hormone sensitive lipase
Overexpression of hormone sensitive lipase prevents triglyceride accumulation in adipocytes
... Hormone-sensitive lipase (HSL) is a cytosolic neutral lipase that hydrolyzes intracellular stores of triglycerides within adipocytes and is thought to be the rate limiting enzyme in lipolysis; ...
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Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA mediated phosphorylation of hormone sensitive lipase and ERK mediated downregulation of perilipin in 3T3 L1 adipocytes
... triglyceride lipase (ATGL) and perilipin, as well as phosphorylation of hormone-sensitive lipase (HSL), AMP-activated protein kinase (AMPK), and mitogen-activated protein kinases (MAPKs) were ...
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The substrate specificity of hormone sensitive lipase from adipose tissue of the Antarctic fish Trematomus newnesi
... Antarctic fishes of the suborder Notothenioidei characteristically possess large stores of neutral lipids that have been shown to be important both in conferring buoyant lift and as a caloric resource for energy ...
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Hormone-Sensitive Lipase Knockouts
... be hormone-sensitive lipase ...triacylglycerol lipase activity, appears to be the rate-limiting enzyme for cholesteryl ester and diacylglycerol hydrolysis in adipose tissue and is essential ...
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The Mechanism of Activation of Hormone Sensitive Lipase in Human Adipose Tissue
... nonactivated hormone-sensitive lipase to its activated form, as indicated by a decrease in the activation subsequently obtainable in fractions prepared from such hormone-treated ...of ...
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Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese
... Despite higher or identical mRNA levels in the lean and the obese subjects and in subcutaneous and omental tissues, perilipin protein expression was lower in both depots in the obese ver[r] ...
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The regulation of hormone-sensitive lipase in macrophages
... the lipase w ith its su b strate a n d associated in tracellu lar m em ...triglyceride lipase activity is observed u p o n lipolytic stim ulation in adipocytes (Egan et ...
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Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia
... kinase hormone- sensitive lipase complex with dibutyryl ...of hormone- sensitive lipase was decreased by approximately 40% in ...
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Production and Purification of a New Inhibitor of Pancreatic Lipase andHormone Sensitive Lipase from Soil Actinomycetes
... The lipase inhibitory activity was assessed using different lipases: Pancreatic lipase (PL),Hormone sensitive lipase(HSL)[13],Monoacylglycerol ...microbial lipase inhibitor and ...
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Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction
... six lipase genes listed in order of genetic association significance, as follows: LIPF gastric lipase, LIPC hepatic lipase, LIPG endothelial lipase, LIPE hormone-sensitive ...
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ISOLATION AND SCREENING OF LIPASE PRODUCING BACTERIA FROM MUNICIPAL SOLID WASTES (MSW)
... of lipase production were further screened to isolate the best possible lipase producing bacteria based on agar well diffusion or cup well ...the lipase producing isolates were inoculated separately ...
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Selecting short-statured children needing growth hormone testing: Derivation and validation of a clinical decision rule
... Shortness or decreasing growth is a frequent reason for pediatric consultations. After ruling out other causes of short stature (intestinal malabsorption, chronic liver or kidney disease, hypothyroidism, etc), the ...
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Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue
... Results: Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive[r] ...
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Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor
... To investigate the effect of anti-lipase IgY on the ab- sorption of triglyceride in the diet, we analyzed fecal lipids contents. Previous study showed that lipase inhib- ition by synthetic lipase ...
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A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries
... Lipoprotein lipase (LPL) plays a crucial role in the regulation of lipoprotein metabolism by hydrolysing the core triglycerides of circulating chylomicrons and ...
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An Approach to the Identification and Characterisation of a Psychrotrophic Lipase Producing Pseudomonas sp ADT3 from Arctic Region
... Microbial enzymes have a great number of usages in food, pharmaceutical, textile, paper, leather and other in- dustries. Their applications have been increasing rapidly. Among industrially important enzymes, hydrolases ...
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Androgen Ablation Therapy and Prostate Cancer: An Update
... Androgen ablation therapy using GnRH agonist is one of the techniques in achieving medical castration. Leuprolide and goserelin are commonly used GnRH. Its administration is usually staggered (for example, day 1-, 3-, ...
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Circulating tumor cells correlate with patterns of recurrence in patients with hormone-sensitive prostate cancer
... Abstract: The aim of this study was to evaluate the correlation between circulating tumor cells (CTCs) and patterns of recurrence in patients with hormone-sensitive prostate cancer. The study involved ...
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Cost effectiveness of docetaxel in high volume hormone sensitive metastatic prostate cancer
... Introduction: Three pivotal trials have considered the addition of docetaxel (D) chemotherapy to conventional androgen-deprivation therapy (ADT) for the treatment of metastatic hormone-sensitive pros- tate ...
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Role of N-linked glycosylation in the secretion and enzymatic properties of Rhizopus chinensis lipase expressed in Pichia pastoris
... values (Table 1). The existence of Kex2 cleavage site in the wild-type RCL resulted in the partially truncation of the prosequence in Golgi apparatus, forming r27RCLC. The higher enzyme activity of the truncated r27RCLC ...
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