-HSD1
Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH
... Circulating corticosterone levels are determined by an interplay between adrenal production, diurnal rhythm and peripheral 11b-HSD1-mediated regeneration in a range of tissues. Previous studies have shown ...
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TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle
... (Bamias et al. 2013, Golikova et al. 2013, Khosravi et al. 2013, Moelants et al. 2013). We have previously reported that TNFa increases 11b-HSD1 expression and activity in the cells of the mesenchymal lineage, ...
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11β HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy
... Background: Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced ...
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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
... We provide evidence that a consequence of elevated 11b-HSD1 expression and activity in GC excess and aging is the suppression of mitochondrial electron transport chain subunit content, which is rescued in the ...
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Yeast-based assays for screening 11β-HSD1 inhibitors
... Moreover, in recent years the use of yeast-based assays in drug discovery processes has been a driving force for the development of innovative hit-finding approaches based on synthetic biology platforms [37]. Advanced ...
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β-cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction
... exhibited an episodic protection from the severe hyperglycemia caused by a single high dose of STZ associated with higher and sustained β -cell survival, maintained β -cell replica- tive potential, higher plasma and ...
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Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
... Urinary steroid metabolite analysis by GC/MS demon- strated clear sexual dimorphism with increased total and individual glucocorticoid metabolite production rates in men compared with women for subjects with and without ...
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<p>Role of 11β HSD 1, rs12086634, and rs846910 single-nucleotide polymorphisms in metabolic-related skin diseases: a clinical, biochemical, and genetic study</p>
... Our reported positive associations of 11 β -HSD1 rs846910 GA and rs12086634 gene polymorphisms with the reported high BMI and atherogenic lipid profile in investigated AV and ST patients were more impressive, and ...
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Differential expression, function and response to inflammatory stimuli of 11β hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue specific regulation of inflammation
... Autocrine activation of cortisol and the regulation of fibroblast function Autocrine activation of cortisol and the regulation of fibroblast function. Bone marrow, dermal and synovial fibroblasts were treated with ...
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Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells
... high-affinity (Km = 15 nM), inactivating glucocorticoid to its inert metabolite (11-dehydrocorticosterone in rats) unidirectionally [14]. Both of two isoforms of 11β-HSD are expressed in rat Leydig cells [15,16]. ...
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Saturated fatty acids in human visceral adipose tissue are associated with increased 11- β-hydroxysteroid-dehydrogenase type 1 expression
... The difference in HSD11B1 expression between SAT and VAT were calculated for each individual and a subgroup in- cluding the 12 subjects with the largest difference (SAT > VAT) were selected for protein measurements. ...
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The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
... Another set of experiments was performed for histological examinations. After euthanasia, the rats were perfused with 10 % formaldehyde neutral buffer solution (Sigma- Aldrich, St. Louis, MO, USA). Then the maxillary ...
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17beta hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
... In a previous study, we showed that modulating the expression of the steroid-converting enzyme 17b-HSD1 in MCF7 and T47D cells led to a differential cell growth com- pared to the parent cells, cultured in medium ...
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Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue
... containing vanaspati (TFA rich), palm oil (SFA rich) and sunflower oil (PUFA rich) at 10%level on 11b-HSD1 gene expression in rat retroperitoneal adipose tissue. 11b-HSD1 gene expression was significantly ...
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A novel genetically-obese rat model with elevated 11beta-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue
... - HSD1 knock-out mice have decreased TNF- a mRNA in adipose tissue ...- HSD1 in pre-adipocytes has resulted in the decreased expression of IL-6 ...- HSD1 inhibition has been shown to decrease MCP-1 ...
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Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
... Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid reamplification in obesity and ...
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Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
... The functional significance of tissue-specific variations in glu- cocorticoid metabolism was investigated by determining whether increased 11β-HSD1 activity was able to mediate autocrine regulation of the cytokine ...
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11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
... proinflammatory cytokines in mediating muscle wast- ing, it is likely that the loss of their suppression, in the absence of 11β-HSD1, exacerbates inflammatory mus- cle wasting. Although increased leukocyte ...
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An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells
... counteracting the increased 11β-HSD1 activity due to its ir- reversible effects on epigenetic modifications. One potential agent is a selective inhibitor of 11β-HSD1 called PF, which is currently undergoing ...
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Expression of gluconeogenic enzymes and 11β-hydroxysteroid dehydrogenase type 1 in liver of diabetic mice after acute exercise
... diabetic state nor exercise induced changes in the expression of G6Pase. Expression of 11 β -HSD1, the key enzyme that converts inactive CORT to active CORT, and regulating access to the GR, was significantly ...
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