HMG-CoA Reductase
Aplexone targets the HMG CoA reductase pathway and differentially regulates arteriovenous angiogenesis
... 3-hydroxy-3-methylglutaryl- CoA synthase; HMGCR, HMG CoA reductase; FDPS, farnesyl diphosphate synthetase; Cyp51, lanosterol 14 -demethylase; SC4MOL, sterol-C4- methyl oxidase-like; DHCR7, ...
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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... nutrition improvement, the contribution of complementary medicines such as dairy products still deserves more investi- gations. In the present study, we have shown that combining high-throughput virtual screening and in ...
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An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin
... way. HMG-CoA reductase inhibitors are better antagonists for blocking the biosynthesis pathway of ...(or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used ...
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7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... of HMG-CoA reductase enzyme catabolism. Stability of HMG-CoA reductase was stud- ied in an in vitro system developed by Simoni and col- leagues, which employs a fusion gene ...
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56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... A reductase has greater significance in cholesterol metabolism and, thus, has various health ...the HMG-CoA also blocks Coenzyme Q required for energy production and, thus, impairing cardiac and ...
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The effect of aerobic training and consumption of L-carnitine supplements on Gen expression of HMG-CoA reductase and LDL receptor in the liver of male Wistar rats Injected by Boldenone
... (HMG- COA) to Mevalonate is a catalyzed reaction by HMG-COA ...HMGCoA reductase is an enzyme that converts acetate into cholesterol or in other words, it controls the biosynthesis of ...
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Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... of HMG-Co A reductase with known crystal structure of four chains has been identified and down loaded from the National Centre for Biotechnology and the detail pertaining to the molecular properties of ...
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Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
... Despite advances in technique and technology in both brachytherapy and EBRT, there continues to be a chal- lenge to provide excellent rates of disease control while keeping the risk of toxicity very low. There is growing ...
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CHRONOPHARMACOTHERAPEUTIC RELEASE OF HMG COA REDUCTASE INHIBITOR: USING NOVEL COATING TECHNIQUE
... words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. [2] There are many conditions that demand ...
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3-HMG-CoA Reductase Inhibitors and Inflammation: Underlying Mechanisms and Role in Atherosclerosis
... The 3-HMG-CoA reductase inhibitors, referred to as statins, are one of the most potent lipid lowering drugs. They significantly reduce incidence of cardiovascular mortality and morbidity. Data from ...
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Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG CoA Reductase—A Review
... isoprenoids. HMG-CoA reduc- tase is a rate-determining enzyme in mevalonate pathway, producing intermediates such as farnesyl and geranylgeranyl pyrophosphates, which lead to by-products such as ...of ...
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HMG CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
... Statins inhibit the activity of HMG-CoA reductase, which catalyzes the synthesis of mevalonate, a rate-lim- iting step in cholesterol biosynthesis. The clinical appli- cation of statins has already ...
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Pleiotropic effects of the HMG-CoA reductase inhibitors
... Abstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These ...
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HMG-CoA reductase inhibitor lovastatin upregulates plasminogen activator production through RhoA-signaling in peritoneal cell line Met5A
... (HMG-CoA) reductase inhibitor statin, known to protect postoperative adhesion in animal model, affect the expressing tissue-type plasminogen activator (tPA) in peritoneal cells in ...of ...
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Synthesis of HMG-CoA Reductase Inhibitor Lanost-8-en-3β-ol-7, 11-dione through Oxidation of 3β-acetoxylanost-8-en-7, 11-dione with Pyridinium Chlorochromate
... Allylic oxidation of 3B-acetoxylanost-8-ene was accomplished with pyridinium chlorochromate (PCC) and chromium trioxide/ acetic acid to form 3B- acetoxylanost-8-en-7,11-dione, which was later reduced to ...
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Original Article Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase
... of HMG-CoA reductase, have been proved as chemopreventive drugs for variable ...of HMG-CoA reductase in most of the breast cancer cases, which was associated with an improved ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... specifically HMG-CoA reductase inhibitors, has been reported to have immunosuppressive effects in a study of heart transplant recipients ...of HMG-CoA reductase inhibitor, mostly ...
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Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli
... To balance MVA pathway flux, it is necessary to express the HMG-CoA reductase and MK at a higher level to decrease accumulation of HMG-CoA, and to eliminate the rate-limiting step. In ...
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ANTI INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON
... conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes ...inhibiting HMG CoA ...natural HMG CoA reductase ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Decreased enzyme catalytic efficiency in familial hypercholesterolemia
... measured HMG CoA reductase protein concentration and microsomal enzyme activity in freshly isolated mononuclear leukocytes from normal individuals and patients with heterozygous or homozygous ...
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