HIV persistence
Digital PCR as a tool to measure HIV persistence
... suppress HIV replication in infected patients, the virus persists and rebounds when treatment is ...Traditionally, HIV persistence studies have used real-time PCR (qPCR) to measure the viral ...
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In vivo platforms for analysis of HIV persistence and eradication
... viral persistence, because infected cells located within these tissues may be extremely difficult to eliminate due to a lack of drug penetrance (16, ...the HIV reservoir in human ...to HIV ...
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ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions
... mice, fixed in 4% paraformaldehyde overnight at 4°C, embedded in paraffin, cut into 5-μm sections, and mounted onto poly-l-lysine– coated glass slides. Following paraffin removal, antigen retrieval (Diva Decloaker, ...
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Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise
... for HIV DNA and complex co-culture assays on several lev- ...than HIV DNA quantification assays by PCR, but much less cumbersome than ...replication-competent HIV such as QVOA present other ...
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Total HIV DNA: a global marker of HIV persistence
... The quantitative real-time PCR offers a number of technical advantages, making the total HIV DNA the most widely used marker for exploring HIV reservoirs. There are multiple reasons for this situation: the ...
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Brief_Report__No_Evidence_for_an_Association.15.pdf
... of HIV persistence or immune activation/ in fl ...in HIV-1 reservoir reflected by lower measured levels of viral ...decreased HIV reservoir size accounts for our reported statin association with ...
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jiy011.pdf
... (HIV) persistence are ...of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-as- sociated-DNA, cell-associated RNA) or soluble markers of in- ...impact HIV ...
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PubMedCentral-PMC5322797.pdf
... the HIV long terminal repeat (LTR) by the activity of histone deacetylases and other regulatory proteins and by the absence of host factors needed to support viral transcription, including nuclear factor kappa B ...
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127413.2-20190723193456-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
... evaluating HIV in the CSF to inform cure research, there are gaps in our knowledge regard- ing whether HIV persistence is associated with ...CNS HIV infection can result in impaired ...
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Persistent HIV infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance
... evaluating HIV in the CSF to inform cure research, there are gaps in our knowledge regard- ing whether HIV persistence is associated with ...CNS HIV infection can result in impaired ...
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Cellular mechanisms underlying HIV-1-associated dementia
... f HIV-1 infect microglia in vitro (Sheih et ...mediate HIV-1 entry into neurones, the presence o f a receptor primarily intended to attract lymphocytes to sites o f inflammation on the surface o f neuronal ...
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Whole-Cell Pertussis Vaccine Induces Low Antibody Levels in Human Immunodeficiency Virus-Infected Children Living in Sub-Saharan Africa
... for HIV-infected infants should considerably prolong their life ...the persistence of antibodies to the wP vaccine in HIV-infected and uninfected children who had previously received this vaccine in ...
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Hepatitis B Co - Infection in HIV AIDS Patients in Woldia, Ethiopia
... agents. HIV infected individuals are more susceptible to hepatitis B viral infection as their disease progresses into ...in HIV infected ...among HIV positive patients in Woldia General Hospital, ...
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The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection
... and HIV-1 particles within infected macrophages are protected from neutralization antibodies [44-46] and can be trans- mitted efficiently to T cells [47,48], we compared infection of PBMCs and MDMs mediated by ...
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Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy
... the persistence of latently infected cells may reflect the long decay half-life of this cellular reservoir or ongoing viral replication at low levels with continuous replenishment of the population or ...of ...
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Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture
... The persistence of anti-HIV activity of an inhibitor presents a new way of looking at the pharmacodynamic property of an inhibitor in vitro that may predict its in vivo ...two-component persistence ...
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Effect of social relationships on antiretroviral medication adherence for people living with HIV and substance use disorders and transitioning from prison
... to HIV care are exacerbated by the context of New Haven being the 7 th poorest city for its size and high socio-economic dis- parities with one third of inhabitants living below the 2011 Federal poverty level ...
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The role of HIV integration in viral persistence: no more whistling past the proviral graveyard
... of HIV-infected cells was reported in studies of cell-associated HIV DNA from indi- viduals undergoing long-term ...derived HIV can be complex, as many proviral sequences are ...of HIV ...
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Novel remote electronic medication supply model for opioid-dependent outpatients with polypharmacy––first long-term case study
... Case presentation: We report the first long-term experiences with a novel remote electronic medication supply model for two opioid-dependent patients with HIV. John (beginning dementia, 52 years, 6 tablets daily ...
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Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta.
... control of the productive and persistent course of HIV-1 in human fetal glial cells 29 and testing other known cytokines for their abilities to release persistence from astrocyte culture[r] ...
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