HMG COA
56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... There are many reports, on the hypocholesterolemic potency of herbal drugs. Epidemiologic studies have shown a correlation between an increased consumption of phenolic antioxidants and a reduced risk of CVD which is ...
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Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
... Abstract: Brachytherapy and external beam radiotherapy are effective and commonly used treatment modalities in men with localized prostate cancer. In this review, we explore the role of radiation therapy in the curative ...
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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... Since one of the primary factors that cause drug attrition is the poor ADMET properties, the 278 compounds with higher docking scores were evaluated in silico using the DSSTox and the ADMET prediction tools of DS 3.5. ...
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CHRONOPHARMACOTHERAPEUTIC RELEASE OF HMG COA REDUCTASE INHIBITOR: USING NOVEL COATING TECHNIQUE
... words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. [2] There are many conditions that demand ...
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3-HMG-CoA Reductase Inhibitors and Inflammation: Underlying Mechanisms and Role in Atherosclerosis
... The 3-HMG-CoA reductase inhibitors, referred to as statins, are one of the most potent lipid lowering drugs. They significantly reduce incidence of cardiovascular mortality and morbidity. Data from clinical ...
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Aplexone targets the HMG CoA reductase pathway and differentially regulates arteriovenous angiogenesis
... 3-hydroxy-3-methylglutaryl- CoA synthase; HMGCR, HMG CoA reductase; FDPS, farnesyl diphosphate synthetase; Cyp51, lanosterol 14 -demethylase; SC4MOL, sterol-C4- methyl oxidase-like; DHCR7, ...
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Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... This paper deals to design a potent drugs for cardiovascular disorders in which HMG Co A is the main target. Objective of our study is to optimize the activity of statin group of drugs against HMG - ...
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Original Article Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase
... and HMG-CoA reductase in these MFH cases and relevant mesenchymal ...as HMG-CoA reductase expression, was significantly stronger in MFH cases than other non-MFH ...and HMG-CoA ...
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HMG-CoA Reductase Inhibitory Activity of Gnetum gnemon Seed Extract and Identification of Potential Inhibitors for Lowering Cholesterol Level
... through HMG-CoA reductase inhibitory ...using HMG-CoA Reductase assay kit, to analyze the inhibitory ...against HMG-CoA reductase with IC 50 value is ...
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HMG CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
... Statins inhibit the activity of HMG-CoA reductase, which catalyzes the synthesis of mevalonate, a rate-lim- iting step in cholesterol biosynthesis. The clinical appli- cation of statins has already led to ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... specifically HMG-CoA reductase inhibitors, has been reported to have immunosuppressive effects in a study of heart transplant recipients ...of HMG-CoA reductase inhibitor, mostly used as ...
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Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG CoA Reductase—A Review
... The knowledge emerging from the earlier studies re- viewed above enables the characterization of some plant biologically active compounds which can inhibit the syn- thesis and enhance the degradation of ...
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The effect of aerobic training and consumption of L-carnitine supplements on Gen expression of HMG-CoA reductase and LDL receptor in the liver of male Wistar rats Injected by Boldenone
... on HMG-CoA reductase and LDL receptor in the liver of male Wistar rats toxicated by ...isolated. HMG-CoA reductase and LDL receptor expression in the samples were measured by Real Time PCR and ...
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Pleiotropic effects of the HMG-CoA reductase inhibitors
... Abstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary ...
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HMG-CoA reductase inhibitor lovastatin upregulates plasminogen activator production through RhoA-signaling in peritoneal cell line Met5A
... Abstract This study was conducted to determine if hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor statin, known to protect postoperative adhesion in animal model, affect the expressing ...
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7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... of HMG-CoA reductase enzyme catabolism. Stability of HMG-CoA reductase was stud- ied in an in vitro system developed by Simoni and col- leagues, which employs a fusion gene (HMGal) consist- ...
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Synthesis of HMG-CoA Reductase Inhibitor Lanost-8-en-3β-ol-7, 11-dione through Oxidation of 3β-acetoxylanost-8-en-7, 11-dione with Pyridinium Chlorochromate
... Allylic oxidation of 3B-acetoxylanost-8-ene was accomplished with pyridinium chlorochromate (PCC) and chromium trioxide/ acetic acid to form 3B- acetoxylanost-8-en-7,11-dione, which was later reduced to ...
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An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin
... way. HMG-CoA reductase inhibitors are better antagonists for blocking the biosynthesis pathway of ...(or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used as ...
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The Influence of Sam Chil Geun (Panax Notoginseng) on the Serum Lipid Levels and Inflammations of Rats with Hyperlipidemia Induced by Poloxamer 407
... Lovastatin and pravastatin inhibited cholesterol synthesis by acting as HMG-CoA reductase inhibitors.25 In the present study, the Sam-Chil-Geun extract was administered to the rats with [r] ...
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Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli
... supply by overexpression or deletion of upstream path- way genes, and altering global metabolic network by rational strategies or random mutagenesis [10–12]. MEP pathway has been engineered to increase IPP and DMAPP in ...
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