HLA-C
HLA C increases HIV 1 infectivity and is associated with gp120
... unrelated, HLA-C insensitive gp120/gp41s identified, NDK (clade D) and J500 (clade B), with the sequences of the HLA-C sensitive Envs, revealed 3 identical aminoacid substitu- tions in the V3 ...
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Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of the HLA-C Gene and Surface HLA-C Expression
... 35 C allele is that it is associated with higher cell surface levels of HLA-C protein than those with the nonprotective T allele (17, 18, 30, 48, ...with HLA-E ...for HLA-C, ...
8
HLA C and HIV 1: friends or foes?
... protein HLA-C plays a crucial role as a molecule capable of sending inhibitory signals to both natural killer (NK) cells and cytotoxic T lymphocytes (CTL) via binding to killer cell Ig-like receptors ...
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Spontaneous control of HIV 1 viremia in a subject with protective HLA B plus HLA C alleles and HLA C associated single nucleotide polymorphisms
... including HLA alleles (B*14, B*57, C*06 and C*08.02) and HLA-C single nucleotide polymorphisms (SNPs, rs9264942 C/C and rs67384697 del/del), that have been previously ...
9
Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes
... morphic HLA encoded alpha chain and a beta-2- microglobulin (B2M) protein that acts as a stabilizing ...to HLA-A, HLA-B, and HLA-C, B2M binds to other immune proteins including CD1, ...
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Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity
... unstable HLA-C allotypes were analyzed for HLA-C surface expression with either the DT9 (which recognizes HLA-C heterotrimers) or the L31 (which recognizes HLA-C ...
19
An HLA C amino acid variant in addition to HLA B*27 confers risk for ankylosing spondylitis in the Korean population
... correlated HLA-A markers (e.g., HLA-A*02:01; OR = ...of HLA-B ...for HLA-B*27 (OR = ...an HLA-C amino-acid variant with a second effect, but the uncondi- tioned effect of ...
6
HLA C locus alleles may modulate the clinical expression of psoriatic arthritis
... two HLA-Cw alleles under-represented in PsA patients in comparison with ...them, HLA- Cw*0701, has been found as part of one of the ancestral hap- lotypes associated with psoriasis (HLA-Cw7-B8- ...
5
Counteraction of HLA-C-Mediated Immune Control of HIV-1 by Nef
... of HLA-C expression may facilitate control of HIV irrespectively of the ⫺ 35 ...antagonize HLA-C-me- diated immune control directly, it may achieve this (in some individuals) by indirect ...
12
Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk
... decreased risks associated with allele combinations containing only class I alleles, such as A*0201-B*1501 (OR 0.4, 95% CI0.2-0.7) and B*0801-Cw*0701 (OR 0.7, 95% CI 0.5-0.9). In this study, B*4402 was found to be a ...
28
HLA Class I-Mediated HIV-1 Control in Vietnamese Infected with HIV-1 Subtype A/E
... that HLA-B*52:01-C*12:02 is a protective haplotype in Japa- nese individuals infected with HIV-1 subtype B ...of HLA-B52:01-restricted CTLs was associated with low pVL and high CD4 T cell counts, ...
11
Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans
... these HLA- B–HLA-C haplotype combinations may have exerted particu- larly strong joint effects on the usual class I-mediated CTL ...that HLA-C-restricted CTL re- sponses may influence ...
5
Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses
... from HLA-C2/C2 subjects were stained with antibodies to ...of HLA-C–inhibited NK cells in PBMCs. The HLA-C– inhibited NK cell subset consists of KIR2DL3 + NK cells in HLA-C1 ...
11
Signatures of Demographic History and Natural Selection in the Human Major Histocompatibility Complex Loci
... (a) HLA-A, HLA-B, and HLA-C or (b) DRB1 and DQB1 (a subset of populations additionally had genotyping for DPB1); and the HLA genotyping was carried out at high molecular resolu- ...
22
Monalizumab: inhibiting the novel immune checkpoint NKG2A
... of HLA-C on the surface of tumor ...higher HLA-E expression may be preferred for exploiting adaptive NK cell functions for ...of HLA-E elicits an activating ...of HLA-E may experience ...
8
Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection
... of HLA-DQB1*03 is exclusive to non-Caucasian Americans in Baltimore and Chicago (see Table ...in HLA associations with HCV ...[5,7,22-24]. HLA-class I anti- gens, together with viral peptides, ...
8
HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients
... Nonthaburi, Thailand. The targeted study population comprised 672 HIV-1/AIDS patients and the study period ran from March 2007 to March 2008. Patients who devel- oped apparent skin rash anywhere on the body after NVP ...
7
HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs
... is HLA-C downregulation relatively common among primary HIV-1 variants if it leads to NK recognition? The balance between evading NK and CD8 T cells may drive this ...that HLA-C downregulation ...
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CD8 T-Cell Recognition of Multiple Epitopes within Specific Gag Regions Is Associated with Maintenance of a Low Steady-State Viremia in Human Immunodeficiency Virus Type 1-Seropositive Patients
... One example of a very strong, yet potentially ineffective, CD8 T-cell response during chronic HIV infection is the tar- geting of the Gag epitope TL9. This epitope is presented by the class I alleles B0702, B4201, and ...
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