HPAI H5N1
Estimating the sensitivity of passive surveillance for HPAI H5N1 in Bayelsa state, Nigeria.
... Efforts were made by the Federal Government of Nigeria (FGN) in collaboration with several international bodies including the Food and Agricultural Organisation of the United Nations (FAO), the World Bank, the World ...
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Ecology and geography of avian influenza (HPAI H5N1) transmission in the Middle East and northeastern Africa
... of HPAI-H5N1 cases ...of HPAI-H5N1 occurrences, and probably represent the coarse-scale ecological condi- tions under which HPAI-H5N1 transmission ...of H5N1 outbreaks has ...
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Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro inflammatory responses
... (HPAI) H5N1 viruses cause severe infection in chickens at near complete mortality, but corresponding infection in ducks is typically mild or ...two HPAI H5N1 viruses and a low pathogenicity ...
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Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release
... tional regulatory (posttranscriptional or translational) differences in SOCS3 expression between pig and human cells. One such speculation is that the constitutive pig SOCS3 protein is highly stable. The functional ...
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Synergistic Effect of the PDZ and p85β-Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus
... the H5N1 subtype continue to evolve through reassortment and ...of HPAI H5N1 viruses with two char- acteristic mutations in NS1: the avian virus-type PDZ domain-binding motif ESEV (which affects ...
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A New Generation of Modified Live-Attenuated Avian Influenza Viruses Using a Two-Strategy Combination as Potential Vaccine Candidates
... the HPAI challenge at 9 to 12 weeks than at 4 weeks of ...the HPAI H5N1 virus; however, protection was also ob- served in some birds that did not show measurable seroconver- ...
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Virulence and Genetic Compatibility of Polymerase Reassortant Viruses Derived from the Pandemic (H1N1) 2009 Influenza Virus and Circulating Influenza A Viruses
... (HPAI) H5N1 vi- ruses by restricting the induction of the host interferon re- sponse (11, 16, 60, ...among HPAI H5N1 and H7 viruses (21, 28, 40, ...
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Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function
... These studies expand on our initial findings and demonstrate that the A/WSN/33 (WSN) H1N1 virus, like HPAI H5N1 strains, can overcome two cellular blocks to produc- tively replicate in murine macrophages. ...
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One-way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential
... 2012, HPAI H5N1 viruses were experimentally generated that acquired transmissibility in ferrets [49, ...attenuated H5N1 vaccine virus in the ferret URT and increased its immunoge- nicity ...
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Mammalian Innate Resistance to Highly Pathogenic Avian Influenza H5N1 Virus Infection Is Mediated through Reduced Proinflammation and Infectious Virus Release
... to H5N1 virus in- fection between human and pig ...with HPAI H5N1 and USSR H1N1 ...by HPAI H5N1 virus was consistently higher than that by USSR H1N1 vi- rus, a strain responsible for ...
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Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System
... zoonotic H5N1 virus infections are more frequently associated with CNS disease than seasonal or pandemic influenza ...(HPAI) H5N1 virus replicated most efficiently in all cells, which was associated ...
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Modelling the species jump : towards assessing the risk of human infection from novel avian influenzas
... of HPAI H5N1 Clades 1 and 2 are freely available and were downloaded from FAO’s Empres-i website, at ...of H5N1 Clade 1 and 2 isolates, these are listed, along with the characterisation of the virus ...
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The Pattern of Highly Pathogenic Avian Influenza H5N1 Outbreaks in South Asia
... reported HPAI (H5N1) outbreaks in poultry since 2006, and two countries (Bangladesh and Pakistan) reported human cases of H5N1 infection since ...any HPAI outbreaks in poultry or in humans ...
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Retrospective space-time analysis of H5N1 Avian Influenza emergence in Thailand
... (HPAI) H5N1 virus remains a worldwide threat to human and animal health, while the mechanisms explaining its epizootic emergence and re-emergence in poultry are largely ...of HPAI on a daily basis ...
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Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets
... Phylogenetic analyses of four novel avian H5N6 influenza vi- ruses. From 2013 to 2014, four H5N6 viruses were isolated from apparently healthy ducks and geese in live bird markets in China. All eight segments of each ...
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Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses
... with HPAI H5N1 virus leads to the hyperinduction of proinflam- matory cytokines in human primary alveolar epithelial type I-like cells and peripheral blood monocyte-derived macro- phages (PBDMs), compared ...
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The Homologous Tripartite Viral RNA Polymerase of A/Swine/Korea/CT1204/2009(H1N2) Influenza Virus Synergistically Drives Efficient Replication and Promotes Respiratory Droplet Transmission in Ferrets
... Sw/1204 virus in this host (10), indicating the requirement for other viral factors in ferrets. Nonstructural protein 1 (NS1), en- coded by the NS gene, confers efficient replication on human in- fluenza A viruses and is ...
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Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice
... viruses, the polymerase activities of both r-CZ and JY- CZpol vRNPs are much lower but they are much more virulent in mice (Figure 4D) and replicate more efficiently in MDCK cells (Figure 3). Results indicate that influ- ...
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Identification the presence of clade 2.3.2.1C-Avian influenza H5N1, a highly pathogenic virus in Iraq, 2018
... (AIV), H5N1 (Clade 2.3.2.1c), causing highly pathogenic avian influenza (HPAI) in poultry farms, Iraq, ...AIV, HPAI H5N1 from Ivory Coast identified in ...of HPAI H5 outbreaks might be ...
6
Chicken and Duck Myotubes Are Highly Susceptible and Permissive to Influenza Virus Infection
... during H5N1 virus infection would largely reduce the antiviral capacity in chicken ...by HPAI H5N1 viruses in vitro is consistent with the in vivo finding of high levels of HPAI H5N1 ...
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