Homology modeling
In-silico Homology Modeling of MMP25 involved in Asthma
... domain organization, vertebrate MMPs are divided into seven major groups: collagenases, gelatinases, stromelysines, matrilysins, Enamelysin, Metalloelastase, membrane type MMPs, and other MMP’s [17,21,22]. Matrix ...
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Structural, Functional Insights of Alsin Protein Using Homology Modeling and Docking Studies
... modeled using Schrödinger software using prime tool (Halgren, 2007) colored region in fig1 shows the position of sequence that was modeled. Since sequence similarity of alsin sequence is less that 30% for homology ...
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Homology Modeling and Conformational Epitope Prediction of Envelope Protein of Alkhumra Haemorrhagic Fever Virus
... Homology modeling was performed using two programs: M4T and Modweb which are servers for automated comparative protein structure modeling that calculate their mod- els based on the best available ...
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Homology modeling and functional annotation of bubaline pregnancy associated glycoprotein 2
... study, homology modeling and comparative gen- omics approach has been used to propose the first 3D structure and possible functions for bubaline Pregnancy associated glycoprotein ...
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A NEW TARGET FOR DIABETES: HOMOLOGY MODELING AND IDENTIFICATION OF POTENTIAL LEADS THROUGH VIRTUAL SCREENING
... CONCLUSION: In this present study, Monocarboxylate transporter 11 (MCT11) protein sequence of Homo sapiens species was selected to identify the possible lead molecules. There was no crystal structure available for MCT11 ...
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Protein 3D structure determination using homology modeling and structure analysis
... two homology modeling softwares - ESyPred3D and Swiss model, which runs on Windows operating systems, validating (ProQ), analyzing their active sites (CastP), comparing predicted structures for structural ...
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Homology Modeling of Human Alpha Glucosidase Catalytic Domains and SAR Study of Salacinol Derivatives
... Because the structures of CtMGAM and CtSI were unknown at the time we started this study, they have been predicted using the homology modeling method. The comparison of the ligand-binding pockets among the ...
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Computer-aided identification of lung cancer inhibitors through homology modeling and virtual screening
... a homology modeling ...the modeling of the target protein is carried out using different server tools, namely, BLASTp (Basic Alignment Tool program), Phyre2 (Protein Homology/analogY Rec- ...
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Homology Modeling and Docking Study on Plasmodium Protein FarensylTransferase: A Viable Target to Combat Malaria
... In summary, a 3D structure model of Pf-PFT was developed through homology modeling using X-ray structure of Rat-PFT and validated by PROCHECK and WHATIF. A flexible docking of potent Pf-PFT inhibitors i.e. ...
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HOMOLOGY MODELING AND ANALYSIS OF STRUCTURE PREDICTIONS OF KLF8 PROTEIN FROM HOMO SAPIENS
... In this study, KLF8 could even be linked with clinical data and revealed to be a significant predictor for overall and progression-free survival 11 . Only recently additional data was presented, which identified KLF8 as ...
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Homology modeling active site predictive of VP24 protein involved in Ebola Virus
... templates for homology modeling. Preferred hit contains maximum identity and lowest e-value that it was used as a template. The modeling of the 3D structure of the protein was performed by using ...
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Homology Modeling, Molecular Dynamics Simulation and Essential Dynamics on Anopheles gambiae D7r1
... Owing to the importance of the saliva protein D7r1 of Anopheles gambiae as an anti-malarial target, the present study reports the in silico structural analysis that providing insights into its structural architecture. In ...
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Z-SCORE FOR HOMOLOGY MODELING AND STRUCTURE PREDICTION OF GLOBULAR PROTEIN OF HOMOSAPIENS & PLANT
... Homology modeling predicts protein structures based on sequence homology virtue of that it is useful as comparative ...structures. Homology modeling produces an all-atom model based on ...
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Determination and validation of mTOR kinase-domain 3D structure by homology modeling
... of homology modeling to determine the catalytic site of the kinase ...template. Homology model- ing was performed using the crystallographic structure of PI3K γ (PDB ID: 3L13) which is closely ...
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HOMOLOGY MODELING OF PHASEOLIN FROM KIDNEY BEAN Phaseolus vulgaris L : ENERGY MINIMIZATION AND STRUCTURE ANALYSIS
... for homology modeling of which SWISS MODEL was used for the present work for structure ...comparative modeling of three-dimensional (3D) protein ...automated modeling starting in 1993 and is ...
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Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)
... Sequence alignments of MK5/MK2 ([PDB: 2OZA] and [PDB: 3M2W]) and MK5/MK3 ([PDB: 3FHR]), respectively, were constructed using ICM ’ s inbuilt alignment tool. These alignments were adjusted manually to match multiple ...
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Homology modeling and structural analysis of human γ glutamylcysteine ligase catalytic subunit for antitumor drug development
... Homology modeling of hGCLC was executed as pre- viously reported [27]. In brief, the hGCLC (NCBI refer- ence sequence: NP_001489.1) [28] sequences and the crystal structure coordinates of yeast GCLC (yGCLC; ...
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HOMOLOGY MODELING AND DOCKING STUDIES ON HIV REVERSE TRANSRIPTASE INHIBITORS
... of homology modeling and docking study of HIV reverse transcriptase as this work study has not been done earlier by following literature review This is an attempted with docking studies that would be ...
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IN SILICO ANALYSIS AND HOMOLOGY MODELING OF TARGET PROTEINS FOR CLOSTRIDIUM BOTULINUM
... homology modeling programs, Swiss Model and Modeller. The constructed three dimensional models were energy minimized using CHIRON by short discrete molecular dynamics (DMD) simulations. The phi and psi ...
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A bioinformatics approach for homology modeling and binding site identification of triosephosphate isomerase from Plasmodium falciparum 3D7
... Malaria is a major public health concern, and malarial parasites have developed resistance against the commonly DYDLODEOHGUXJV6RQRZDGD\VLWLVDPDMRUFRQFHUQWR¿QGRXWDQHZWDUJHWIRUGUXJWKHUDS\Plasmodium falciparum ...
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