HLA B27
HLA-B27 ASSOCIATED UVEITIS
... to HLA-B27 negative and to have no associated ...of HLA-B27 positivity and sacroiliac involvement (although uveitis with UC and HLA-B27 negativity is more common than with the ...
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Use of HLA B27 tetramers to identify low frequency antigen specific T cells in Chlamydia triggered reactive arthritis
... with HLA-A2/EBV peptide- specific and HLA-B27/EBV peptide-specific tetramers To determine optimal conditions for the refolding proce- dure of soluble HLA-B27 monomers we used ...
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ERAP1 genetic variations associated with HLA B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis
... were HLA-B27 carriers and 393 patients demonstrated syndesmophyte formation (group 2 with mSASSS <24 plus group 3 with mSASSS >24) based on spine radio- graph ...for HLA-B27 (380 out of ...
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Polymorphisms in the F pocket of HLA B27 subtypes strongly affect assembly, chaperone interactions and heavy chain misfolding
... Two HLA-B27 subtypes, HLA-B*27:06 and 09 exhibit no association with AS (12-14), though some contradictory data has previously been reported for HLA-B*27:09 (15, ...subtype HLA-B*27:05. ...
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HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps
... or HLA-B27 antigen plus two SpA features (clinical arm), in a patient with chronic low back pain and age at onset of less than 45 years ...Therefore, HLA-B27 plays a central role in SpA ...
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Autoantibodies to the HLA B27 sequence cross react with the hypothetical peptide from the arthritis associated Shigella plasmid
... nitrogenase peptide. Leucine appeared to be a critical residue for this cross-reaction. AS patients' anti-B27 peptide antibodies reacted with HLA-B27 transfected L cells. These results may suggest ...
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Mathavan, Ernest (2011): Expression und Epigenetik bei HLA B27 assoziierter Arthritis. Dissertation, LMU München: Medizinische Fakultät
... von HLA-B27 ...mangelnden HLA-B27 Molekül Expression kein anerkanntes Phänomen der SpA ...zu HLA-B27 durch das vorgelegte Experiment nachgewiesen ...
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HLA B27–mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis
... ic HLA-B27–mediated spliced X-box–binding protein 1 (sXBP1)/ retinoic acid receptor-β (RARB)/tissue-nonspecific alkaline phos- phatase (TNAP) pathway contributed to the syndesmophyte for- mation of ...
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HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia
... common HLA B27 allele types are B*2705 (in representatives of Caucasian race and American Indians), B*2704 (Asiatic), and HLA-B*2702 (Mediterranean population) ...other HLA B27 allele ...
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HLA B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2 microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m
... bovine serum albumin and 0.1% sodium azide) (Becton Dickinson & Co., San Jose, CA), cells were incubated with fluorescence-labeled secondary antibody (IgG goat anti–mouse Fab 9 2; Accurate Chemical and Scientific ...
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Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA B27 transgenic rat model of spondyloarthritis
... that HLA-B27/hβ2m-expressing myeloid-derived cell was critical to trigger inflammatory disorder in B27-Tg rat, justified to explore the potential implication of cDCs in the triggering of this SpA ...
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CD8+ T cell autoreactivity to an HLA B27–restricted self epitope correlates with ankylosing spondylitis
... self-derived HLA- B27–specific peptides, like H2 and p53 266-274, do not appear to stimulate any relevant reactivity in both ...that B27-related arthritis requires the binding of a specific peptide ...
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Loss of viral fitness and cross recognition by CD8+ T cells limit HCV escape from a protective HLA B27 restricted human immune response
... Finally, we also introduced substitutions affecting the C-ter- minal HLA-B27–binding anchor. For these experiments, the WT phenylalanine residue was replaced by either alanine (B5) or gly- cine (B6) to ...
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Loss of viral fitness and cross recognition by CD8+ T cells limit HCV escape from a protective HLA B27–restricted human immune response
... for subject 6, the HLA-B27 subtype could not be defined) with resolved HCV infection were included. Subjects 1, 4, and 5 were infected by a con- taminated Rhesus factor D–specific Ig preparation in 1977 and ...
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Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid
... the HLA-B27 molecule, we compared the HLA binding capac- ities of KK10 epitope variants to that of the WT ...an HLA-B27-restricted influenza nucleo- protein epitope (SRYWAIRTR; ...
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Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication
... with HLA-B27, which has been linked to the immunodominant CTL response targeting the KK10 epitope, is maintained in vivo as a result of the difficulty of mutating this highly conserved region of the ...
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Sponyloarthritis features forecasting the presence of HLA B27 or sacroiliitis on magnetic resonance imaging in patients with suspected axial spondyloarthritis: results from a cross sectional study in the ESPeranza Cohort
... Furthermore, in patients with suspected axSpA the starting point of the disease is usually the presence of CBP. However, CBP is one of the most prevalent symp- toms in the general population and therefore it is essential ...
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Endoplasmic Reticulum Degradation Enhancing α Mannosidase like Protein 1 Targets Misfolded HLA B27 Dimers for Endoplasmic Reticulum Associated Degradation
... type HLA-B*27:05 or with similarly tagged misfolding HLA-B27 molecules which have had the conserved structural cysteines of the α2 domain mutated to serines at position 101 (C101S) or 164 ...for ...
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Expression of arthritis causing HLA B27 on Hela cells promotes induction of c fos in response to in vitro invasion by Salmonella typhimurium
... of HLA-B27 in the initiation of the earliest host activi- ties after exposure to Salmonella , namely activation of the immediate early genes in the epithelial ...transfected HLA-B27 gene, but ...
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Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA B27/human beta2 microglobulin transgenic rats
... Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal lu- minal bacteria and several groups of selected ...
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