on HIV integrase catalysis it is difficult to find the exact pharmacophore for its ...on integrase and reverse transcriptase (RT) it would be possible to observe anti-integrase ...of ...
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Role of raltegravir in the management of HIV-1 infection
... against HIV has ushered in a new age of optimism in the management of patients infected with the ...the HIV integrase enzyme, which is responsible for integration of virally encoded DNA into the host ...
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Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells
... eccentric HIV-1 particles carrying a minimal viral genome (47) or full-length viral genomes (NL4-3) and a fixed amount of WT green fluorescent protein (GFP) reporter ...
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Inhibition of HIV 1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
... of HIV-1 to infect cell-cycle arrested cells has been ascribed to the ability of its pre-integration complex (PIC) [6,7] to translocate across the nuclear envelope via the NPC ...and integrase (IN) ...the ...
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Mutations Located outside the Integrase Gene Can Confer Resistance to HIV 1 Integrase Strand Transfer Inhibitors
... Alamos HIV-1 database, representing a total of 23,874 sequences, showed that the motif was highly conserved, with each G considered individually showing variability on the order of ...
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Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation
... extend these observations (Fig. 3B and D). Their compactness and density distinguish condensates from the other material that typ- ically occupies the space between the core and the viral envelope, which we take to be ...
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<p>Dolutegravir And Lamivudine Combination For The Treatment Of HIV-1 Infection</p>
... against HIV-1 and HIV-2 ...reduces HIV replication and overall viral fi tness; hence good clinical out- comes may still be observed for patients with 3TC-resistant strains of HIV-1 that ...
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HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
... reducing HIV-1 susceptibility in combination with thymidine analog mutations (TAMs), most likely by slowing the activity of RNase H and thereby allowing more time for TAM-mediated primer unblock- ing ...
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Raltegravir in treatment naïve patients
... mutations. HIV genotyping before initi- ation of antiretroviral treatment is recommended by international guidelines, nevertheless there are clinical settings in which this guideline is not fully implement- ...
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Unintegrated HIV 1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy treated patients
... a HIV-1 replication, which could be prevented by the use of an HIV-1 integrase ...rescuable HIV- 1-antigens production from unintegrated HIV-1 genomes declined over ...unintegrated ...
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Synthesis, antiinflammatory and HIV-1 integrase inhibitory activities of 1,2-bis[5-thiazolyl]ethane-1,2-dione derivatives
... of proviral DNA, resulting from the reverse transcription of viral RNA, into the host genome. This is achieved in a stepwise fashion by endonucleolytic processing of proviral DNA within a cytoplasmic preintegration ...
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