HMGA2 Protein
Overexpression of HMGA2 promotes tongue cancer metastasis through EMT pathway
... between HMGA2 protein expression level and the overall survival time in tongue cancer ...with HMGA2 protein expression, on patient survival, were examined with Kaplan–Meier analysis and the ...
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E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression
... by HMGA2: the E2F1 protein is not displaced from the pRB complex, but an increased acetylation that is dependent on the removal of HDAC1 from pRB takes ...E2F1 protein in pituitary adenomas when the ...
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Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth
... revealed HMGA2 as one of the top significantly enriched oncogenes in MPNSTs compared with that in normal nerves or NF1 neurofibromas ...whether HMGA2 is overexpressed in fresh tissue ...that HMGA2 ...
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Expression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder
... The HMGA2 protein was found in the late 1980s, as one of the high mobility protein family members, encoded by the HMGA2 gene which is located on chromosome 12 q14, 15, and has a molecular ...
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Derepression of HMGA2 Gene Expression in Retinoblastoma Is Associated with Cell Proliferation
... the HMGA2 coding sequence in an antisense orientation (Ad-A2as), and its parental vector (Ad-GFP), were prepared by Alfredo Fusco using the described method ...antisense HMGA2 RNA expression in suppressing ...
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<p>Impact of high-mobility-group A2 overexpression on epithelial-mesenchymal transition in pancreatic cancer</p>
... evaluated HMGA2 overexpression for its effects on pancreatic cancer ...Methods: HMGA2 protein levels were immunohistochemically assessed in human PC tissue specimens and evaluated for associations ...
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Let 7a inhibits migration, invasion and epithelial mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma
... of HMGA2 were predicted (Figure ...targets HMGA2. We found that co-transfection of let-7a mimics and pLUC- HMGA2-wt significantly decreased the luciferase activity in CNE-2 and 5-8F cells as compared ...
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Gene Expression Profiling Identified High- mobility Group AT-hook 2 (HMGA2) as Being Frequently Upregulated in Esophageal Squamous Cell Carcinoma
... HMGA protein family members are small nuclear ...regulation. HMGA2 expression was found to be restricted during embryogenesis, whereas it is absent or has low expression in normal adult tissues ...of ...
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HMGA2 is associated with epithelial–mesenchymal transition and can predict poor prognosis in nasopharyngeal carcinoma
... that HMGA2 protein expression corre- lated significantly with tumor N stage, TNM stage, and 2-year metastasis status (P = ...of HMGA2, E-cadherin, and vimentin, Spearman’s correlation analysis was ...
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Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p
... Methods: Microarray analysis was used to screen for differentially expressed circRNAs in NSCLC tissues. The expres- sion levels of circ_100565, microRNA-506-3p (miR-506-3p) and high mobility group AT-hook 2 ...
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Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer
... of HMGA2 protein in paraffin carcinoma sections from 44 patients out of 47 with EOC, enrolled for HMGA2 mRNA detection in the plasma, by immunohistochemistry using antibodies raised versus the ...
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Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells
... the HMGA2 expression level is significantly higher in fusion gene- negative RMS (FN-RMS) than in fusion gene-positive RMS (FP-RMS) and that strong immunohistochemical expression of HMGA2 protein is ...
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Scattered genomic amplification in dedifferentiated liposarcoma
... Background: Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations ...
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TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7- HMGA2 signaling
... and Lin28A critically differ in the C-terminal region at the protein structure level. A lysine- and serine-rich 50-amino-acid stretch makes Lin28B unique in terms of post-translational modulation compared with its ...
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Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva
... of HMGA2-related miRNAs such as miR- 30c and let-7a, and whether a correlation exists between the expression of FHIT and HMGA2, in this tumor ...as HMGA2 was highly expressed (mean fold change ...of ...
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<em>MicroRNA-150</em> suppresses triple-negative breast cancer metastasis through targeting HMGA2
... Results: We found that miR-150 was down-regulated in TNBC tumor tissues compared to corresponding adjacent, normal breast tissues, and was correlated with decreased lymph-node metastasis. Ectopic expression of miR-150 ...
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Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer
... anchored protein VAPA regulates the stability of ER tubules connected to microtubules and other membrane systems [36] and the intracellular trafficking of proteins and lipids when interacting with ...
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High expression of HMGA2 predicts poor survival in patients with clear cell renal cell carcinoma
... of HMGA2 and its relationship to the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following ...of HMGA2 was evaluated retrospectively by immunohistochemistry ...
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Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state
... and Hmga2 knockout (KO) induced pluripotent stem cells (iPSCs) were labeled with CFSE and the proliferation was evaluated based on the CFSE content by flow ...and Hmga2 KO iPSCs showing the different ...
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Weinmann, Lasse (2009): Functional characterisation of microRNA-containing Argonaute protein complexes. Dissertation, LMU München: Fakultät für Biologie
... motif protein 4 (RBM4) is essential for repression of several miRNA targets, although its interaction with Ago proteins is ...Ago protein recruitment and miRNA-guided ...
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