HTLV-1 Tax
Induction of Lactoferrin Gene Expression in Myeloid or Mammary Gland Cells by Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax: Implications for Milk-Borne Transmission of HTLV-1
... that HTLV-1 Tax transactivator played a role, at least to a certain degree, in such paracrine ...(Table 1) or antibodies (lanes 8 to 11) was added to the reaction ...Lane 1 represents ...
9
Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells.
... with HTLV-1, thereby causing parenchymal damage by direct lysis and/or cytokine ...of HTLV-1 mRNA with GFAP-producing cells (a marker for astrocytes) from the spinal cord of a HAM/TSP patient ...
7
XBP-1, a Novel Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Binding Protein, Activates HTLV-1 Basal and Tax-Activated Transcription
... aa 1 to 74, XBP-1U aa 134 to 261, and XBP-1S aa 134 to 378, respectively) were amplified by PCR with a wild-type XBP-1U or XBP-1S vector as the ...vectors. Tax expression vectors containing wild-type ...
11
The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription
... diolabeled HTLV-1 LTR and ATFx proteins were incubated at room temperature for approximately 30 min and the protein/ DNA complexes were separated on a native polyacrylamide gel followed by ...the ...
8
HTLV 1 Tax: centrosome amplification and cancer
... The HTLV-1 Tax protein contributes to the ability of the virus to cause ATL by inactivating p53 [21-24], altering the cell cycle [25,26], and inactivating Rb ...As Tax is able to deregulate ...
6
SUV39H1 interacts with HTLV 1 Tax and abrogates Tax transactivation of HTLV 1 LTR
... with Tax in all cell lines used. These results suggest a possibility that Tax tethers SUV39H1 to the region where Tax is localized ...mutant Tax lacking the NLS directs cytoplasmic ...
14
Wip1 and p53 contribute to HTLV 1 Tax induced tumorigenesis
... to HTLV-1 infection, Tax expression, and the onset of transform- ation of ATLL ...by HTLV-1 foretells a worse prognosis compared to a corresponding infection in a counterpart p53 +/+ ...
12
HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF-κB Activation and HTLV-1 Replication
... three HTLV- 1-transformed cell lines, C8166, MT-2, and MT-4, were treated with different concentrations of 17-DMAG for 24 ...of Tax protein in all three cell ...triggers Tax degra- dation; ...
15
Ubiquitination and sumoylation of the HTLV 2 Tax 2B protein regulate its NF κB activity: a comparative study with the HTLV 1 Tax 1 protein
... type Tax-1 and Tax-2B, though a lower rate of mono- ubiquitination was observed for Tax-2B (Figure ...mutants Tax-1 K1-10R and Tax-2 ...type Tax-1 and ...
13
Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax
... for 1 h at room temperature to inhibit nonspecific binding and was further incubated with either anti-Tax mouse monoclonal antibody (Taxy-8) (55) or rabbit anti-Tax2B polyclonal serum ...
6
Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV 1) tax protein or virus transformed cells
... Phosphorylation of Jak2 in tax transformed cells resulted from high expression of IL-6. Tyrosine phosphorylation of this protein could also be induced in Balb/c3T3 cells using a supernatant from the B line, which ...
9
The HTLV 1 Tax interactome
... family. HTLV-1 was the first discovered human retrovirus in the early eighties ...[1]. HTLV-2 was described two years later [2] whereas HTLV-3 and -4 subtypes were isolated only ...
24
In vivo expression of the HBZ gene of HTLV 1 correlates with proviral load, inflammatory markers and disease severity in HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
... the HTLV-1 proviral load [36] and tax mRNA expression [17] in PBMCs or HTLV-1 infected cell lines as reported previ- ...the HTLV-1 proviral load was calcu- lated using ...
11
Liposomes and nanotechnology in drug development: focus on oncotargets
... and HTLV-1 Tax/HBc chimeric particles are capable of inducing strong cellular immune responses without adjuvants and may be useful as effective carriers for prophylactic or therapeutic uses in ...
9
Host pathogen interactome mapping for HTLV 1 and 2 retroviruses
... for HTLV-1 Tax, Rex, Env and HBZ; and for HTLV-2 Tax, Rex, Env, Pol, Gag, and APH-2 (Figure 2 and Addi- tional file 1: Table S2), providing the first attempt at a large scale ...
20
Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein
... type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy, also known as tropical spastic paraparesis (13, 29, 34, 35, 37, ...
7
Functional impairment of Tax specific but not cytomegalovirus specific CD8+ T lymphocytes in a minor population of asymptomatic human T cell leukemia virus type 1 carriers
... type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1- associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a small percentage of infected ...impaired ...
15
EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV 1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV 1 infected individuals, irrespective of clinical statuses
... the HTLV-1 tax geno- type, PVL, and mRNA expression of tax, HBZ and EOS in HTLV-1 infected individuals from Okinawa, which is located in the subtropical southern-most point and ...
11
Virus induced dysfunction of CD4+CD25+ T cells in patients with HTLV I–associated neuroimmunological disease
... Foxp3 expression analysis by real-time RT-PCR. Total RNA was extracted using RNeasy Mini Kit (QIAGEN) according to the manufacturer’s instruc- tions, and cDNA was synthesized from extracted RNA using TaqMan Gold RT-PCR ...
9
Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator
... Env, HTLV encodes the Tax and Rex trans-regulatory gene products that are essential for efficient viral replication and cellular ...transformation. Tax increases the rate of tran- scription from the ...
7