HMG-CoA reductase enzyme
Chromatographic and spectrophotometric method for estimation of statin class drugs in bulk and in different dosage forms
... blocking HMG-CoA reductase enzyme, which is useful in catalyzing the rate-limiting step in cholesterol ...inhibiting HMG-CoA reductase with respect to the binding of ...
7
7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... Thus, the 7DHC that accumulates in patients with SLOS accelerates proteolysis of HMG-CoA reductase enzyme protein, thereby depriving the developing organ- ism of needed sterols. Although this ...
12
Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... of HMG-Co A reductase with known crystal structure of four chains has been identified and down loaded from the National Centre for Biotechnology and the detail pertaining to the molecular properties of ...
9
ANTI INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON
... Solvent-solvent Partition: The process was performed according to the protocol of Rahman et al., 30 with a few modifications. Three different solvents- hexane, ethyl acetate, and chloroform were used for the process. ...
7
Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells
... inhibit HMG-CoA reductase activity in other non-hepatic human cells is considered to vary with their lipophilicity, simvastatin being 5- to 40-fold more potent than ator- vastatin and ~600-fold more ...
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HMG-CoA reductase inhibitor lovastatin upregulates plasminogen activator production through RhoA-signaling in peritoneal cell line Met5A
... (HMG-CoA) reductase inhibitor statin, known to protect postoperative adhesion in animal model, affect the expressing tissue-type plasminogen activator (tPA) in peritoneal cells in ...and ...
5
Synthesis of HMG-CoA Reductase Inhibitor Lanost-8-en-3β-ol-7, 11-dione through Oxidation of 3β-acetoxylanost-8-en-7, 11-dione with Pyridinium Chlorochromate
... The present work concerns the synthesis of lanost-8-en-3B-ol-7,11-dione, a prominent autoxidation (air oxidation) product of naturally occurring 24,25- dihydrolanosterol, and its evaluation as an inhibitor of HMGR ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... HMG-CoA reductase inhibitors (statins) are commonly used in medicine to control blood lipid ...(HMG-CoA) reductase [5]. The role of the regulatory enzyme ...
5
Journal of Applied Pharmaceutical Science
... Interestingly, medicinal plants including garlic have been used for centuries due to its versatile health benefits, including but not limited to, its cancer-protective and cardiovascular-protective effects, but the ...
6
In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Studies in normal subjects
... in enzyme activity within 90 min of treatment. Finally, reductase activity was inhibited by dichloroacetate, a compound known to lower plasma cholesterol in man and inhibit the human leukocyte enzyme ...
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Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG CoA Reductase—A Review
... isoprenoids. HMG-CoA reduc- tase is a rate-determining enzyme in mevalonate pathway, producing intermediates such as farnesyl and geranylgeranyl pyrophosphates, which lead to by-products such as ...
11
An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin
... way. HMG-CoA reductase inhibitors are better antagonists for blocking the biosynthesis pathway of ...(or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used ...
6
56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... of HMG-CoA reductase (vital enzyme in cholesterol biosynthesis) as the drugs (statins), used in the management of hypercholesterolemia, are associated with side ...inhibit ...
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A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis
... microsomal HMG-CoA reductase (rate- control controlling enzyme for cholesterol biosynthesis) activity was sevenfold higher ...microsomal enzyme protein mass was eightfold larger ...
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The mechanism of dietary cholesterol effects on lipids metabolism in rats
... of HMG-CoA reductase, the key enzyme of cholesterol synthesis, suppressed significantly in the cholesterol-fed rats as compared with the control rats, which suggested that the hepatic ...
6
Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
... Statin medications are first-line pharmacotherapy for the treatment of hypercholesterolemia and prevention of cardiovascular disease, and an estimated 25.2 million Americans are currently receiving statin therapy ...
102
Unexpected inhibition of cholesterol 7 alpha hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits
... hydroxylase and hepatic LDL receptor function and mRNA levels in 23 New Zealand White (NZW) and 17 Watanabe heritable hyperlipidemic (WHHL) rabbits. Plasma cholesterol concentrations were 9.9 times greater in WHHL than ...
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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human ...
12
Pleiotropic effects of the HMG-CoA reductase inhibitors
... The pleiotropic effects of statins are attributed to several processes resulting from the inhibition of HMG-CoA reductase. The main effect of statins is the inhibition of cholesterol and isoprenoid ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Decreased enzyme catalytic efficiency in familial hypercholesterolemia
... to enzyme phosphorylation or thiol-disulfide ...increased reductase activity, the degree of which was directly proportional to the LDL-receptor status of the ...Decreased HMG CoA ...
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