HO-1
14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling
... with HO-1 ...of HO-1 knock- down on IL-6-induced activation of STAT3 ...on HO-1-mediated STAT3 ...reporter, HO-1 and the indicated mutant plasmids for 24 h before ...
15
Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium
... approximately 1 × 10 6 HO-1MSCs or Null-MSCs in ...the HO-1 inhibitor zinc-protoporphyrin (ZnPP, Porphyrin Products, Logan, UT, USA) at a con- centration of 50 μ mol/kg/day, starting two days ...
8
Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice
... Methods: The adult healthy mice were divided into four groups, each consisting of ten subjects: mice in group Con-L VT and group Sev-L VT were ventilated with tidal volumes of 8 mL/kg for 4 hours, while those in group ...
7
The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH)
... L, 1-ethyl-3,3'-dimethylamino-propyl- carbodiimide (EDPC) and added with distilled water up to 25 μ ...cycles. HO-1 upstream primer sequences: 5 ′ -CTATCGTGCTCGCATGAAC-3 ′ , downstream primer ...
9
Original Article Heme oxygenase-1 (HO-1) alleviates vascular restenosis after balloon injury in a rabbit carotid artery model
... that HO-1 plays an important role in coronary disease [11, ...of HO-1 in inhibiting neointim- al hyperplasia, thrombosis and restenosis in balloon-injury carotid arteries of high-choles- terol ...
9
Mitochondrial quality-control dysregulation in conditional HO-1–/– mice
... stress, HO-1 eliminates cellular free heme (1), a powerful oxidant (2, 3), and produces the physiological gas carbon monoxide (CO) (4), which has potent antiinflammatory and antiapoptotic effects and ...
19
Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway
... residual HO-1 expression evident in ECs exposed to probucol-containing A-CRLPs also lends support to the notion that either the PUFAs themselves are partially responsible and/or that lipid oxidation occurs ...
15
The HO-1-expressing bone mesenchymal stem cells protects intestine from ischemia and reperfusion injury
... Methods: In this experiment, eighty adult male mice were divided into Sham, I/R, I/R + BMSC, I/R + BMSC/HO-1 groups. Mice were anesthetized and intestinal I/R model were established by temporarily occluding ...
8
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis
... of HO-1 mRNA (see Supplementary material online, Figure S2A and B) or protein (not shown) by ...PKC 1 activation or depletion on ...PKC 1 , PKC 1 (Ser729) , and HO-1 by ...
11
Associations of proteins relevant to MAPK signaling pathway (p38MAPK-1,HIF-1 and HO-1) with coronary lesion characteristics and prognosis of peri-menopausal women
... and HO-1 expressions ...not HO-1 expressions, whereas addition of p38MAPK in- hibitor abolished the increase of HO-1 expressions due to trauma haemorrhage ...
11
Melatonin protects against burn induced hepatic oxidative injury by inducing HO 1 via the Nrf2 pathway
... ROS are crucial for activation of the Nrf2 transcription factor (Chen and Niki 2006). It is suggested that mild oxidative stress and in par- ticular 4-HNE might induce nuclear translocation of Nrf2. Nrf2 protects the ...
8
Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO 1 signaling
... S-transferase, HO-1, glutamate cysteine ligase, peroxiredoxin, and GSH peroxidase, all of which contribute to cellular pro- tection by removing ROS including superoxide anions, hydrogen peroxide, and ...
10
Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... Abstract: Xylaria nigripes (XN) is a fungus used in traditional Chinese medicine and its extracts have been shown an- ti-oxidant and anti-inflammatory activities. This study was to determine the protective effect of XN ...
10
<p>HO-1 protects the nerves of rats with cerebral hemorrhage by regulating the PI3K/AKT signaling pathway</p>
... of HO-1 was examined by ...follows: HO-1, (upstream) 5 ʹ -CACGGCCATGAC- CACTTTC-3 ʹ , (downstream) 5 ʹ -GGAACAGAGTGGCTCC- AACAA-3 ʹ ; GAPDH, (upstream) 5 ʹ -CCTGCAAATGAGC- CCCAGCCTTC-3 ʹ , ...
10
<p>The Nrf2/HO-1 axis can be a prognostic factor in clear cell renal cell carcinoma</p>
... and HO-1 were consistently located in vitro and were upregulated in human ccRCC ...or HO-1 in patients tended to indicate a worse prognosis, and a high expression in ccRCC but no expression in ...
10
Original Article Asiatic acid attenuates traumatic brain injury via upregulating Nrf2 and HO-1 expression
... The brain cortex protein from injured area was extracted using a lysis buffer with protease inhibitor. Equivalent amounts of protein were loaded and separated by 8-12% SDS-PAGE gel. After electrophoresis and transferred ...
7
Increased serum HO 1 in hemophagocytic syndrome and adult onset Still's disease: use in the differential diagnosis of hyperferritinemia
... human HO-1 and glyceralde- hyde-3-phosphate dehydrogenase (GAPDH) mRNA were pur- chased from PE Applied Biosystems (Foster City, CA, ...Briefly, 1/50 amounts of of cDNA derived from 1 µg of ...
9
Induction of HO 1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis
... of HO-1 in sev- eral key organs in African children who died of clinically defined cerebral malaria or coma accompanying a bacte- rial ...of HO-1. Previous reports of HO-1 ...
13
Inhibition of Nrf2/HO 1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
... NLRP3, along with the adaptor protein apoptosis- associated speck-like protein containing a caspase recruit- ment domain (ASC), is one of the most studied inflamma- some sensors, which activates caspase-1 via the ...
13
Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury
... for HO-1 and the macrophage M1 (CXCL10, CD80, IL-1β, and MCP1) and M2 (ARG1 and CD163) polarization markers were assessed by real-time qPCR using the primers shown in Supplemental Table ...
15