hsp90 inhibitors
Combination of JAK2 and HSP90 inhibitors: an effective therapeutic option in drug-resistant chronic myelogenous leukemia
... JAK2 inhibitors limits its clinical application due to the potential side ...the HSP90 inhibitor AUY922 disrupts the HSP90-HMWNC, we wondered whether an additive inhibition effect could be achieved ...
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Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors
... by a strong growth inhibitory effect (cytostatic). Because cytostatic compounds are not suitable to develop anti- malarial drugs [54], the ability of some of these inhibi- tors to kill the malaria parasite (cytotoxic) ...
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Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors
... old-generation HSP90 inhibitors (ganetespib and geldanamycin, respectively) ...potent HSP90 inhibitor, ...normal HSP90 function is necessary for nuclear import of the receptor [39], ...
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Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors
... such, HSP90 inhibitors have been shown to act as effec- tive anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to ...the ...
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Evaluation of miscellaneous heat shock protein (Hsp90) inhibitors using different methodologies
... small-molecule inhibitors that could be developed as therapeutic agents with improved pharmacological ...of Hsp90 inhibitors with simple chemical structures ...numerous Hsp90 client proteins, ...
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Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling
... or HSP90 inhibitors to reverse resistance to TRAIL-induced apoptosis in human colorectal ...or HSP90 inhibitors in colorectal cancer and suggest useful mechanism-based pharmacodynamic ...
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HSP90 as a novel molecular target in non-small-cell lung cancer
... The HSP90 inhibitors are a diverse group of molecules with a wide range of activity in solid tumors, with ongoing trials presented in Table ...using HSP90 inhibitors is their ability to target ...
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Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
... residue is an important determinant of Hsp90 ATPase activity and drug sensitivity; T22 phosphorylation affects Hsp90 chaperone function and alters its sensitivity to Hsp90 inhibitors.. F[r] ...
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Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension
... a HSP90 inhibitors as therapeutic drugs for PAH treatment, might affect other pathological and physiological processes, such as oxidative stress or neoangiogenesis [14, ...of HSP90 inhibitor as a ...
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Heat-shock protein 90α is involved in maintaining the stability of VP16 and VP16-mediated transactivation of α genes from herpes simplex virus-1
... that Hsp90 inhibition greatly attenuates HSV-1 infection and the expression of HSV-1 α genes (Xiang et ...by Hsp90 inhibition (Additional file 1: Figure S1A and ...whether Hsp90 was involved in ...
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The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
... reticulum HSP90 family member, ...pan-HSP90 inhibitors, was, however, significantly reduced in the absence of ...that HSP90 inhibitors exert their acute cytotoxic activity via ...
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Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells
... The Hsp90- based molecular chaperone complex interacts with its client proteins in an iterative ...way. Hsp90 cycles are driven by ATP- or ADP-bound conformations that are mediated via multiple rounds of ...
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Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis
... other HSP90 inhibitors, depending on the time point of inhibitor appli- cation (14, 15), suggesting a key role for HSP90 in the life cycle of the ...that HSP90 had a higher binding ratio with ...
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Heat Shock Protein 90 Is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus
... of Hsp90 inhibitors as anti-cancer ther- apy (38, 39) has raised considerable interest in this protein as a target for new antifungal ...of Hsp90) and its derivatives 17-(allylamino)-17-demethoxygel- ...
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Elevated Hsp90-beta contributes to differential diagnosis of pleural effusion caused by lung cancer and correlates with malignant biological behavior of lung cancer
... growth, Hsp90 inhibitors are often used as anticancer drugs [8, ...of Hsp90 that have been identified, and Hsp90-alpha and Hsp90-beta are the two major sub- types ...human ...
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Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer
... of HSP90 does not decrease with N-terminal HSP90 ATPase inhibitors as ...of HSP90 inhibitors, it is likely that the biological effect of combination therapy is mediated through impaired ...
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Potential Strategies in Treating Tumours
... Hyaluronidase, Hsp90 Inhibitors, Liposomes, Anti–Angiogenesis agents, Apoptosis Proteins Inhibitors, Histone deacetylases inhibitors, Nanomedicine, Blockade of PD-1/PD-L1 ...
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Ppi of hsp90 and 3d-qsar evaluation study of purine derivatives as anti-carcinogenic substrates of hsp90-overexpressed malignant female breast cancer
... with Hsp90 and its inhibition has been strongly associated with induction of can also be triggered by varied extrinsic and intrinsic signaling ...Most Hsp90 inhibitors bind terminal to inhibit ATPase ...
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Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner
... developed HSP90 inhibitors, such as SNX-2112 and PF- 04928473, do not increase osteoclast formation at therapeuti- cally relevant concentrations (49, 68) because, probably, these agents are more potent than ...
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17 (Allylamino) 17 Demethoxygeldanamycin Combination with Curcumin Selectively Targets Mitogen Kinase Pathway in A Human Neuroblastoma Cell Line
... with Hsp90 inhibitors and cur- cumin in anticancer treatments, we have examined and evaluated the effect of 17AAG in combination with cur- cumin in human neuroblastoma tumor cells, and report that the ...
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