homeobox transcription factor
Dysregulation of the homeobox transcription factor gene <em>HOXB13</em>: role in prostate cancer
... Thus, much current research in the field is focused on 1) identifying genetic factors that predispose to any level of disease risk; 2) understanding the tumor biology and genetic factors that contribute to tumor ...
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The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
... Macrophages are critical players in both innate and adaptive immunity. While the exogenous signaling events leading to the terminal differentiation of macrophages from monocytes have been studied extensively, the ...
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The homeobox transcription factor Barx2 regulates chondrogenesis during limb development
... and homeobox transcription factor families have been shown to have crucial ...the homeobox transcription factors that function during chondrogenesis have been the least well ...the ...
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The homeobox transcription factor Even skipped regulates acquisition of electrical properties in Drosophila neurons
... for transcription factor misexpression resulting in altered membrane ...the transcription factor HRlim have a set of common properties, including the expression of the sodium channel gene ...
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The LIM homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons
... single transcription factor Isl1 might direct the specification of distinct neuronal ...partner transcription factors. For instance, Isl1 partners with the LIM-HD factor Lhx3 in specifying ...
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Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
... Perhaps it is the background level of Msx2 interacting proteins and cofactors that determines the effect of increased levels of Msx2 in breast tumours. A link with the ER signalling pathway is also likely, as previous ...
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Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor
... Homeobox transcription factors specify body plan by regulating differentiation, proliferation, and migration at a cellular ...The homeobox transcription factor Gax is expressed in ...
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Role of microRNAs in hepatocellular carcinoma: a clinical perspective
... type homeobox transcription factor; GATA6, GATA binding protein 6; NLK, nemo-like kinase; T-ICs, tumor-initiating cells; PKM2, pyruvate kinase isozymes M1/M2; CSCs, cancer stem cells; TGF-β, ...
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Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9
... The neuropeptide hypocretin (Hcrt) is conserved among vertebrates and plays key roles in regulating sleep, metabolism, feeding, anxiety, reward and addiction (Bonnavion and de Lecea, 2010; Tsujino and Sakurai, 2009). ...
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Context specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo
... Whether Dkk1 is a direct downstream target of LHX1 has not previously been investigated. A conserved region of the mouse Dkk1 locus, referred to as H1, has been shown to be necessary for the control of Dkk1 expression ...
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Mutations in the cardiac transcription factor NKX2 5 affect diverse cardiac developmental pathways
... a homeobox transcription factor, were reported to cause secun- dum atrial septal defects and result in atrioventricular (AV) conduction block during postnatal ...this transcription ...
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Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling
... the homeobox transcription factor Pax6, which is expressed in LG epithelium (Makarenkova et ...with transcription factors that are expressed in spatially restricted patterns during ...
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Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin 1beta
... multiple transcription factors, cytokines, growth factors and their receptors, adhesion molecules, proteases, and signaling intermediates that may contribute to inflammation and cartilage destruction in ...
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Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida
... Our discovery of the PBC-homology in Archaeplastida suggests common ancestry of the heterodimerizing TALES between Metazoa and Archaeplastida. It also pre- dicted that other eukaryotic lineages might possess TALEs with ...
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Mutational analysis of the human factor IX promoter : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University
... responsible for down-regulating factor IX transcription leading to factor IX deficiency by disrupting the binding sites of transcription factors critical for factor IX gene expression.. [r] ...
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<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... reverse transcription in a 20- μ L reaction mixture using the RevertAid cDNA Synthesis Kit (Thermo Fisher Scienti fi c, USA) according to the manufacturer ’ s ...
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The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament
... The molecular mechanisms of the PDL degenerative changes in Mkx −/− mice can be explained by the function of Mkx as a transcription factor. In keeping with the findings of the PDL analysis in Mkx −/− mice, ...
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A Horizontally Acquired Transcription Factor Coordinates Salmonella Adaptations to Host Microenvironments
... isogenic transcription factor mutant grown under the respective inducing culture condition, with com- parison of SPI1-inducing culture and SPI2-inducing culture being ...
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Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.
... mimic and offers neuroprotection by inducing transcription of ARE genes.12 Nuclear factor erythroid 2–related factor 2 NRF2 is a basic leucine zipper transcription factor and is the prin[r] ...
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Curcumin targets the TFEB-lysosome pathway for induction of autophagy
... Lysosomes are acidic organelles containing a wide spectrum of hydrolytic enzyme, including proteases, peptidases, phosphatases, nucleases, glycosidases, sulfatases, and lipases designated for all types of macromolecules ...
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