HTLV-1 bZIP factor
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
... type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected CD4 ⴙ T ...The ...
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HTLV 1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling
... Immunodeficiency in ATL patients is pronounced, and results in frequent opportunistic infections by various pathogens [41,42]. As a mechanism of this immunodefi- ciency, HBZ has been shown to inhibit CD4 T-cell ...
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ATF3, an HTLV 1 bZip factor binding protein, promotes proliferation of adult T cell leukemia cells
... changes, ATF3 stabilization of p53 counters cellular stress due to environmental insult and ensures genomic integrity [31,38]. Given that p53 is mutated in only about 30% of ATL cases [43-45], and in fact the expres- ...
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Expression of a protein involved in bone resorption, Dkk1, is activated by HTLV 1 bZIP factor through its activation domain
... defective for Tax-mediated activation of NF-KB signal- ing [68], and K88A is deficient for binding to the KIX domain of p300/CBP [51]. Using qRT-PCR, we found that Tax and M47 reduced the level of Dkk1 mRNA more than ...
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EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV 1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV 1 infected individuals, irrespective of clinical statuses
... type 1 (HTLV-1) was the first human retrovirus identified as a causative agent of human diseases, including adult T-cell leukemia/lymph- oma (ATL) [1–3] and HTLV-1-associated ...
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The HBZ gene, a key player in HTLV 1 pathogenesis
... type 1 (HTLV-1) was discovered in 1980 as the cause of ATL and was the first retrovirus associated with a disease in humans ...in HTLV-1 leukemogenesis remains unclear since expression ...
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A Novel Alternative Splicing Isoform of Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ-SI) Targets Distinct Subnuclear Localization
... type 1 (HTLV-1); however, the mechanism by which HTLV-1 causes adult T-cell leukemia has not been fully eluci- ...of HTLV-1 genome (HBZ) was ...the HTLV-1 ...
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The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
... the HTLV-1 promoter (9, ...the HTLV-1 proviral genome containing the 3⬘ LTR ...a bZIP domain in its C-terminal region, we have named it HBZ (for HTLV-1 bZIP ...
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
... ⌬ bZIP, HBZ (amino acids [aa] 1 to 132) was amplified by PCR and cloned into the EcoRI and HindIII sites of pcDNA-MycHis ...the HTLV-1 molecular clones ACH (30) have also been ...Fig. 1 ...
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The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription
... of HTLV-1 Tax binding proteins, a modified yeast two-hybrid system described earlier was used ...using HTLV-1 Tax as ...acids 1 to 206 (ATFx ⌬ C), lacking the bZIP domain was ...
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bZIP transcription factor interactions regulate DIF responses in Dictyostelium
... a bZIP transcription factor, DimA, which is required for cells to respond to ...DimA-related bZIP transcription factor, ...DIF- 1 is partly due to their ability to form homo- and ...
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Multifaceted functions and roles of HBZ in HTLV 1 pathogenesis
... the bZIP domain [8, 40, 43] and interacting with CBP/p300 via the LXXLL motifs ...an HTLV-1 infectious clone by introducing a premature stop codon (clone termed HBZ-KO), virus production was not ...
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Expression of Glucose Transporter 1 Confers Susceptibility to Human T-Cell Leukemia Virus Envelope-Mediated Fusion
... in HTLV cellular binding and entry. glut-1 is widely expressed and is very highly conserved among mammalian species, which may explain why it has been nigh impossible to identify an HTLV-resistant ...
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The HTLV 1 Tax interactome
... family. HTLV-1 was the first discovered human retrovirus in the early eighties ...[1]. HTLV-2 was described two years later [2] whereas HTLV-3 and -4 subtypes were isolated only ...
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High Human T Cell Leukemia Virus Type 1(HTLV 1) Provirus Load in Patients with HTLV 1 Carriers Complicated with HTLV 1 unrelated disorders
... Results: The present study disclosed extremely high VL with highly dense smears with or without oligoclonal bands in SBH. A high VL of 10% or more was observed in 16 (43.2%) of a total of 33 samples (one of 13 ...
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SUV39H1 interacts with HTLV 1 Tax and abrogates Tax transactivation of HTLV 1 LTR
... in HTLV-1-infected ...the HTLV-1 genome as well as specific cellular genes including inflam- matory cytokines and their receptors and adhesion mole- ...spliced HTLV-1 mRNA ...
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Expansion of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Reservoir in Orally Infected Rats: Inverse Correlation with HTLV-1-Specific Cellular Immune Response
... of HTLV-1 transmission are vertical transmission from mother to child, horizontal transmission from husband to wife, and parenteral transmission via blood transfusion or intravenous injection with ...
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High prevalence of bronchiectasis is linked to HTLV 1 associated inflammatory disease
... The cohort was categorised into HTLV-1 symptomatic patients SPs ATLL, HAM/TSP, Strongyloidiasis and HTLV associated inflammatory disease HAID and HTLV-1 asymptomatic carriers ACs.. The c[r] ...
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Reduction of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Loads in Rats Orally Infected with HTLV-1 by Reimmunization with HTLV-1-Infected Cells
... the HTLV-1-specific cellular and humoral immunities of orally HTLV-1-infected rats were impaired compared to those of intraperitoneally infected rats ...the HTLV-1 proviral load ...
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Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV 1
... of HTLV-1 infection, in conjunction with its inducible expression by IFNγ, similar to other RFs, and its strong inhibitory activity on HTLV-1 as well as HTLV-2 and HIV-1 (Table ...
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