hUC-MSCs
Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease
... of MSCs on the prognosis of the patients or animals mostly depend on cell vitality and homing ability of the infused cells ...that hUC-MSCs at various passages would result in different therapeutic ...
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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs
... physiological function of heterochromatin organization during this process is not clear. Some studies showed that in the early stage of cellular senescence, heterochro- matin structure underwent dynamic remodeling via a ...
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Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice
... that MSCs can be trapped largely in the capillaries of the lungs by IV transfusion, resulting in death after a few days [15, 29, ...of HUC-MSC transplantation in db/db mice were ...Additionally, ...
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Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p
... whether hUC-MSCs can secrete exo- somes under IL-6 stimulation. hUC-MSCs at passage 3 were cultured with 1 ng/mL IL-6 for 48 ...of hUC-MSC-derived vesicles with a diameter of 50–150 nm ...
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Original Article Characterization of stage-specific embryonic antigen-4 (SSEA-4)-positive very small embryonic-like stem cells isolated from human Wharton’s jelly
... study, hUC-MSCs at P0-P2 represented a heterogeneous cell ...among hUC-MSCs, we cultured hUC-MSCs in medium containing 20 ng/ml EGF, 10 ng/ml bFGF, and 2 mM L-glutamine, which ...
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Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
... that MSCs can be efficiently recruited to tumor sites, modulating tumor growth and ...potency. MSCs and their conditioned media (MSC-CM) could improve the drug resistance of tumor when the compound K (CK) ...
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The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury
... duce hUC-MSCs) gained body weight than vehicle group during the 28 days after TBI ...and hUC-MSCs could mitigate brain edema, and when applied together, edema was further alleviated in the TBI ...
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Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
... Clinical-grade hUC-MSCs were supplied, free of charge, by The Jiangsu Cell Tech Medical Research Institute and The Jiangsu Cell Tech Biotechnology ...of MSCs, including expression (> 95%) of CD73, ...
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In vitro differentiation of human umbilical cord derived mesenchymal stem cells into CD34+ cells via CD34 antibody
... hUC-MSCs were incubated with CD34 antibody (0.01 μmol/l, 0.1 μmol/l or 1 μmol/l, defined as A, B and C group) for 7 d or 14 d. hUC-MSCs without CD34 antibody treatment were used as a control ...
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Effects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells
... identifying MSCs according to the International Society for Cellular Ther- ...of hUC-MSCs, which are consistent with previous stud- ies [13, ...of MSCs were not affected by cryopreservation, ...
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Original Article Human umbilical cord mesenchymal stem cells pretreated with angiotensin-II facilitates angiogenesis by improving the function of endothelial cells
... of hUC-MSC to accelerate the repair of damaged tissues ...protects hUC-MSCs against the apop- totic consequences of subsequent endotoxin insults ...
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Quantification of the CM-Dil-labeled human umbilical cord mesenchymal stem cells migrated to the dual injured uterus in SD rat
... CM-Dil-labeled hUC-MSCs in 500 μl PBS via in- traperitoneal injection as the model with the hUC group (n = ...after hUC-MSCs ...
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Exposure to blue light stimulates the proangiogenic capability of exosomes derived from human umbilical cord mesenchymal stem cells
... from MSCs are enriched in mRNAs or miRNAs and are representative of their cellular origin ...from hUC-MSCs in models of acute kidney injury ...
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Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4
... human MSCs into functional oste- oblasts and increases their in-vivo regenerative potential in immunocompromised mice ...of MSCs is not yet ...human MSCs isolated from BM, adipose tissue (AT) and ...
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Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
... Our study reveals a new approach to reactive senescent cells through exosomes. We reported for the first time that exosomes secreted from young MSCs could effect- ively alleviate the senescent properties of aged ...
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Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta
... differentiated MSCs were then collected, and the endothelial gene expression further comparatively ...EC-differentiated MSCs in comparison with undiffer- entiated cells; however, no statistical significance ...
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Combination therapies enhance immunoregulatory properties of MIAMI cells
... of MSCs may differ in their response to inhibition/ ...of MSCs using existing FDA-approved drugs may represent a rapid way to improve their immunoregulatory properties with- out the high cost and lengthy ...
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Bone Marrow-Derived Mesenchymal Stem Cells Modified with Akt1 Ameliorates Acute Liver GVHD
... manipulating MSCs in vitro has promising potential in improving MSCs' functions to maximize its treatment potential, as shown by several studies ...ing MSCs migration and secretion of paracrine ...
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Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8
... Furthermore, the pro-angiogenic role of GC-MSCs has drawn much interest in the present study, which may be involved in gastric cancer growth and metastasis. Ting and colleagues found that the crosstalk between ...
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Mesenchymal stem cell therapy for osteoarthritis: current perspectives
... tissues. MSCs have a well-documented immunomodula- tory role, managing the inflammatory response primarily through paracrine ...properties, MSCs have been proposed as a potential regenerative cell therapy ...
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