Host cell immunity, microbiota, and CRC
Pathogenic functions of host microbiota
... Additional file 2: Area under the receiver-operating characteristic curve (AUC) applying generalized linear mixed-effects models for each disease based on abundances of genes encoding three pathofunctions, namely, the ...
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Colorectal carcinogenesis: an archetype of gut microbiota-host interaction
... of CRC [2]. Indeed, although CRC is predominantly a disease of later age in the West (median age at diagnosis approximately 70 years [3]), the age-specific relative risk has been increasing in younger ...
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The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity.
... how host genetics versus environment contribute to shaping the adult microbiome ...how host genotype influences microbial abundance levels ...disrupt host-microbiome associations across ...
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Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses
... the host immunity and gut microbiota in the context of environmen- tal exposures is not well ...immune cell distribution and function, as well as on gut ...immune cell subsets and gut ...
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Gut Microbiota and Mucosal Immunity in the Neonate
... gut microbiota directs the development of the immune system, while the host immune system shapes the establishment of the gut ...tissue immunity and limited ...the microbiota that may cause an ...
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Intestinal Immunity and Gut Microbiota in Atherogenesis
... T cell homeostasis by promoting regulatory T cell func- ...the host, by being able to flourish in the plant polysaccharide-enriched gut envi- ronment and by providing the biological byproducts ...
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Alterations in Gut Microbiota and Immunity by Dietary Fat
... The in vivo effect of Akkermansia on systemic metabolism was demonstrated by oral administration of Akkermansia to mice with diet-induced obesity. Akkermansia administration improves glucose profiles and insulin ...
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Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity
... Spleens were isolated aseptically and single-cell suspensions made in complete media comprising Iscove’s Modified Eagle Medium (IMDM) (Invitrogen) supplemented with 10% heat-inactivated fetal bovine serum (FBS) ...
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Host-microbiota interactions: holobiont theory
... de Goeij JM, van Oevelen D, Vermeij M J A, Osinga R, Middelburg JJ, de Goeij AFPM, Admiraal W, 2013. Surviving in a marine desert: the sponge loop retains resources within coral reefs. Science 342, 108–110. de Goeij JM, ...
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Host-Gut Microbiota Metabolic Interactions
... the microbiota in bile salt metabolism, a study has shown that rodents raised under germ-free conditions or treated with antibiotics have altered hepatic gene expression patterns with changes in genes associated ...
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Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling
... both host factors, such as acetylcholine, and microbial factors, through host innate signaling receptors, including NLRP6 (Birchenough et ...of microbiota (Bogunovic et ...the host immune ...
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Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling
... both host factors, such as acetylcholine, and microbial factors, through host innate signaling receptors, including NLRP6 (Birchenough et ...of microbiota (Bogunovic et ...the host immune ...
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Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment
... the host and microbiota and the maintenance of intestinal health [27] ...Commensal microbiota can prime and modulate host immunity to prevent pathogen ...induce host production ...
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Indole Signaling at the Host Microbiota Pathogen Interface
... there was no change in the concentrations of tryptophan in the ΔtnaA EHEC (Fig. 3C and D). CpxA is an indole sensor. To probe the indole transcriptome, RNA-Seq was performed comparing gene expression from WT or ΔtnaA ...
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The gut microbiota and graft versus host disease
... gut microbiota of HCT recipients, augmenting with strains of bacteria that outcompete pathobionts such as Enterococcus and the Entero- bacteriaceae, while providing critical microbial metabolites such as butyrate, ...
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Pathophysiological role of host microbiota in the development of obesity
... Gut microbiota, Intestinal permeability, Innate immunity, Metabolic inflammation, Endocannabinoid system, Bile acid metabolism, FXR, Short-chain fatty acids, TLRs, FIAF Introduction Today obesity has become ...
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
... gut microbiota during pregnancy but also the offspring ...the host, we detected changes in microbiota during pregnancy suggesting that Nb modulated alterations of microbiota were lasting ...
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Mother's Milk: A Purposeful Contribution to the Development of the infant Microbiota and immunity
... the microbiota are the human milk oligosaccharides (HMOs), the synthesis of which are partially determined by the maternal ...in cell–cell signaling, EVs could therefore may play a further role in ...
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Regulatory functions of sialylated glycans and gut microbiota in mucosal immunity
... intestinal microbiota and mucosal ...gut microbiota, their metabolites and mucosal ...mucosal immunity. Our studies demonstrate for the first time that host-derived glycosylation confers a ...
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The host STING pathway at the interface of cancer and immunity
... Conclusions and future perspectives Activation of the STING pathway is a central innate immune sens- ing mechanism that leads to type I IFN production in the tumor microenvironment. As tumors with a type I IFN signature ...
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