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HMGB1 protein

Emerging roles for HMGB1 protein in immunity, inflammation, and cancer

Emerging roles for HMGB1 protein in immunity, inflammation, and cancer

... (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein ...electrophoresis. HMGB1 was later discovered to have another ...role, HMGB1 is a proinflammatory ...

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HMGB1 Protein Binds to Influenza Virus Nucleoprotein and Promotes Viral Replication

HMGB1 Protein Binds to Influenza Virus Nucleoprotein and Promotes Viral Replication

... human protein do- mains binding influenza virus ribonucleoproteins makes use of in vitro affinity selections of human protein domains for given tar- ...host-pathogen protein- protein ...

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High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis

High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis

... box protein 1 (HMGB1) is a highly conserved protein, ubiquitously expressed in the nucleus of all vertebrate ...this protein have been well ...this protein to have extracellular ...

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HMGB1 is negatively correlated with the development of endometrial carcinoma and prevents cancer cell invasion and metastasis by inhibiting the process of epithelial-to-mesenchymal transition

HMGB1 is negatively correlated with the development of endometrial carcinoma and prevents cancer cell invasion and metastasis by inhibiting the process of epithelial-to-mesenchymal transition

... of HMGB1 protein was detected in normal endometrial stroma and the endo- metrial glandular epithelial cell nucleus (Figure 1A and ...of HMGB1 was very ...of HMGB1 was detected at very low ...

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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance

Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance

... (HMGB1) protein is an important inflammatory mediator which alters the immune system to tissue stress and ...injury. HMGB1 has been implicated in the pathogenesis of multiple inflammatory diseases ...

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High mobility group box-1 and its clinical value in breast cancer

High mobility group box-1 and its clinical value in breast cancer

... HMGB1 protein in tissues was detected using a HMGB1 immunohistochemistry kit (Beijing Bioss Biotechnology, People’s Republic of China). The protocol was performed in accordance with the ...

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Mechanistic regulation of HMGB1 function in drug-induced liver injury

Mechanistic regulation of HMGB1 function in drug-induced liver injury

... (HMGB1) protein is a ubiquitously expressed protein involved in the facilitation of gene ...extracellular HMGB1 acts as a key mediator of ...(AILI), HMGB1 is passively released from ...

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HMGB1 Promotes Prostate Cancer Development and Metastasis by Interacting with Brahma-Related Gene 1 and Activating the Akt Signaling Pathway

HMGB1 Promotes Prostate Cancer Development and Metastasis by Interacting with Brahma-Related Gene 1 and Activating the Akt Signaling Pathway

... whether HMGB1 is essential for PCa oncogenesis, we first analyzed the endogenous protein expression of HMGB1 in four tumor-derived PCa cell lines (PC-3, DU145, 22Rv1, and LNCaP) by Western ...of ...

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Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

... recombinant HMGB1 protein treatment increased CitH3 expression and NET forma- tion via TLR4/9 [9] and HMGB1 induced formation of prothrombotic NETs in deep venous thrombosis animal model ...observed ...

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Inhibition of HMGB1 Overcomes Resistance to Radiation and Chemotherapy in Nasopharyngeal Carcinoma

<p>Inhibition of HMGB1 Overcomes Resistance to Radiation and Chemotherapy in Nasopharyngeal Carcinoma</p>

... Although HMGB1 stimulating ligase IV activity in vitro has been reported28, whether HMGB1 regulates NHEJ ef fi cacy in vivo has not yet been ...of HMGB1 in NHEJ in human NPC cells, we used CRISPR/cas9 ...

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Encapsulation of pancreatic islet with HMGB1 fragment for attenuating inflammation

Encapsulation of pancreatic islet with HMGB1 fragment for attenuating inflammation

... (HMGB1) protein. It is known that this HMGB1 is a non-histone protein involved in the regulation of transcription ...The HMGB1 A box has an anti-inflammatory activity, whereas ...

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Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

... (HMGB1) protein, a highly conserved nuclear protein that functions as a chromatin-binding factor, facilitates nucleosome stabiliz- ation and regulates gene transcription ...of HMGB1 in ...

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Aspirin’s Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses

Aspirin’s Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses

... SA-binding protein. SA-binding sites on HMGB1 were identified in the HMG-box domains by nuclear magnetic resonance (NMR) spectroscopic studies and con- firmed by mutational ...Extracellular HMGB1 is ...

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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

... Measuring HMGB1 in whole-cell protein extracts showed ele- vated levels of HMGB1 protein in the spinal cord after the induction of nerve ligation (75), diabetic neuropathy (80) and bone cancer ...

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Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein

Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein

... the HMGB1 protein is a transcription factor, it binds strongly to nuclear ...canine HMGB1 neither prevents the mediated uptake of the vector in presence of a transfection reagent nor has any visible ...

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Original Article Expression of HMGB1/RAGE protein in renal carcinoma and its clinical significance

Original Article Expression of HMGB1/RAGE protein in renal carcinoma and its clinical significance

... of HMGB1 in renal cancer tissues was manifested as brown staining in the cytoplasm or nuclei (Figure 2), whereas positive RAGE protein expression was mani- fested as brown staining in the cell membrane ...

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The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

... (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory and autoimmune diseases once it is in an extracellular ...residues, HMGB1 can induce cytokine ...

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Original Article High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF- B pathways

Original Article High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF- B pathways

... ice-cold protein ex- traction buffer (Biyuntian, China) containing the protease inhibitor PMSF (Biyuntian, ...lected. Protein concentrations of cell lysates were determined by using BCA assay (Biyuntian, ...

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Original Article Blocking HMGB1 signal pathway protects early radiation-induced lung injury

Original Article Blocking HMGB1 signal pathway protects early radiation-induced lung injury

... blocking HMGB1 can reduce p65 activation and further promote the activa- tion of P50, and the increase of the ratio of the activation of P50 and p65 (Figure 5A, ...blocking HMGB1 can inhibit Th2-type ...

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HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells

HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells

... target, HMGB1 is currently related to many inflammatory diseases ...that HMGB1 is involved in inflammation and oxidative stress. Moreover, HMGB1 and ROS are associated with NF-kB pathway, when siH- ...

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