HPV16 E6
HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo
... of HPV16 E6- E7 in the biological behavior of ESCC ...that HPV16 E6-E7 promoted the migration and invasion ability significantly (Figure ...
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Effects of HPV16 E6 protein on Daxx-induced apoptosis in C33A cells
... Fig. 2 Effects of HPV16 E6 on Daxx expression. A Relative quantification of Daxx RNA via quantitative PCR. Relative quantification of Daxx was evaluated using the double delta Ct ( ΔΔ Ct) method. ★ , p < ...
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Memory T Cells Specific for Novel Human Papillomavirus Type 16 (HPV16) E6 Epitopes in Women Whose HPV16 Infection Has Become Undetectable
... (HPV16) E6 protein has been shown to be associated with successful viral ...within HPV16 E6 protein were previously studied in two women with HPV16 ...be E6 75–83 (KFYSKISEY), ...
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Pre immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer
... received HPV16 E6 (18–26) peptide, while patients on arm B received HPV16 E7 (12–20) peptide pulsed on pre- immature dendritic cells ...the E6 peptide harbored either HPV16 or 18 in ...
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An RNA aptamer targets the PDZ-binding motif of the HPV16 E6 oncoprotein.
... types, HPV16 is the most common causative agent of cervical cancer ...oncoproteins E6 and E7 [6,7]. E6 has been shown to promote degradation of the tumour suppressor p53 by interacting with the E3 ...
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Differential localization of HPV16 E6 splice products with E6 associated protein
... with E6-transfected cells than from E6*I or E6MT-transfected cells (data not ...of E6 protein to oligomerize with E6 or E6*I protein ...of E6*I and E6 protein has been ...
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The PDZ Binding Motif of Human Papillomavirus Type 16 E6 Induces PTPN13 Loss, Which Allows Anchorage-Independent Growth and Synergizes with Ras for Invasive Growth
... Finally, these findings suggest that PTPN13 and its down- stream signaling events play a role in preventing AIG. PTPN13 is a nonreceptor protein tyrosine phosphatase with multiple functional domains (7). The mouse and ...
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Diversifying Selection in Human Papillomavirus Type 16 Lineages Based on Complete Genome Analyses
... variant HPV16 E2 proteins of non-European variants ...among HPV16 E6 and E5 proteins may be a potential force driving the evolutionary selection of the E2 ...instance, HPV16 E2 variants ...
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The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis
... The HPV16 E6 and E7 oncoproteins play important func- tions during the viral life cycle (15, ...HPV E6 and E7 proteins contribute to the viral life cycle by uncoupling the process of epithelial cell ...
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Computational investigation of marine bioactive compounds against E6 oncoprotein of Human Papilloma Virus-HPV16
... Marine sponges have been positioned at the top because of the discovery of bioactive compounds with potential pharmaceutical applications. Specialists in the field of natural products chemistry propose that sponges have ...
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Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.
... HPV16 E6 constructs and mutagenesis. HPV16 E6 was PCR amplified as two fragments, using the oligonucleotide primers 59 gcg gtc gac ATG CAC CAA AAG AGA AC 39, 59 TCT TCC GGA CAC AGT GGC 39, 59 ...
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High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway
... HPV oncogenes cause RAD51 to mislocalize from double-strand DNA breaks. In addition to beginning during the correct part of the cell cycle, repair foci must be properly localized to sites of damage. The sustained ...
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The Ubiquitin-Specific Peptidase USP15 Regulates Human Papillomavirus Type 16 E6 Protein Stability
... from HPV16 E6-expressing stable cells and from control cells were subjected to ...tagged E6 but not from cells transduced with the empty pOZN vector were stained with Coomassie blue and identified by ...
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E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1
... the E6 oncoprotein from the mucosal high-risk (HR) human papillomavirus (HPV) types plays a key role in HPV-mediated cellular transformation in in vitro and in vivo experimental ...HPV E6 oncoproteins have ...
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Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers
... of HPV16 E6 in HPV-positive lung cancer TL-1 cells, the expression of XRCC3 and XRCC5 genes was increased in response to the B[a]P treatment compared with their parental cells (Figure ...16 ...
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Genetic Analysis of High-Risk E6 in Episomal Maintenance of Human Papillomavirus Genomes in Primary Human Keratinocytes
... characterized HPV16 E6 mutations for the study of viral replication, we first replaced HPV31 E6 with HPV16 E6 in the context of the HPV31 genome by using a PCR-based ...The HPV16 ...
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NFX1-123 and Poly(A) Binding Proteins Synergistically Augment Activation of Telomerase in Human Papillomavirus Type 16 E6-Expressing Cells
... HPV16 E6 interacts with the central domain of ...of E6/ E6AP in a yeast two-hybrid screen coexpressing HPV16 E6 and E6AP ...with E6/E6AP by coimmunoprecipitation, and both ...
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NFX1-123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E6 Keratinocytes
... expressing HPV16 E6 and either LXSN, ...of HPV16 E6-expressing HFKs with FLAG-tagged NFX1-123 WT (FN123WT), FLAG-tagged NFX1-123 ⌬ PAM2 (FN123 ⌬ PAM2), or vector control ...in HPV16 ...
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High-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Pluripotent Stem Cells
... HPV E6 and E7 oncogenes ...with HPV16 E6 and E7 and then trans- duced with either the control or a FANCA-expressing retroviral ...if E6 and E7 were ...with E6 and E7, either ...
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NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity
... oncoproteins, E6 and E7, which play central roles in viral replication and oncogenic progression (48, ...of E6 is to interact with a cellular E3 ubiq- uitin ligase, E6-associated protein ...
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